Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet

Yin, Mingyu; Matsuoka, Ryosuke; Xi, Yong; Wang, Xichang

doi:10.3390/foods10071569

Cited by 13 publications

(28 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results suggest that the increased liver weights and macrovesicular fatty change of the hepatocytes in the HFrD group were caused by the accumulation of triglycerides in the liver. In other words, the daily consumption of excessive fructose for 4 weeks induced a typical NAFLD-like situation, as seen in other reports (12,33,34). In this study, periportal vacuolation in the hepatocytes was observed in the HFrD group after 4-weeks consumption (Table II).…”

Section: Discussionsupporting

confidence: 87%

“…Rats on fructose but not glucosesupplemented diets displayed an abnormal glucose tolerance (11). Furthermore, excessive fructose intake has been widely used as metabolic syndrome-like animal models, including for obesity and diabetes animal models (12)(13)(14)(15). According to these studies, the daily consumption of diets high in fructose can rapidly produce all of the key features of the metabolic syndrome (16).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model

Suzuki

Kondo

Toyoda

et al. 2023

In Vivo

View full text Add to dashboard Cite

Background/Aim: The habitual consumption of excessive fructose is associated with the onset and progression of lifestyle-related diseases, such as nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the physiological changes observed when consuming a diet containing excessive fructose on the viewpoints of hepatotoxicity biological markers using a rat model and explored the biomarker candidates that could detect the effects of excessive fructose intake at an early stage. Materials and Methods: Male rats were fed 63% high fructose diet (HFrD) ad libitum and their blood samples were collected before and at 1, 2, 3, and 4 weeks after allocation. The plasma biochemical parameters, hepatotoxic enzyme activities including alkaline phosphatase (ALP) isozymes were analyzed. Results: HFrD consumption for 4-weeks created NAFLD-like symptoms, including elevated plasma lipid parameters and hepatotoxicity markers, as well as fat accumulation in the liver compared with rats consuming a control diet. Alanine aminotransferase (ALT) and glutamate dehydrogenase (GLDH) were increased from the 3 rd and 2 nd weeks, respectively, but no changes were observed on ALP activity. However, the daily consumption of the HFrD increased the plasma activities of liver-type ALP isozyme, and decreased plasma small intestinaltype ALP isozyme soon after the start of feeding. Conclusion: ALP isozyme analysis in combination with GLDH and ALT activities in the plasma samples could be a useful tool to detect the physiological changes induced by excessive fructose intake at an early stage of the development of NAFLD.

show abstract

Section: Discussionsupporting

confidence: 87%

mentioning

confidence: 99%

Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model

Suzuki

Kondo

Toyoda

et al. 2023

In Vivo

View full text Add to dashboard Cite

show abstract

“…HDL-C is an antiatherosclerotic lipoprotein that is synthesized primarily in the liver and can transport cholesterol from extrahepatic tissue to the liver ( Robertson et al, 2004 ). High serum TC concentrations can stimulate HDL-C transport, leading to transient high cholesterol accumulation in the liver ( Yin et al, 2021 ). Eight studies with 132 animals examined FFA levels after soybean treatment for NAFLD.…”

Section: Resultsmentioning

confidence: 99%

Preclinical and clinical evidence for the treatment of non-alcoholic fatty liver disease with soybean: A systematic review and meta-analysis

Deng

Guo

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD), a prevalent public health issue, involves the accumulation of triglycerides in hepatocytes, which is generally considered to be an early lesion of liver fibrosis and cirrhosis. Thus, the development of treatments for NAFLD is urgently needed. This study explored the preclinical and clinical evidence of soybeans to alleviate NAFLD. Studies indexed in three relevant databases—Web of Science, PubMed, and Embase—between January 2002 and August 2022 were retrieved. A total of 13 preclinical studies and five RCTs that included 212 animals and 260 patients were included in the present analysis. The preclinical analysis showed that liver function indices (AST, SMD = −1.41, p < 0.0001 and ALT, SMD = −1.47, p < 0.0001) were significantly improved in the soybean group compared to the model group, and fatty liver indicators (TG, SMD = −0.78, p < 0.0001; TC, SMD = −1.38, p < 0.0001) and that oxidative stress indices (MDA, SMD = −1.09, p < 0.0001; SOD, SMD = 1.74, p = 0.022) were improved in the soybean group. However, the five RCTs were not entirely consistent with the preclinical results; however, the results confirmed the protective effect on the liver. The results of the clinical RCTs showed that soybean significantly affected liver function, fatty liver, and oxidative stress indicators (ALT, SMD = −0.42, p = 0.006; TG, SMD = −0.31, p = 0.039; MDA, SMD = −0.76, p = 0.007). The current meta-analysis combined preclinical and clinical studies and verified that soybean could protect the liver in NAFLD by regulating lipid metabolism and oxidative stress factors via the Akt/AMPK/PPARα signaling pathway. Soybean might be a promising therapeutic agent for treating non-alcoholic fatty liver disease.Systematic Review Registration: (https://www.crd.york.ac.uk/prospero/#myprospero), identifier (CRD42022335822).

show abstract

“…The various health benefits of eggs have been demonstrated in the existing literature, such as the improvement of blood lipids due to the intake of the phospholipids found in the egg yolk, the improvement of cognitive function due to the choline in the egg yolk [ 4 , 5 ], and increased bone density due to the calcium derived from the eggshells [ 6 ]. In addition, egg whites are characterized by their high dry weight protein content.…”

Section: Introductionmentioning

confidence: 99%

Health Functions of Egg Protein

Matsuoka¹,

Sugano

2022

Foods

Self Cite

View full text Add to dashboard Cite

Egg protein is a remarkably abundant source of protein, with an amino acid score of 100 and the highest net protein utilization rate. However, there have been relatively fewer studies investigating the health benefits of egg protein. In this review, we have summarized the available information regarding the health benefits of egg proteins based on human studies. In particular, studies conducted on the characteristics of egg whites, as they are high in pure protein, have reported their various health functions, such as increases in muscle mass and strength enhancement, lowering of cholesterol, and visceral fat reduction. Moreover, to facilitate and encourage the use of egg white protein in future, we also discuss its health functions. These benefits were determined by developing an egg white hydrolysate and lactic-fermented egg whites, with the latter treatment simultaneously improving the egg flavor. The health benefits of the protein hydrolysates from the egg yolk (bone growth effect) and eggshell membrane (knee join pain-lowering effect) have been limited in animal studies. Therefore, the consumption of egg protein may contribute to the prevention of physical frailty and metabolic syndromes.

show abstract

Comparison of Egg Yolk and Soybean Phospholipids on Hepatic Fatty Acid Profile and Liver Protection in Rats Fed a High-Fructose Diet

Cited by 13 publications

References 31 publications

Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model

Novel Biomarker Establishment for Evaluation of Excessive Fructose Consumption Using a Rat Model

Preclinical and clinical evidence for the treatment of non-alcoholic fatty liver disease with soybean: A systematic review and meta-analysis

Health Functions of Egg Protein

Contact Info

Product

Resources

About