Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles

Strydom, Schalk J.; Otto, Daniel P.; Stieger, Nicóle; Aucamp, Marique; Liebenberg, Wilna; Villiers, Melgardt M. de

doi:10.1016/j.powtec.2014.01.088

Cited by 19 publications

(17 citation statements)

References 25 publications

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“…40 The surface coating of drug particles can offer many advantages to the underlying drug including: targeted delivery, protection against degradation, a method to control release, and the possibility to arrest drug crystallization. 41,42 Early studies demonstrated that LbL coating on microcrystals of ibuprofen could delay drug release by tailoring coating thickness, crystal size and material solubility. 43 More recently, doxorubicin containing liposomes have been modified by the addition of PLA/siRNA multilayers on the outer surface of the nanoparticles.…”

Section: Structurementioning

confidence: 99%

Nanocoating for biomolecule delivery using layer-by-layer self-assembly

et al. 2015

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Since its introduction in the early 1990s, layer-by-layer (LbL) self-assembly of films has been widely used in the fields of nanoelectronics, optics, sensors, surface coatings, and controlled drug delivery. The growth of this industry is propelled by the ease of film manufacture, low cost, mild assembly conditions, precise control of coating thickness, and versatility of coating materials. Despite the wealth of research on LbL for biomolecule delivery, clinical translation has been limited and slow. This review provides an overview of methods and mechanisms of loading biomolecules within LbL films and achieving controlled release. In particular, this review highlights recent advances in the development of LbL coatings for the delivery of different types of biomolecules including proteins, polypeptides, DNA, particles and viruses. To address the need for co-delivery of multiple types of biomolecules at different timing, we also review recent advances in incorporating compartmentalization into LbL assembly. Existing obstacles to clinical translation of LbL technologies and enabling technologies for future directions are also discussed.

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Section: Structurementioning

confidence: 99%

Nanocoating for biomolecule delivery using layer-by-layer self-assembly

et al. 2015

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“…When water is employed as the continuous phase, the stabilizer can be directly dissolved in it . Alternatively, if the emulsification is performed in another immiscible organic solvent ( e.g ., eucalyptol or n ‐heptan), the obtained particles can be collected by centrifugation and then suspended in the aqueous phase . For example, nanocores of hydrophobic drugs (i.e., paclitaxel, nifedipine, furosemide, or isoxyl) of 65–170 nm in diameter were obtained for LbL assembly with the latter method and without the use of any stabilizers during core formation process …”

Section: Hydrophobic Drugsmentioning

confidence: 99%

Layer‐by‐Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties

Połomska

Leroux

2016

Macromolecular Bioscience

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Layer-by-layer coating is a simple and versatile technique based on the sequential deposition of molecular species on planar surfaces or colloidal templates. Its relevance in drug delivery primarily emerges from its versatility to control the release rate of the cargo encapsulated within the colloidal core. The focus of this review is the layer-by-layer encapsulation of colloidal particles purely composed of drug, including the core fabrication step, coating materials and techniques, multilayer shell permeability control, and reported in vitro and in vivo outcomes.

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“…By applying constant ultrasonication and step-wise addition of polyelectrolytes, 200–250 nm nanocrystals of PTX, tamoxifen, curcumin, resveratrol were successfully coated with two bilayer shells of biopolyelectrolytes (alginic acid, chitosan, heparin (Hep), poly-L-lysine (PLL), and proteins (protamine sulfate, BSA) [8, 10–13]. A coating consisted of 1.5–2 chitosan/chondroitin sulfate bilayers was required to produce stable 130–200 nm colloids of furosemide, PTX, isoxyl, and nefidipine and suppress for at least 3 months their growth in suspension due to the Ostwald ripening [14]. The current LbL approach has an advantage as compared with nano-encapsulation through direct ultrasonication of low soluble drugs microparticles suggested earlier [15].…”

Section: Polyelectrolyte Coated Drug Nanocarriersmentioning

confidence: 99%

“…Drug release from nanoparticulates is usually faster than from micronized powders due to smaller particles size [14, 16]. De Villeirs et al [14] found that the dissolution rate of poorly water soluble drugs from nanocapsules in PBS buffer decreases almost linearly with increasing shell thickness.…”

Section: Polyelectrolyte Coated Drug Nanocarriersmentioning

confidence: 99%

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Spherical and tubule nanocarriers for sustained drug release

Shutava

Fakhrullin

Lvov

2014

Current Opinion in Pharmacology

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We discuss new trends in Layer-by-Layer (LbL) encapsulation of spherical and tubular cores of 50–150 nm diameter and loaded with drugs. This core size decrease (from few micrometers to a hundred of nanometers) for LbL encapsulation required development of sonication assistant non-washing technique and shell PEGylation to reach high colloidal stability of drug nanocarriers at 2–3 mg/mL concentration in isotonic buffers and serum. For 120–170 nm spherical LbL nanocapsules of low soluble anticancer drugs, polyelectrolyte shell thickness controls drug dissolution. As for nanotube carriers, we concentrated on natural halloysite clay nanotubes as cores for LbL encapsulation that allows high drug loading and sustains its release over tens and hundreds hours. Further drug release prolongation was reached with formation of the tube-end stoppers.

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Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles

Cited by 19 publications

References 25 publications

Nanocoating for biomolecule delivery using layer-by-layer self-assembly

Nanocoating for biomolecule delivery using layer-by-layer self-assembly

Layer‐by‐Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties

Spherical and tubule nanocarriers for sustained drug release

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