Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

Daas, Izaak den; Wemer, J.; Farha, Khalid Abou; Tamminga, Wim J.; Boer, Theo de; Spanjersberg, Rob; Struys, Michel; Absalom, Anthony

doi:10.1007/s00228-012-1443-y

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…These alterations lead to pathological changes in the lipid levels in various tissues of the body. The liver is essential for fat catabolism [ 5 ]. Several studies have shown that the fat composition of the liver in hyperlipidemia patients is significantly different from that of a normal liver [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet

Yin

Matsuoka

et al. 2021

Foods

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Perturbed lipid metabolism leads to ectopic lipid accumulation in tissues, such as the liver, thereby causing nonalcoholic fatty liver disease (NAFLD) and negatively influencing circulating lipid profile-inducing dyslipidemia. Phospholipids (PLs) with special biological activity are used to treat chronic diseases such as cardiovascular and cerebrovascular disease. PLs derived from egg yolk and soya bean have significant antioxidant and lipid-lowering abilities. This study examined the therapeutic effects of them on hyperlipidemia using a high-fructose-fed rat model; lipid metabolism and anti-inflammatory effects were also analyzed. The results showed that both egg yolk and soya bean phospholipids (EPLs and SPLs) reduced liver weight, hepatic TG, and MDA content as well as serum ALT, AST, TBA, and CRP levels (p < 0.05). The PLs also showed hypolipidemic and anti-inflammatory effects. EPLs and SPLs could inhibit the accumulation of hepatic fatty acids C18:1N9C, C18:0, and C22:6NS of rats fed a high-fat-and-sucrose diet. The intake of EPLs could significantly increase acetylcholine content in the blood and brain tissue. Histological examination showed that PLs intake could ameliorate the damage to liver tissue. This study suggested that EPLs and SPLs had a certain capacity of hypolipidemic and liver protection, and the therapeutic benefits of EPLs tended to be more effective than that of soybean phospholipids.

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Section: Introductionmentioning

confidence: 99%

Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet

Yin

Matsuoka

et al. 2021

Foods

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“…After a screening process as previously described, 16 serial CSF and plasma were obtained from eight healthy older volunteers of on average 63.25 years of age (Table 1). Study participants did not have any chronic or acute diseases and were not using any medication.…”

Section: Study Volunteersmentioning

confidence: 99%

“…The methodology of the serial plasma and CSF sampling used in this study was described previously. 16 In brief, after being assessed for eligibility during a 3-week screening period, the subjects came to the Clinical Pharmacology Unit on the evening of day 2. On day 1, an intravenous cannula was inserted.…”

Section: Sampling Of Plasma and Csfmentioning

confidence: 99%

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Dynamics of neutrophil gelatinase‐associated lipocalin plasma and cerebrospinal fluid concentrations in older males

Naudé

Dekens

Eisel

et al. 2017

Eur J Clin Investigation

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“…The procedure was first described by Bruce and Oldfield [4]. There are limited published data on its safety in clinical studies, side effects are expected to be similar to lumbar puncture and considered to be generally well tolerated [5].…”

Section: Introductionmentioning

confidence: 99%

Safety and Tolerability of Lumbar Catheterization and Lumbar Puncture for Cerebrospinal Fluid Analysis in Clinical Neurology Drug Studies

France¹,

Dogterom²,

Ettema³

et al. 2023

Clin Res Trials

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Cerebrospinal fluid is a biofluid contiguous with brain and spinal cord and a plausible tissue for measuring concentrations of central nervous system drugs and biomarkers. Lumbar puncture enables single timepoint sampling while lumbar catheterization enables repeated collection over a period of time. We report here our experience with the procedural safety of both techniques across two phase 1 studies of ESB1609, a brain penetrant sphingosine-1-phosphate receptor agonist, alongside the technical considerations, opportunities, and challenges of implementation. Across both studies, good quality samples were obtained through lumbar puncture and lumbar catheterization. Mild adverse events of post dural puncture headaches were common among participants undergoing lumbar catheterization and resolved with simple analgesics. Surprisingly we found that blood contamination was absent for single lumbar punctures but was detectable throughout the entire lumbar catheter sampling periods, although levels of hemoglobin were very low. We determined that for certain neurological therapeutics, serial cerebrospinal fluid sampling via lumber catheterization in healthy volunteers can provide informative pharmacokinetic and biomarker data but has a relatively high risk of post dural puncture headache compared to lumbar puncture. Acetaminophen co-administered with caffeine might be considered as first line management for post dural puncture headache in appropriate participants.

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Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

Cited by 9 publications

References 12 publications

Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet

Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet

Dynamics of neutrophil gelatinase‐associated lipocalin plasma and cerebrospinal fluid concentrations in older males

Safety and Tolerability of Lumbar Catheterization and Lumbar Puncture for Cerebrospinal Fluid Analysis in Clinical Neurology Drug Studies

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