Sentul Fruit (Sandoricum koetjape) Peel as Anti-Inflammation for Gingivitis after Scaling

Wirata, I Nyoman; Denpasar, Bali Poltekkes Kemenkes; Agung, Anak Agung Gede; Arini, Ni Wayan; Nuratni, Ni Ketut

doi:10.31014/aior.1994.04.04.190

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…The research results on Sentul fruit peel extract from several phytochemical compounds, flavonoid compounds, saponins and tannins are aromatic hydroxyl groups that act as antibacterial. 10 This study aimed to determine the inhibitory ability of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus The results showed that sentul extract was able to inhibit the growth of S. mutans and S. aureus bacteria as seen from the formation of a clear zone. This indicates that the sentul extract has antibacterial ability to the concentration of the extract.…”

Section: Resultsmentioning

confidence: 99%

“…The choice of ethanol solvent and aquades fraction was based on previous research where the sentul ethanol extract of the aqua fraction gave the highest levels of flavonoid compounds, saponins and tannins with flavonoid levels of 11476.16 mg/100g QE, tannins 88.605 mg/g and 6.862 mg/g. 10 Lower concentration certainly contains fewer antibacterial compounds. This is in accordance with Rahmawati et al 11 that the greater the interaction concentration of a given extract, the greater the diameter of the inhibition formed, because the more bioactive components contained in the extract.…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

et al. 2022

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Introduction: Infectious mouth diseases are caused by microorganisms such as Staphylococcus aureus and Streptococcus mutans. Sentul fruit peel extract contains several phytochemical compounds, flavonoid compounds, saponins and tannins are aromatic hydroxyl groups that act as antibacterial so that they can be used as a treatment for infections of the mouth. This study aimed to determine the inhibitory ability of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus Aureus bacteria which can cause oral infections. Method: Sentul fruit peel simplicia was extracted by maceration method with ethanol for 24 hours. The maceration method was chosen in this study because it is a method that is easy to do and uses simple tools, which is enough to soak the sample in a solvent. A filtering process followed this and the filtrate was then evaporated with a vacuum rotary evaporator at a temperature of 45oC, so that a thick extract was produced. The maceration process was repeated 2 times. After the extraction process, then proceed with liquid-liquid fractionation using distilled water. The thick extract was put into a separating funnel and distilled water was added. Then it was shaken and the aquadest fraction was taken, followed by evaporation with a vacuum rotary evaporator at 45oC, so that the aqua fraction of the ethanol extract was produced. Result: The results showed that the Sentul fruit peel extract was able to inhibit the growth of S. mutans and S. aureus bacteria as seen from the formation of a clear zone. Based on the ANOVA test, the extract concentration treatment had a significant effect (p<0.005) on the diameter of the clear zone on S. mutans and S. aureus bacteria. Positive control (streptomycin) showed significant differences in Duncan's test, because it produced the greatest antibacterial activity against test bacteria compared to negative control and various extract concentrations. The diameter of the clear zone in the positive control against S. mutans and S. aureus bacteria were 17.63±0.28 mm and 17.62±1.04 mm, respectively. Sentul peel ethanol extract of aqua fraction at a concentration of 100% gave the highest inhibition zone compared to concentrations of 75%, 50%, and 25%, although it was still smaller than the diameter of the clear zone in the positive control. In bacteria S. mutans, the ethanol extract of Sentul peel aqua fraction at a concentration of 100% gave a clear zone diameter of 14.31±1.06 mm and in S. aureus bacteria it gave a clear zone diameter of 15.34±1.81 mm. Conclusion: Sentul fruit peel extract (Sandoricum koetjape) has the ability to inhibit Streptococcus mutans bacteria and Staphylococcus Aureus bacteria.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

et al. 2022

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“…Sandoricum koetjape leaf has xanthine oxidase inhibitory and antioxidant properties [11]. After scaling, an ethanol extract of Sandoricum koetjape fruit peel has anti-gingival inflammation properties [12].…”

Section: Introductionmentioning

confidence: 99%

“…MCF-7 cells from humans with breast cancer are cytotoxic to gallic acid and caffeic acid, inducing apoptosis [15]. Koetjapic acid, a phenolic acid found in the bark of Sandoricum koetjape, has anticarcinogenic properties [12]. Katonic acid, another phenolic acid derived from Sandoricum koetjape, was found to be cytotoxic to ten cancer cell lines [16].…”

Section: Introductionmentioning

confidence: 99%

Seven types of phenolic acid and inhibitory activity for protein tyrosine phosphatase 1B (PTP1B) from the stem of Sandoricum koetjape

