Sensitivity profile of multidrug resistant Acinetobacter Spp. isolated at ICUs of tertiary care hospital

Shrivastava, Gunjan; Bhatambare, Ganesh S; Bajpai, Trupti; Patel, Kamlesh

doi:10.4103/2347-9019.130731

Cited by 8 publications

(8 citation statements)

References 1 publication

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“…Due to the widespread dissemination among nosocomial pathogens via plasmids and integrons, ESBL genes can cause further expansion of drug resistance, including MDR isolates (14,24). Various studies have reported frequencies of ESBL genes in A. baumannii ranging from 25% to 93.45% (25)(26)(27)(28). In the present study, among the 80 examined isolates of A. baumannii, 53.8% were ESBL producers, which is consistent with the results of previous studies.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of Extended-Spectrum β-Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran

Azizi

Mortazavi

Etemadimajed

et al. 2017

Jundishapur J Microbiol

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Section: Discussionsupporting

confidence: 91%

Prevalence of Extended-Spectrum β-Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran

Azizi

Mortazavi

Etemadimajed

et al. 2017

Jundishapur J Microbiol

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“…But the maximum numbers w from Tracheal aspirate and minimum number was isolated from urine. This is in contrast to the study by Shrivastava, et al in which the maximum isolation of Acinetobacter species was from urine than the respiratory secretions [15]. samples which revealed Acinetobacter were urine, 48 (57.8%) were blood and 12 ( ).…”

Section: : Antibiotic Sensitive and Resistance Pattern Of Acinetobaccontrasting

confidence: 74%

“…were isolated from all the e tracheal aspirate, blood, pus, urine, CSF But the maximum numbers were isolated from Tracheal aspirate and minimum number was isolated from urine. This is in contrast to the study by et al in which the maximum isolation of Acinetobacter species was from urine than the respiratory secretions [15]. In their study Out of 83…”

Section: : Antibiotic Sensitive and Resistance Pattern Of Acinetobaccontrasting

confidence: 59%

Prevalence and resistance pattern of Acinetobacter species in PICU and NICU in a tertiary care Paediatric hospital in Bangalore

Manasa

2017

Trop J Pathol Microbiol

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Objectives: Acinetobacter species are one of the most frequent nosocomial pathogen and can cause a wide range of infections, including bacteremia, pneumonia, urinary tract infection, peritonitis, etc. This organism is becoming resistant to a large group of antibiotics, especially β-lactam antibiotics and also carbapenems. Aim: To determine the prevalence of Acinetobacter species in the patients of NICU and PICU of a tertiary care paediatric hospital and also to study their resistance pattern. Materials and Methods: This is a retrospective study done over a period of 12 months from January 2016 to December 2016. The Acinetobacter species isolates by all the clinical samples from NICU and PICU were identified by colony characteristics and biochemical reactions. The resistance patterns of these isolates were identified using various antibiotics by Kirby-Bauer disc diffusion test as per CLSI guidelines. Their antibiogram data and a clinical correlation was made to assess their pathogenic status and mode of acquisition. Results: Acinetobacter species was isolated in 280(30.7%) samples out of 911(17.75%) culture positive isolates from a total of 5131cultures from NICU and PICU. Maximum isolates were from Tracheal aspirate 93 (57%) followed by pus (52.71%) and blood 88(19.4%). The organism showed high rate of resistance to cefazolin (96.5%) ampicillin (91.8%), amoxyclav (85.2%) ceftriaxone (88.5%), piperacillin (82.9%), ceftazidime (77.5%), amikacin (75.2%) and ciprofloxacin (86.9%). The organism showed moderate resistance to Imipenem(68%) , meropenum (65%) and colistin (60%). Conclusion: In this study, Acinetobacter species was resistant to many drugs including imepenum and meropenum and there was a significant relationship between patients on mechanical ventilation, length of hospital stay and drug resistance.

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“…The susceptibility profile ranged against ceftazidime (0-79%; IQR: 14-31), piperacillin-tazobactam (10-66%; IQR: 13-44) imipenem (20-71%; IQR: 30-60), meropenem (10-73%; IQR: 24-49), amikacin (15-61%; IQR: 17-55), tobramycin (38-84%; IQR: 41-63), netilmicin (35-77%; IQR: 36-65) and colistin (78-100%; IQR: 86-99)949596979899100 (ICMR-AMRSN, unpublished data).…”

Section: Typhoidal and Non-typhoidal Salmonellamentioning

confidence: 99%

“…Among β-lactam resistance, bla PER-like (41-76%)101 gene is most predominantly reported followed by bla TEM like(8-87%)101. Carbapenem resistance in A. baumannii is predominantly mediated by class D carbapenemase bla OXA-23-like (42-99%) followed by Class B metallo-β-lactamase bla NDM-like (14-60%), bla VIM-like (1-59%) and bla IMP-like (36-55%)9496100101102.…”

Section: Typhoidal and Non-typhoidal Salmonellamentioning

confidence: 99%

Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India

Veeraraghavan¹,

Walia²

2019

Indian J Med Res

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Antimicrobial resistance is a major concern globally. Infections due to drug-resistant pathogens are becoming difficult and a challenge to treat. As treatment choices are limited due to the high-drug resistance rates, there is an increase in the health care cost, duration of hospital stay, morbidity and mortality rates. Understanding the true burden of antimicrobial resistance for a geographical location is important to guide effective empirical therapy. To have a national data, it is imperative to have a systemic data capturing across the country through surveillance studies. Very few surveillance studies have been conducted in India to generate national data on antimicrobial resistance. This review aims to report the cumulative antibiogram and the resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India.

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Sensitivity profile of multidrug resistant Acinetobacter Spp. isolated at ICUs of tertiary care hospital

Cited by 8 publications

References 1 publication

Prevalence of Extended-Spectrum β-Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran

Prevalence of Extended-Spectrum β-Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran

Prevalence and resistance pattern of Acinetobacter species in PICU and NICU in a tertiary care Paediatric hospital in Bangalore

Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India

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