Dynamics of neutrophil gelatinase‐associated lipocalin plasma and cerebrospinal fluid concentrations in older males

Naudé, Petrus J.W.; Dekens, Doortje; Eisel, Ulrich; Daas, Izaak den; Deyn, Peter Paul De

doi:10.1111/eci.12853

Cited by 4 publications

(1 citation statement)

References 32 publications

(55 reference statements)

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“…Serum samples were withdrawn at different hours during the day depending on clinic organization since previous study did not found any circadian influence on systemic LCL2 levels 27 . All patients had an active episode of CSCR at the time of blood sampling defined as the presence of subretinal fluid.…”

Section: Methodsmentioning

confidence: 99%

Lipocalin 2 as a potential systemic biomarker for central serous chorioretinopathy

Matet

Jaworski

Bousquet

et al. 2020

Sci Rep

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No systemic biomarker of Central Serous Chorioretinopathy (CSCR) has been identified. Lipocalin 2 (LCN2 or NGAL), alone or complexed with MMP-9 (NGAL/MMP-9), is increased in several retinal disorders. Serum levels of LCN2 and NGAL/MMP-9 were measured in CSCR patients (n = 147) with chronic (n = 76) or acute/recurrent disease (n = 71) and in age- and sex-matched healthy controls (n = 130). Samples with CRP > 5 mg/L, creatinine > 100 µmol/L, and/or urea > 7.5 mmol/L were excluded. Serum LCN2 was lower in CSCR patients than controls (81.4 ± 48.7 vs 107.3 ± 44.5 ng/ml, p < 0.0001), and lower in acute/recurrent CSCR than controls (p < 0.001) and chronic CSCR (p = 0.006). Serum NGAL/MMP-9 was lower in CSCR patients than controls (47.2 ± 40.7 vs 74.1 ± 42.6, p < 0.0001), and lower in acute/recurrent CSCR than controls (p < 0.001) and chronic CSCR (p = 0.002). A ROC curve showed that for LCN2 serum levels, the 80-ng/ml cutoff value allows to discriminate acute/recurrent CSCR from controls with 80.3% sensitivity and 75.8% specificity, and for NGAL/MMP-9 serum levels, a 38-ng/ml cutoff value allows to discriminate acute/recurrent CSCR from controls with 69.6% sensitivity and 80.3% specificity. In both acute and chronic CSCR, low serum LCN2 and NGAL/MMP-9, provide a biological link between the two CSCR forms, and potential susceptibility to oxidative stress and innate immune dysregulation in CSCR.

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Section: Methodsmentioning

confidence: 99%

Lipocalin 2 as a potential systemic biomarker for central serous chorioretinopathy

Matet

Jaworski

Bousquet

et al. 2020

Sci Rep

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show abstract

Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

Dekens

Eisel

Gouweleeuw

et al. 2021

Ageing Research Reviews

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Sampling issues of cerebrospinal fluid and plasma monoamines: Investigation of the circadian rhythm and rostrocaudal concentration gradient

Janssens

Atmosoerodjo

Vermeiren

et al. 2019

Neurochemistry International

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Dynamics of neutrophil gelatinase‐associated lipocalin plasma and cerebrospinal fluid concentrations in older males

Abstract: This study illustrates the temporal regulation of NGAL in plasma and CSF, which potentially is a useful reference for studies measuring NGAL as biomarker in older individuals.

Cited by 4 publications

References 32 publications

Lipocalin 2 as a potential systemic biomarker for central serous chorioretinopathy

Lipocalin 2 as a potential systemic biomarker for central serous chorioretinopathy

Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases

Sampling issues of cerebrospinal fluid and plasma monoamines: Investigation of the circadian rhythm and rostrocaudal concentration gradient

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