Abstract:Cerebrospinal fluid is a biofluid contiguous with brain and spinal cord and a plausible tissue for measuring concentrations of central nervous system drugs and biomarkers. Lumbar puncture enables single timepoint sampling while lumbar catheterization enables repeated collection over a period of time. We report here our experience with the procedural safety of both techniques across two phase 1 studies of ESB1609, a brain penetrant sphingosine-1-phosphate receptor agonist, alongside the technical considerations… Show more
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