Recent advances in materials for extended-release antibiotic delivery system

Gao, Ping; Nie, Xin; Zou, Meijuan; Shi, Yijie; Cheng, Gang

doi:10.1038/ja.2011.58

Cited by 262 publications

(196 citation statements)

References 83 publications

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“…[19][20][21] CNT possess certain advantages over other antimicrobial agents: they are highly stable, do not leach over time, are easy to functionalize, and are proving to be compatible with human cell lines.…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotube bundling: influence on layer-by-layer assembly and antimicrobial activity

et al. 2013

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Antimicrobial surfaces are potentially useful for a variety of health care related applications. Single walled carbon nanotubes (SWNT) have shown promise as antimicrobial agents, but important questions persist concerning the effects of tube bundling, a common phenomenon owing to strong hydrophobicity. We investigate 15 here the influence of bundling on the layer-by-layer (LbL) assembly of SWNT with charged polymers, and on the antimicrobial properties of the resultant films. We employ a poly(ethylene glycol) functionalized phospholipid (PL-PEG) to disperse SWNT in aqueous solution, and consider cases where SWNT are dispersed i) as essentially isolated objects and ii) as small bundles. Quartz crystal microgravimetry 20 with dissipation (QCMD) and ellipsometry measurements show the bundled SWNT system to adsorb in an unusually strong fashion -with layers twice (when hydrated) and three times (when dried) as thick as those of isolated SWNT. Molecular dynamics simulation reveals a lower PL-PEG density and degree of solution extension on bundled versus isolated SWNT. These, and especially the lower polymer density 25 results in a lower degree of steric repulsion, which together with stronger van der Waals attraction, may explain the thicker adsorbed layers. Scanning electron micrographs reveal Escherichia coli on films with bundled SWNT to be essentially engulfed by the nanotubes, whereas the bacteria rest upon films with isolated SWNT. While both systems inactivate 90% of bacteria in 24 h, the bundled SWNT system is 30 "fast-acting," reaching this inactivation rate in 1 h. This study demonstrates the significant impact of SWNT bundling on LbL assembly, explores its microscopic origins, and illustrates its use toward bacteria-engulfing, fast-acting, antimicrobial coatings. IntroductionThe impressive physical, mechanical, chemical, electronic, and optical properties of carbon nanotubes (CNT) have established them as a primary research focus since their discovery by Iijima. 1 Research has focussed on developing applications in energy production and storage systems, 2 reinforcements for highperformance composites, 3 sensing materials, 4, 5 drug delivery vehicles, 6, 7 cancer therapeutics, 8,9 and antimicrobial agents. 10,11 Although discovered only recently, the antimicrobial activity of CNT has attracted significant attention. [11][12][13][14][15][16][17] Antimicrobial materials are designed to kill bacteria, and could be used to prevent the infection of medical devices. There are approximately 2 million cases of nosocomial infections in the US annually, and half are associated with implantable devices.18 Thus far, the focus has been primarily on bio-inspired antimicrobial surfaces such as antimicrobial peptides, bacteriolytic enzymes and essential oils, antimicrobial polymers with protonated amine groups, and various antibiotics. [19][20][21] CNT possess certain advantages over other antimicrobial agents: they are highly stable, do not leach over time, are easy to functionalize, and are proving to be compatible with ...

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Section: Introductionmentioning

confidence: 99%

Carbon nanotube bundling: influence on layer-by-layer assembly and antimicrobial activity

et al. 2013

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“…15,16 Nanoparticles can also be exploited to facilitate sustained release of an antibiotic, minimizing dosing regimens. 17 Furthermore, nanoparticles can mask the entrapped drug, reducing systemic toxicity induced by conventional administration of the free drug. 18 Moreover, polymeric nanoparticles have shown to enhance the oral bioavailability of orally inactive antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection

Abdelghany¹,

Quinn²,

Ingram³

et al. 2012

IJN

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Abstract:Gentamicin is an aminoglycoside antibiotic commonly used for treating Pseudomonas infections, but its use is limited by a relatively short half-life. In this investigation, developed a controlled-release gentamicin formulation using poly(lactide-co-glycolide) (PLGA) nanoparticles. We demonstrate that entrapment of the hydrophilic drug into a hydrophobic PLGA polymer can be improved by increasing the pH of the formulation, reducing the hydrophilicity of the drug and thus enhancing entrapment, achieving levels of up to 22.4 µg/mg PLGA. Under standard incubation conditions, these particles exhibited controlled release of gentamicin for up to 16 days. These particles were tested against both planktonic and biofilm cultures of P. aeruginosa PA01 in vitro, as well as in a 96-hour peritoneal murine infection model. In this model, the particles elicited significantly improved antimicrobial effects as determined by lower plasma and peritoneal lavage colony-forming units and corresponding reductions of the surrogate inflammatory indicators interleukin-6 and myeloperoxidase compared to free drug administration by 96 hours. These data highlight that the controlled release of gentamicin may be applicable for treating Pseudomonas infections.

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“…This poor compliance often leads to treatment failure and increases the costs of health-care resources such as the requirement for additional agents and hospital admission. By maintaining a constant plasma drug concentration over the MICpem for a prolonged period, sustained-release approaches maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance [15].…”

Section: Bacterial Adhesionmentioning

confidence: 99%

Biofunctionalization of surfaces using polyelectrolyte multilayers

Hartmann¹,

Krastev²

2018

Nano Online

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Biomaterials play a central role in modern strategies in regenerative medicine and tissue engineering to restore the structure and function of damaged or dysfunctional tissue and to direct cellular behavior. Both biologically derived and synthetic materials have been extensively explored in this context. However, most materials when implanted into living tissue initiate a host response. Modern implant design therefore aims to improve implant integration while avoiding chronic inflammation and foreign body reactions, and thus loss of the intended implant function. Directing these processes requires an in-depth understanding of the immunological processes that take place at the interface between biomaterials and the host tissue. The physicochemical properties of biomaterial surfaces (charge, charge density, hydrophilicity, functional molecular domains, etc.) are decisive, as are their stiffness, roughness and topography. This review outlines specific strategies, using polyelectrolyte multilayers to modulate the interactions between biomaterial surfaces and biological systems. The described coatings have the potential to control the adhesion of proteins, bacteria and mammalian cells. They can be used to decrease the risk of bacterial infections occurring after implantation and to achieve better contact between biological tissue and implants. In summary, these results are important for further development and modification of surfaces from different medical implants.

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Recent advances in materials for extended-release antibiotic delivery system

Cited by 262 publications

References 83 publications

Carbon nanotube bundling: influence on layer-by-layer assembly and antimicrobial activity

Carbon nanotube bundling: influence on layer-by-layer assembly and antimicrobial activity

Gentamicin-loaded nanoparticles show improved antimicrobial effects towards Pseudomonas aeruginosa infection

Biofunctionalization of surfaces using polyelectrolyte multilayers

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