Serotonin Metabolism Parameters in Patients with Chronic Hepatitis and Liver Cirrhosis

Алексеева, А. С.; Белобородова, Э. И.; Rachkovskiy, M I; Naumova, E.; Lambrov, E. G.; Philippova, L. P.

doi:10.1007/s10517-009-0353-1

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…The liver plays an important role in serotonin metabolism, being involved in its formation and inactivation. A Russian study revealed that blood serotonin content decreased in cirrhotic patients diagnosed with pronounced depressive disorders [22], [27]. Disturbance in melatonin homeostasis was also observed in patients with cirrhosis [24], [28].…”

Section: Discussionmentioning

confidence: 99%

Risk of Depressive Disorder following Non-Alcoholic Cirrhosis: A Nationwide Population-Based Study

Perng

Shen

et al. 2014

PLoS ONE

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Background & AimsTo evaluate the risk of depressive disorders among non-alcoholic patients by using the Taiwan National Health Insurance Research Database (NHIRD).MethodsWe conducted a retrospective study of a matched cohort of 52 725 participants (10 545 non-alcoholic cirrhotic patients and 42 180 control patients) who were selected from the NHIRD. Patients were observed for a maximum of 11 years to determine the rates of newly onset depressive disorders, and Cox regression was used to identify the risk factors associated with depressive disorders in cirrhotic patients.ResultsDuring the 11-year follow-up period, 395 (3.75%) non-alcoholic cirrhotic patients and 1 183 (2.80%) control patients were diagnosed with depressive disorders. The incidence risk ratio of depressive disorders between non-alcoholic cirrhotic patients and control patients was 1.76 (95% CI, 1.57–1.98, P<.001). After adjusting for age, sex, and comorbidities, non-alcoholic cirrhotic patients were 1.75 times more likely to develop depressive disorders (95% CI, 1.56–1.96, P<.001) compared with the control patients. The hazard ratios for patients younger than 60 years old (1.31) and female (1.25) indicated that each is an independent risk factor for depressive disorders in non-alcoholic cirrhotic patients.ConclusionsThe likelihood of developing depressive disorders is greater among non-alcoholic cirrhotic patients than among patients without cirrhosis. Symptoms of depression should be sought in patients with cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Risk of Depressive Disorder following Non-Alcoholic Cirrhosis: A Nationwide Population-Based Study

Perng

Shen

et al. 2014

PLoS ONE

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“…При различных патологических изменениях в организме в силу тех или иных причин развивается дисбаланс между интенсивностью свободнорадикальных процессов и функциональной активностью антиоксидантной системы (АОС). Он играет ключевую роль при таких широко распространенных заболеваниях, как гепатит, атеросклероз, ишемическая болезнь сердца, нейродегенеративные и аутоиммунные заболевания, диабетические ангиопатии, катаракта, некоторые формы рака, болезнь Дауна [1,2,5,16]. В то же время у некоторых лекарственных препаратов, используемых для терапии этих заболеваний, были обнаружены прооксидантные свойства [4,13].…”

Section: Introductionunclassified

Evaluating the effectiveness of the antioxidant properties of lipophilic plant products in liposome model test systems in vitro

Im¹,

Есауленко²,

Ri³

et al. 2014

Fiziol Zh

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Оценка эффективности антиоксидантных свойств липофильных продуктов растительного происхождения in vitro методом липосомальной модельной тест-системы В статье представлены результаты об изучении возможности эффективного использования липосомальных модельных тест-систем на основе фосфатидилхолиновых липосом для поиска и оценки антиоксидантных свойств у продуктов растительного происхождения, полученных как экспериментально, так и входящих в состав лекарственных препаратов. В экспериментальных группах, где использовались льняное масло, масла черного и грецкого ореха, фосфоглив, был обнаружен высокий антиоксидантный эффект, что позволяет сделать вывод о необходимости определения дальнейшей стратегии использования антиоксидантов в клинике. Ключевые слова: фосфатидилхолиновые липосомы, антиоксидантная активность, перекисное окисление липидов, прооксидантные свойства.

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“…13 Blood serotonin level was decreased in liver cirrhosis patients with depressive disorder. 14,15 Disarrangement of melatonin homeostasis was presumed to be related to daytime sleepiness and fatigue. 16 Nevertheless, further studies on the possible mechanisms would be needed.…”

mentioning

confidence: 99%

A need for patient-centered care in managing patients with liver cirrhosis

Yoon

2021

Clin Mol Hepatol

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Serotonin Metabolism Parameters in Patients with Chronic Hepatitis and Liver Cirrhosis

Cited by 5 publications

References 5 publications

Risk of Depressive Disorder following Non-Alcoholic Cirrhosis: A Nationwide Population-Based Study

Risk of Depressive Disorder following Non-Alcoholic Cirrhosis: A Nationwide Population-Based Study

Evaluating the effectiveness of the antioxidant properties of lipophilic plant products in liposome model test systems in vitro

A need for patient-centered care in managing patients with liver cirrhosis

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