Self-assembled nanoparticles based on hydrophobically modified chitosan as carriers for doxorubicin

Zhang, Jing; Chen, Xi Guang; Li, Yan Yan; Liu, Chengsheng

doi:10.1016/j.nano.2007.08.002

Cited by 150 publications

(72 citation statements)

References 25 publications

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“…[98] Glycol-chitosan nanoparticles have shown the best encapsulation efficiency of 97%, [79] which might be a better option as far as chitosan DDSs are concerned, compared with oleoyl-chitosan nanoparticles which only managed an EE of 52.6%. The process of doxorubicin encapsulation did not affect doxorubicin's cytotoxic properties; instead studies have shown that doxorubicin encapsulation into chitosan had improved doxorubicin's cytotoxicity both in vitro [81,91,97,98] and in vitro. [78,79,83,85,86] Conversely some groups found that doxorubicin-chitosan technology proved to be only as efficacious as doxorubicin solution alone.…”

Section: Discussionmentioning

confidence: 90%

Review: doxorubicin delivery systems based on chitosan for cancer therapy

Tan¹,

Choong²,

Dass³

2009

j pharm pharmacol

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Objectives This review sheds insight into an increasingly popular polymer that has been widely explored as a potential drug delivery system. The abundant, biodegradable and biocompatible polysaccharide chitosan, with many other favourable properties, has been favoured as a drug delivery system for the purposes of encapsulating and delivery of doxorubicin with reduced side-effects. Key findings Doxorubicin is frequently used as a frontline chemotherapeutic agent against a variety of cancers. It has largely been able to demonstrate anti-tumour effects, though there are major shortfalls of doxorubicin, which include serious side-effects such as cardiomyopathy and myelosuppression, and also an ever-present danger of extravasation during drug administration. In view of this, drug delivery systems are currently being explored as alternative methods of drug delivery in a bid to more effectively direct doxorubicin to the specific lesion site and reduce its systemic side-effects. Liposomes and dendrimers have been tested as potential carriers for doxorubicin; however they are not the focus of this review. Summary Recent advancements in doxorubicin and chitosan technology have shown some preliminary though promising results for cancer therapy.

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Section: Discussionmentioning

confidence: 90%

Review: doxorubicin delivery systems based on chitosan for cancer therapy

Tan¹,

Choong²,

Dass³

2009

j pharm pharmacol

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“…Zhang et al [70] prepared doxorubicin-loaded self-assembled oleoyl-chitosan (OCH) nanoparticles. The in vitro toxicity profile of OCH nanoparticles was evaluated by hemolysis test and MTT assay.…”

Section: Systemic Versus Localized Drug Delivery Systemsmentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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“…Meanwhile, the nanoparticles exhibited a sustained release after a burst release at phosphate-buffered saline (pH 7.4). 73 As the anomalies of temperature are common and important signs of various diseases, especially for bacterial infection, temperatureresponsive polymers have become increasingly attractive as carriers for the controlled drug-delivery systems. In addition, the controlled release of drugs can also be achieved by the exertion of the local thermal field in vitro.…”

Section: Polymersmentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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Self-assembled nanoparticles based on hydrophobically modified chitosan as carriers for doxorubicin

Cited by 150 publications

References 25 publications

Review: doxorubicin delivery systems based on chitosan for cancer therapy

Review: doxorubicin delivery systems based on chitosan for cancer therapy

Possible role of nanocarriers in drug delivery against cervical cancer

Recent advances in materials for extended-release antibiotic delivery system

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