Saadah,

Tulandi,

Rohman

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Sandoricum koetjapehas been traditionally used in Indonesian medicine for generations. The stem was used as a remedy for helminthiasis, sneezing, stomachache, indigestion, abdominal pain, leucorrhea, colic, and fever in Indonesia. The purpose of this study was to identify the phenolic acids found in the stem ofS. koetjapeand to test their ability to inhibit the protein tyrosine phosphatase 1B (PTP1B). P-coumaric acid, caffeic acid, ferulic acid, chlorogenic acid, syringic acid, 4-hydroxybenzoic acid, and gallic acid were identified as phenolic acids found in theS. koetjapestem. The interaction of phenolic acids with the PTP1B was predicted using molecular docking. PTP1B has been linked to diabetes, obesity, tumors, and Alzheimer’s. The autodock 4.2 program, which is integrated with the pyrx v.09.8 virtual screening tool, was used to conduct the docking studies. Interacting between p-coumaric acid with PTP1-B on amino acids Glu115, Lys116, Lys120, Cys215, Ala217, Gly218, Ile219, Gly220, and Arg221. P-coumaric acid fulfills Lipinski’s rule and therefore can be taken orally. P-coumaric acid is expected to have a high oral bioavailability in humans, great absorption in the intestine, and an equivalent distribution in blood plasma and intestine. P-coumaric acid’s acute toxicity is also expected to be low. P-coumaric acid is also non-toxic to the liver, immune system, mutagenic, and cytotoxic.Sandoricum koetjapephenolic acids, particularly p-coumaric acid, appeared to be an effective PTP1-B inhibitor based on docking results.

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“…The leaf of S. koetjape has xanthine oxidase inhibitory activity and antioxidant activity (Hamzah et al 2020). S. koetjape fruit peel ethanol extract has anti-inflammation properties for gingivitis after scaling (Wirata et al 2021). In vitro studies showed the pharmacological potential of S. koetjape extract, including antioxidant, antibacterial, anticancer, antitumor, and insecticide activities (Wijaya 2022).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape

SAADAH¹,

TULANDI²,

ROHMAN³

2022

Biodiversitas

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Abstract. Saadah S, Tulandi SM, Rohman RA. 2022. Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape. Biodiversitas 23: 6199-6207. Sandoricum koetjape has been used in traditional Indonesian medicine for centuries. In Indonesia, the stem and leaves were used to treat helminthiasis, cough, stomachache, diarrhea, bloating, leucorrhoea, colic, and fever. To ascertain the phytochemical constituents of each plant part, and provide a sufficient basis for clinical application, so Gas Chromatography-Mass Spectrometry (GC/MS) analysis of stems and leaves was established. Phytochemical screening showed that stems and leaves contained alkaloids, flavonoids, quinone, triterpenoids, and tannin. Total phenolics in the leaves are higher than in the stem. Saponin and steroids were not detected. The GC/MS analysis indicated that the leaf extract contained more identified compounds (30) than the stem extract (28). Both S. koetjape samples contained 1H-Cycloprop[e]azulen-7-ol. The major compounds of the stem extract of S. koetjape are Fonenol (12.89%), 1H-Cyclopenta[1,3]cyclopropa[1,2]benzene (12.54%), and 1H-Cycloprop[e]azulen-7-ol (11.70%), while the major compounds in leaf methanol extract were 14,15-didehydro-Cyclodecacyclotetradecene (23.71%), 1H-Cycloprop[e]azulen-7-ol (17.04%), and Solanesol (8.34%). The two main components of the variable can account for 50.92% of the total variance, according to Principal Component Analysis (PCA) (PC1 is 21.19% and PC2 is 29.74%). These results indicate that the two components effectively categorize samples with distinct characteristics. The groups were divided based on the type of sample used, namely stem and leaf samples. According to the loading plot, 1H Cyclopenta[1,3]cyclopropa[1,2]benzene and Fonenol are two components that are very effective in categorizing samples based on their type. Both metabolites are higher in the stem than in the leaf. However, the metabolites activities of S. koetjape stem and leaves extracts could be revealed by further studies using in silico and in vitro approaches.

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Sentul Fruit (Sandoricum koetjape) Peel as Anti-Inflammation for Gingivitis after Scaling

Cited by 4 publications

References 17 publications

Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

Antibacterial activity of Sentul fruit peel extract (Sandoricum koetjape) against Streptococcus mutans and Staphylococcus aureus

Seven types of phenolic acid and inhibitory activity for protein tyrosine phosphatase 1B (PTP1B) from the stem of Sandoricum koetjape

Phytochemical and gas chromatography-mass spectrometry profiling of two plant parts of Sandoricum koetjape

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