Seroprevalence of Toxocara spp. in children with atopy

Grama, Daliane Faria; Lescano, Susana Angélica Zevallos; Mota, Kelem Cristina Pereira; Pultz, Brunna dos Anjos; Miranda, Juliana Silva; Segundo, Gesmar Rodrigues Silva; Taketomi, Ernesto Akio; Fernandes, Karla P.; Limongi, Jean Ezequiel; Paula, Fabiana Martins de; Chieffi, Pedro Paulo; Cury, Márcia Cristina

doi:10.1093/trstmh/tru165

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…Surprisingly, dog ownership was not associated with the seropositivity of these children. This finding is in agreement with other studies 49,50 . Our contradictory result could be due to the low sample size especially, in the children who had dogs at home.…”

Section: Discussionsupporting

confidence: 94%

A Survey on the seroprevalence of toxocariasis and related risk factors in Eosinophilic Children of Northwest Iran

Pourgholaminejad¹,

Razipour²,

Heydarian³

et al. 2022

Afr H. Sci.

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Background: Toxocariasis is a serious zoonotic helminthic disease caused by the nematodes; Toxocara species. Aim: A cross-sectional study was conducted to determine the seroprevalence of toxocariasis and related risk factors in eosinophilic children referred to the pediatrics hospital of Qazvin province northwest Iran during 2019-2020. Methods: A total of 200 blood samples were collected from eosinophilic children referred to the Qods Pediatrics Hospital. Demographic data, clinical symptoms, and dogs- and soil-contact history were collected. The presence of anti-Toxocara IgG antibody was evaluated by T. canis IgG ELISA kit. Results: Anti-Toxocara IgG antibodies were detected in 14 (7%) of the total eosinophilic children. The seropositive rate of toxocariasis in hyper-eosinophilic children (>1000/mm3) was 15.1%, while the seropositivity was 4.1% in children with eosinophilia status (500-999/mm3). There was a significant association between the eosinophilia rate and seropositivity (P<0.05). Also, seroprevalence in asymptomatic eosinophilic children was 4.4%, while in children with clinical symptoms it was 17.1%. Accordingly, a statistically significant difference was found between clinical symptoms and Toxocara infection (P<0.05). Conclusion: The prevalence of toxocariasis in eosinophilic children is a serious health problem in the study area. Therefore, serologic evaluation for the diagnosis of Toxocara infection is recommended for eosinophilic children. Keywords: Seroprevalence; Toxocariasis; anti-Toxocara antibody; Eosinophilia children; Qazvin; Iran.

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Section: Discussionsupporting

confidence: 94%

A Survey on the seroprevalence of toxocariasis and related risk factors in Eosinophilic Children of Northwest Iran

Pourgholaminejad¹,

Razipour²,

Heydarian³

et al. 2022

Afr H. Sci.

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“…The patient only showed marked improvement after treatment with thiabendazole. On the other hand, Grama et al 55 and Cadore et al 56 did not find an association between atopy and an increased risk of asthmatic manifestations in children with serological tests positive for anti- Toxocara antibodies. In 2012, Mendonça et al 51 did not find an association between positivity for aeroallergens and Toxocara infections in children living in poor areas of Salvador (Bahia State) and postulated that increased polyclonal IgE levels and the induction of a modified Th2 immune response to Toxocara infection might prevent the development of skin hypersensitivity to aeroallergens.…”

Section: Frequency and Characteristics Of Human Infections Due To Toxocaramentioning

confidence: 91%

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Chieffi¹,

Lescano²,

Fonseca³

et al. 2021

RRTM

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“…These conditions can favor autoinfection by hookworm and ascarid larvae, consequently increasing environmental contamination of yards and streets. The chaining of the dogs in contaminated yards where children play can also lead to exposure of the dogs to infection by protozoa [49][50][51].…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Enteric parasitic infections in children and dogs in resource-poor communities in northeastern Brazil: Identifying priority prevention and control areas

et al. 2020

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The aim of this study was to determine the prevalence and risk factors of the main enteric parasitic infections that affect children and dogs in the municipality of Ilhé us, Bahia, Brazil; and to identify the geopolitical areas that should receive priority interventions to combat them. Between March and November 2016, fecal samples of 143 dogs and 193 children aged 1 month to 5 years were collected in 40 rural and semirural communities using a systematic sampling approach, stratified by district. Samples were collected by legal guardians of the children and / or dog owners. Eggs, larvae, cysts and oocysts of parasites were concentrated by centrifugal-flotation and centrifugal-sedimentation, and acid-resistant staining was used to visualize parasites. One hundred and thirty-two children (68.4%), 111 dogs (77.6%) and 199 (73.7%) dog fecal samples collected from streets were parasitized. Giardiasis, cryptosporidiosis, amoeba infections and hookworm were the most frequent infections in all studied populations, in addition to trichuriasis in dogs and ascaridiasis in children. A predominance of Giardia and hookworms was observed in children and dogs, respectively. The coastal districts of Aritaguá , Olivença and the main district had a higher parasitic diversity and overlapping of important potential zoonotic infections. Age over one year (p<0.001), adjusted OR = 3.65; 95% CI = 1.86-7.16) and income below the minimum monthly salary (p = 0.02, adjusted OR = 2.78, 95% CI = 1.17-6.59) were the main factors associated with intestinal parasitic infections in children and dogs, respectively.

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Seroprevalence of Toxocara spp. in children with atopy

Abstract: Although no statistical association was found between human toxocariasis and atopy, this study revealed a high seroprevalence of Toxocara spp. in children that may indicate environmental contamination with the parasite's eggs in the area where these children live.

Cited by 8 publications

References 27 publications

A Survey on the seroprevalence of toxocariasis and related risk factors in Eosinophilic Children of Northwest Iran

A Survey on the seroprevalence of toxocariasis and related risk factors in Eosinophilic Children of Northwest Iran

Human Toxocariasis: 2010 to 2020 Contributions from Brazilian Researchers

Enteric parasitic infections in children and dogs in resource-poor communities in northeastern Brazil: Identifying priority prevention and control areas

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