Semi-IPNs and IPN-based hydrogels

Zoratto, Nicole; Matricardi, Pietro

doi:10.1016/b978-0-08-102179-8.00004-1

Cited by 49 publications

(35 citation statements)

References 99 publications

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“…Some other techniques are also available for identifying the morphology of the IPNs. Some of the generally mentioned techniques are confocal laser microscopy, laser scanning confocal microscopy and atomic force microscopy [53].…”

Section: Characterization Based On Morphology Of the Ipnmentioning

confidence: 99%

“…Polysaccharide supports stable helical confirmation in aqueous solution that is triple-stranded bonded together by hydrogen bonds. It exhibits resistance to hydrolysis, and its rheological behavior makes scleroglucan broadly explored in cosmetics, in food industries and also in pharmaceutical field [53]. Hydrolysis of innovative SIPN was carried out by cross-linking chromium triacetate with solution of scleroglucan and slightly hydrolyzed polyacrylamide.…”

Section: Scleroglucanmentioning

confidence: 99%

“…Due to the biocompatible nature, dextran has a number of applications such as plasma expander and antithrombotic agent (reduced blood viscosity). Dextran also owns various functional groups of pendant hydroxyls showing usefulness to chemical modification which results in synthesizing derivatives of dextran having required features [53]. LBG has properties to strengthen cyst-chitosan and oxidized dextran-based SIPN cryogel for hemostatic application improving the mechanical strength and fast fluid responsiveness supporting blood clotting water-soluble polysaccharide.…”

Section: Dextranmentioning

confidence: 99%

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Interpenetrating polymer network as a pioneer drug delivery system: a review

et al. 2019

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Interpenetrating polymer network (IPN) is an enterprising drug delivery system, comprising of two polymers with several advantages like stability, biocompatibility, high swelling capacity and biodegradability which plays an important function in targeted and controlled drug delivery. IPN acquired appreciable focus in the pharmaceutical sector mostly for the last few decades because of their utility in biomedical applications like tissue engineering and drug delivery at the target site at desired rate. For the past few years, different types of polymers obtained from natural or artificial sources have been used to prepare the IPN, resulting in improved properties; thus, IPN is considered in the category of the novel technologies demonstrating the superior performances as compared to the conventional technique. IPN development leads to the formation of dosage form with reduced side effects and prolonged drug action. The current topic includes IPN, types of IPN, mode of preparation, applications, delivery systems and list of polymers employed in the synthesis of IPN.

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Section: Characterization Based On Morphology Of the Ipnmentioning

confidence: 99%

Section: Scleroglucanmentioning

confidence: 99%

Section: Dextranmentioning

confidence: 99%

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Interpenetrating polymer network as a pioneer drug delivery system: a review

et al. 2019

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“…In this regard, semi-IPNs and IPNs can lead to reinforced interwoven polymer networks. An IPN can be defined as a polymeric matrix comprising two crosslinked networks interlaced on a molecular scale, whilst a semi-IPN is a matrix comprising only one crosslinked network, in which the linear or blanched polymer penetrates the network on a molecular scale, i.e., the linear or branched macromolecules are dispersed into the polymer network [ 27 ]. Mechanically enhanced DNs, characterized by good mechanical properties, are formed by a first densely cross-linked ionic hydrogel and a neutral loosely cross-linked network [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…These hybrid structures combine the advantageous properties of each polymeric component leading to a new material with properties that may be different from those of the pure components [ 27 , 30 ]. Depending on the nature of the constituent polymers, the combination of synthetic and natural polymers, with hydrophobic and hydrophilic properties, can result in a broader range of properties and applications [ 25 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Semi-Interpenetrated Polymer Networks of Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate)/Poly (Vinyl Alcohol) with Incorporated Conductive Polypyrrole Nanoparticles

et al. 2020

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This paper reports the preparation and characterization of semi-interpenetrating polymer networks (semi-IPN) of poly(3-hydroxybutirate-co-3-hydroxyvalerate), PHBV, and poly (vinyl alcohol), PVA, with conductive polypirrole (PPy) nanoparticles. Stable hybrid semi-IPN (PHBV/PVA 30/70 ratio) hydrogels were produced by solvent casting, dissolving each polymer in chloroform and 1-methyl-2-pyrrolidone respectively, and subsequent glutaraldehyde crosslinking of the PVA chains. The microstructure and physical properties of this novel polymeric system were analysed, including thermal behaviour and degradation, water sorption, wettability and electrical conductivity. The conductivity of these advanced networks rose significantly at higher PPy nanoparticles content. Fourier transform infrared spectroscopy (FTIR) and calorimetry characterization indicated good miscibility and compatibility between all the constituents, with no phase separation and strong interactions between phases. A single glass transition was observed between those of pure PHBV and PVA, although PVA was dominant in its contribution to the glass transition process. Incorporating PPy nanoparticles significantly reduced the hydrogel swelling, even at low concentrations, indicating molecular interactions between the PPy nanoparticles and the hydrogel matrix. The PHBV/PVA semi-IPN showed higher thermal stability than the neat polymers and PHBV/PVA blend, which also remained in the tertiary systems.

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Carbohydrate‐Based Materials in Tissue Engineering Applications

Rostami¹

2021

Nanoengineering of Biomaterials

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Semi-IPNs and IPN-based hydrogels

Cited by 49 publications

References 99 publications

Interpenetrating polymer network as a pioneer drug delivery system: a review

Interpenetrating polymer network as a pioneer drug delivery system: a review

Novel Semi-Interpenetrated Polymer Networks of Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate)/Poly (Vinyl Alcohol) with Incorporated Conductive Polypyrrole Nanoparticles

Carbohydrate‐Based Materials in Tissue Engineering Applications

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