Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India

Abstract

Antimicrobial resistance is a major concern globally. Infections due to drug-resistant pathogens are becoming difficult and a challenge to treat. As treatment choices are limited due to the high-drug resistance rates, there is an increase in the health care cost, duration of hospital stay, morbidity and mortality rates. Understanding the true burden of antimicrobial resistance for a geographical location is important to guide effective empirical therapy. To have a national data, it is imperative to have a systemic data capturing across the country through surveillance studies. Very few surveillance studies have been conducted in India to generate national data on antimicrobial resistance. This review aims to report the cumulative antibiogram and the resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India.

Surveillance of potential pathogens and antibiotic resistance in wastewater and surface water from Boston, USA and Vellore, India using long-read metagenomic sequencing

“…Of the primary alignments to OXA genes on plasmids in the Vellore hospital effluent (OXA-1, OXA-164, OXA-181, OXA-392, OXA-58), one (OXA-181) was an OXA48-like allele. E. coli isolates in hospitals in India also contained resistance genes to other classes of antibiotics that we identified using metagenomic sequencing on plasmids in the Vellore hospital effluent, including tetA and tetB, dfrA17, sul1, and catB3 61 .…”

Genomic Portrait of Community-Associated Methicillin-Resistant Staphylococcus Aureus ST772-SCCmec V Lineage From India

“…In the Asia-paci c region, ve distinct sequence types (STs); ST59, ST30, ST72, ST8, and ST772 are the predominant and often spread to hospitals [5]. In India, MRSA accounts for 37% of S. aureus infections [6,7]. However, very few studies have reported the molecular epidemiology of S. aureus.…”

Bir Üniversite Hastanesinde Kan Kültürlerinden İzole Edilen Bakterilerin Kümülatif Antibiyogram Sonuçları

“…Bizim çalışmamızdaki MRSA oranının (%38,3) Türkiye geneli ve Avrupa ülkeleri ortalamasından yüksek olduğu görülmektedir. Buna karşılık, Uzakdoğu ülkelerinden Hindistan' da yapılan direnç sürveyans çalışmasında MRSA izolatlarının oranı ülkemizden ve Avrupa ülkelerinden daha yüksek (% 40) olarak bulunmuş, ayrıca S. aureus izolatları arasında %5,8 VISA ve %6,9 hVISA izolatı olduğu bildirilmiştir(13).Enterococcus spp:…”