Improving the Process of Antibiotic Therapy in Daily Practice

Vogtländer, Nils P. J.; Kasteren, M.E.E. van; Natsch, Stephanie; Kullberg, Bart‐Jan; Hekster, Y.A.; Meer, J.W.M. van der

doi:10.1001/archinte.164.11.1206

Cited by 35 publications

(4 citation statements)

References 30 publications

(35 reference statements)

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“…Some of these investigations were conducted by hospital pharmacists themselves [ 39 , 275 ]. Prospective observational studies investigating early switch to oral antibiotics have demonstrated that sustainability can be achieved by checklists, clinical pathways defining criteria for early conversion to oral therapy and its implementation supported by hospital pharmacists [ 258 , 276 – 280 ].…”

Section: Recommendations Of the Guidelinementioning

confidence: 99%

Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases

et al. 2016

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IntroductionIn the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed by the German Society for Infectious Diseases in association with the following societies, associations and institutions: German Society of Hospital Pharmacists, German Society for Hygiene and Microbiology, Paul Ehrlich Society for Chemotherapy, The Austrian Association of Hospital Pharmacists, Austrian Society for Infectious Diseases and Tropical Medicine, Austrian Society for Antimicrobial Chemotherapy, Robert Koch Institute.Materials and methodsA structured literature research was performed in the databases EMBASE, BIOSIS, MEDLINE and The Cochrane Library from January 2006 to November 2010 with an update to April 2012 (MEDLINE and The Cochrane Library). The grading of recommendations in relation to their evidence is according to the AWMF Guidance Manual and Rules for Guideline Development.ConclusionThe guideline provides the grounds for rational use of antibiotics in hospital to counteract antimicrobial resistance and to improve the quality of care of patients with infections by maximising clinical outcomes while minimising toxicity. Requirements for a successful implementation of ABS programmes as well as core and supplemental ABS strategies are outlined. The German version of the guideline was published by the German Association of the Scientific Medical Societies (AWMF) in December 2013.

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Section: Recommendations Of the Guidelinementioning

confidence: 99%

Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases

et al. 2016

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“…There are several well-known ways to decrease the antibiotic resistance such as hand washing, disinfection of hands and hospital tools, prompted laboratory tests, continuous medical education, vaccination, preparation of antimicrobial resistance files, and use of antimicrobial stewardship program (ASP) method [7, 8]. The last one is an optimal use of antibiotics including true antimicrobial drug with an appropriate antibiotic dose (ADe), and duration (ADn) [9–11].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial stewardship program (ASP): an effective implementing technique for the therapy efficiency of meropenem and vancomycin antibiotics in Iranian pediatric patients

Rahbarimanesh

Mojtahedi

Sadeghi

et al. 2019

Ann Clin Microbiol Antimicrob

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BackgroundAntimicrobial stewardship program (ASP) is a distinguished method to improve the prescription and efficacy of antibiotics.AimThe efficacy of ASP and conventional methods was compared to measure the effectiveness of meropenem (MPM) and vancomycin (VMN) antibiotics in pediatric patients.DesignIn an interventional quasi-experimental study, 135 children admitted in Children’s Hospital affiliated to University of Medical Sciences in time periods of 2014–2015 and 2015–2016 were assessed.MethodsThe conventional and ASP methods in 2014–2015 and 2015–2016 were respectively utilized to provide the best antimicrobial therapy of MPM and VMN antibiotics in patient children. The data of mortality rate (MR), antibiotic prescription (AP), antibiotic dose (ADe), antibiotic duration (ADn), length of hospital stay (LOHS), and blood cultures (BCs) were compared across the years using the Chi square, independent t test, and Fisher’s exact test.ResultsThe levels of MR, AP, ADe, ADn, LOHS, and positive BCs using the ASP method in 2015–2016 were significantly lower those of in 2014–2015 using the conventional one (p < 0.05).ConclusionsThe ASP method versus conventional one with a better efficacy can be employed as an antibiotic administration guide for MPM and VMN in the therapy of patients in community-based hospitals.

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“…Considering time, the appropriate dose and manner of administration are the most important aspects of rational drug prescription. [ 11 12 ] Studies have shown that 30%–60% of the prescribing and use of antibiotics has been improper. Many hospitals have turned their supervision on the use of certain antimicrobial agents to change this worrying trend in Iran and all over the world.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and antibiotic resistance pattern of bacteria isolated from urinary tract infections in Northern Iran

et al. 2017

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Background:This study aimed to investigate the bacteria associated with urinary tract infection (UTI) and antibiotic susceptibility pattern of the isolates during 2013–2015 in Northern Iran.Materials and Methods:Overall 3798 patients with clinical symptoms of UTI were subjected as samples, and they were cultured and pure isolated bacteria were identified using biochemical tests and subjected to antibiogram assessment using disc diffusion method.Results:Totally, 568 (14.96%) from 3798 patients had positive UTI. Four hundred and ninety-seven (87.5%) from 568 isolated bacteria were resistant to at least one antibiotic. Escherichia coli, Staphylococcus spp., and Pseudomonas spp. were the most prevalent bacteria. Isolated bacteria indicated the highest antibiotic resistance to methicillin (76.06%) and ampicillin (89.29%) and also revealed the most sensitivity to imipenem (99.1%) and amikacin (91.57%). Statistical analysis of the resistance pattern trend during 3 years indicated the insignificant increase (P > 0.05) in antibiotic resistance of the isolates.Conclusion:The results of this study revealed a great concern for emerging UTI-related multidrug-resistant strains of bacteria causing UTI in Iran.

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Improving the Process of Antibiotic Therapy in Daily Practice

Abstract: Timing of antibiotic therapy and switch therapy may be improved with a combination of interventions. To improve poor adjustment of dosing to renal function, other strategies are needed. In our setting, streamlining was already correct in most cases.

Cited by 35 publications

References 30 publications

Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases

Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases

Antimicrobial stewardship program (ASP): an effective implementing technique for the therapy efficiency of meropenem and vancomycin antibiotics in Iranian pediatric patients

Prevalence and antibiotic resistance pattern of bacteria isolated from urinary tract infections in Northern Iran

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