Layer‐by‐Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties

Połomska, Anna; Leroux, Jean‐Christophe

doi:10.1002/mabi.201600228

Cited by 16 publications

(6 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, the star polymer existed in the glassy state, resulting in reduced DNA transfection as compared to when rubbery polymers were utilized . Traditional methods of polymeric drug delivery simply encapsulates drugs to the hydrophobic cores, but this is often plagued by problems of early release or poor delivery as the micelles may start to degrade and unload the drugs before reaching their targets . This method is also usually characterized by low drug loading capacities.…”

Section: Applications Of Star‐shaped Polymersmentioning

confidence: 99%

“…drugs to the hydrophobic cores, but this is often plagued by problems of early release or poor delivery as the micelles may start to degrade and unload the drugs before reaching their targets. [35,158,[161][162][163][164][165][166][167] This method is also usually characterized by low drug loading capacities. To deal with this problem, newer methods involve the conjugation of drugs to the poly mer chains through covalent chemical bonding.…”

Section: Latesmentioning

confidence: 99%

See 1 more Smart Citation

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

121

View full text Add to dashboard Cite

With the advancement of polymer engineering, complex star-shaped polymer architectures can be synthesized with ease, bringing about a host of unique properties and applications. The polymer arms can be functionalized with different chemical groups to fine-tune the response behavior or be endowed with targeting ligands or stimuli responsive moieties to control its physicochemical behavior and self-organization in solution. Rheological properties of these solutions can be modulated, which also facilitates the control of the diffusion of the drug from these star-based nanocarriers. However, these star-shaped polymers designed for drug delivery are still in a very early stage of development. Due to the sheer diversity of macromolecules that can take on the star architectures and the various combinations of functional groups that can be cross-linked together, there remain many structure-property relationships which have yet to be fully established. This review aims to provide an introductory perspective on the basic synthetic methods of star-shaped polymers, the properties which can be controlled by the unique architecture, and also recent advances in drug delivery applications related to these star candidates.

show abstract

Section: Applications Of Star‐shaped Polymersmentioning

confidence: 99%

Section: Latesmentioning

confidence: 99%

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Yang

Deen

et al. 2017

Macromol. Rapid Commun.

121

View full text Add to dashboard Cite

show abstract

“…A key application of polyelectrolytes for this work is their ability to produce ultra-thin coatings through electrostatic deposition and layer-by-layer assembly [ 19 ]. The ultra-thin coatings have been used to control drug release [ 20 ], stabilize drug delivery vehicles [ 21 ], and protect medical devices from causing fungal infections [ 22 ]. This work is concerned with the applications of polyelectrolytes in stabilizing amorphous drugs.…”

Section: Introductionmentioning

confidence: 99%

Amorphous Drug-Polymer Salts

Yao

Neusaenger

2021

Pharmaceutics

View full text Add to dashboard Cite

Amorphous formulations provide a general approach to improving the solubility and bioavailability of drugs. Amorphous medicines for global health should resist crystallization under the stressful tropical conditions (high temperature and humidity) and often require high drug loading. We discuss the recent progress in employing drug–polymer salts to meet these goals. Through local salt formation, an ultra-thin polyelectrolyte coating can form on the surface of amorphous drugs, immobilizing interfacial molecules and inhibiting fast crystal growth at the surface. The coated particles show improved wetting and dissolution. By forming an amorphous drug–polymer salt throughout the bulk, stability can be vastly enhanced against crystallization under tropical conditions without sacrificing the dissolution rate. Examples of these approaches are given, along with suggestions for future work.

show abstract

“…Active agents can be assembled either into the core or the multilayer. Additionally, functional components, such as surface-assembled peptides or antibodies can be independently added, which allows for control of the time-point of drug release and of the amount of the delivered drugs [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Metabolic Response of Various Cell Lines to Microtubule-Driven Uptake of Lipid- and Polymer-Coated Layer-by-Layer Microcarriers

et al. 2021

View full text Add to dashboard Cite

Lipid structures, such as liposomes or micelles, are of high interest as an approach to support the transport and delivery of active agents as a drug delivery system. However, there are many open questions regarding their uptake and impact on cellular metabolism. In this study, lipid structures were assembled as a supported lipid bilayer on top of biopolymer-coated microcarriers based on the Layer-by-Layer assembly strategy. The functionalized microcarriers were then applied to various human and animal cell lines in addition to primary human macrophages (MΦ). Here, their influence on cellular metabolism and their intracellular localization were detected by extracellular flux analysis and immunofluorescence analysis, respectively. The impact of microcarriers on metabolic parameters was in most cell types rather low. However, lipid bilayer-supported microcarriers induced a decrease in oxygen consumption rate (OCR, indicative for mitochondrial respiration) and extracellular acidification rate (ECAR, indicative for glycolysis) in Vero cells. Additionally, in Vero cells lipid bilayer microcarriers showed a more pronounced association with microtubule filaments than polymer-coated microcarrier. Furthermore, they localized to a perinuclear region and induced nuclei with some deformations at a higher rate than unfunctionalized carriers. This association was reduced through the application of the microtubule polymerization inhibitor nocodazole. Thus, the effect of respective lipid structures as a drug delivery system on cells has to be considered in the context of the respective target cell, but in general can be regarded as rather low.

show abstract

Layer‐by‐Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties

Cited by 16 publications

References 124 publications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Nano‐Star‐Shaped Polymers for Drug Delivery Applications

Amorphous Drug-Polymer Salts

The Metabolic Response of Various Cell Lines to Microtubule-Driven Uptake of Lipid- and Polymer-Coated Layer-by-Layer Microcarriers

Contact Info

Product

Resources

About