Novel Semi-Interpenetrated Polymer Networks of Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate)/Poly (Vinyl Alcohol) with Incorporated Conductive Polypyrrole Nanoparticles

Abstract

This paper reports the preparation and characterization of semi-interpenetrating polymer networks (semi-IPN) of poly(3-hydroxybutirate-co-3-hydroxyvalerate), PHBV, and poly (vinyl alcohol), PVA, with conductive polypirrole (PPy) nanoparticles. Stable hybrid semi-IPN (PHBV/PVA 30/70 ratio) hydrogels were produced by solvent casting, dissolving each polymer in chloroform and 1-methyl-2-pyrrolidone respectively, and subsequent glutaraldehyde crosslinking of the PVA chains. The microstructure and physical properties of this novel polymeric system were analysed, including thermal behaviour and degradation, water sorption, wettability and electrical conductivity. The conductivity of these advanced networks rose significantly at higher PPy nanoparticles content. Fourier transform infrared spectroscopy (FTIR) and calorimetry characterization indicated good miscibility and compatibility between all the constituents, with no phase separation and strong interactions between phases. A single glass transition was observed between those of pure PHBV and PVA, although PVA was dominant in its contribution to the glass transition process. Incorporating PPy nanoparticles significantly reduced the hydrogel swelling, even at low concentrations, indicating molecular interactions between the PPy nanoparticles and the hydrogel matrix. The PHBV/PVA semi-IPN showed higher thermal stability than the neat polymers and PHBV/PVA blend, which also remained in the tertiary systems.

In Situ Hydroxyapatite Synthesis Enhances Biocompatibility of PVA/HA Hydrogels

“…Unfortunately, it does not support cell attachment and due to insufficient protein absorption, biological bond formation is hindered. To avoid these shortcomings, PVA could be modified with other components [12,13].…”

Prosthetic meshes for hernia repair: State of art, classification, biomaterials, antimicrobial approaches, and fabrication methods

“…253 Polyvinyl alcohol (PVA) is another biomaterial hydrogel with excellent biocompatibility and water sorption properties. 272 Meshes with a broad range of porosities with pores of different shapes and sizes using different sized threads can be produced with PVA and PP loaded ciprofloxacin hydrochloride to minimize post hernioplasty infections by FDM 3D printing (see Figure 5). 93 All of the 3D printed antimicrobial meshes showed outstanding mechanical performance in vivo biocompatibility, adhesion capacity, mild-to-moderate appearance of adhesions to visceral tissue, and did not exhibit signs of implant rejection.…”

Prosthetic Meshes for Hernia Repair: State of Art, Classification, Antimicrobial Approaches, and Fabrication Methods

“…A polymer-based hyaluronic acid-poly(N-isopropylacrylamide)(HApN) hydrogel that can be used as drugloaded coating of gentamicin and rifampicin applicable to different meshes to provide strong antimicrobial activity against S. aureus, MRSA, S. epidermidis and less against E. coliin vitro [243]. Polyvinyl alcohol (PVA) is another biomaterial hydrogel with excellent biocompatibility and water sorption properties [262].…”