Sequential antimicrobial therapy: pharmacokinetic and pharmacodynamic considerations in sequential therapy

MacGowan, Alasdair; Bowker, Karen E.

doi:10.1016/s0163-4453(98)92721-9

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…Sequential therapy was one of the most important concepts used in compiling the formulary with a preference for drugs available both in parenteral and oral formulations [15]. In sequential therapy, the substance should be the same and can optimise cost by an earlier discharge of the patient from hospital.…”

Section: Methodsmentioning

confidence: 99%

Impact of an antimicrobial formulary and restriction policy in the largest hospital in Italy

Bassetti

Biagio

Rebesco

et al. 2000

International Journal of Antimicrobial Agents

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Section: Methodsmentioning

confidence: 99%

Impact of an antimicrobial formulary and restriction policy in the largest hospital in Italy

Bassetti

Biagio

Rebesco

et al. 2000

International Journal of Antimicrobial Agents

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“…In this section we explore the implications when they are exposed sequentially. Previous studies have explored the effects of sequential exposure of both different antibiotics (Lenhard et al, 2015;MacGowan and Bowker, 1998;Miller et al, 1996) and antibiotics and temperature (Andrade-Linares et al, 2016;Hilker et al, 2016;Manrique et al, 2016;Rangel, 2011). Even transient exposure to a stressor can modify how an organism responds to subsequent stress.…”

Section: Sequential Exposure To Antibiotics and Temperaturementioning

confidence: 99%

Compounding Effects of Climate Warming and Antibiotic Resistance

et al. 2020

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Bacteria have evolved diverse mechanisms to survive environments with antibiotics. Temperature is both a key factor that affects the survival of bacteria in the presence of antibiotics and an environmental trait that is drastically increasing due to climate change. Therefore, it is timely and important to understand links between temperature changes and selection of antibiotic resistance. This review examines these links by synthesizing results from laboratories, hospitals, and environmental studies. First, we describe the transient physiological responses to temperature that alter cellular behavior and lead to antibiotic tolerance and persistence. Second, we focus on the link between thermal stress and the evolution and maintenance of antibiotic resistance mutations. Finally, we explore how local and global changes in temperature are associated with increases in antibiotic resistance and its spread. We suggest that a multidisciplinary, multiscale approach is critical to fully understand how temperature changes are contributing to the antibiotic crisis.

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“…30 In the Netherlands, drug orders are usually given as number of doses per day, rather than in terms of a fixed dosing interval. In most cases, the actual times of administration are chosen by the nurse, rather than by the physician.…”

Section: Commentmentioning

confidence: 99%

“…The increasing tendency to switch from IV to oral administration underscores the requirement of correct dosing intervals of orally administered antibiotics. 30 In the Netherlands, drug orders are usually given as number of doses per day, rather than in terms of a fixed dosing interval. In most cases, the actual times of administration are chosen by the nurse, rather than by the physician.…”

Section: Commentmentioning

confidence: 99%