Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus

Zhang, Qianqian; Li, Wenxia; Wang, Jian; Hu, Bi-yue; Yun, Hang; Guo, Renmei; Wang, Li

doi:10.1007/s12011-019-1645-6

Cited by 15 publications

(8 citation statements)

References 40 publications

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“…The overall results of the nine T2D studies included in our meta-analysis [ 18 , 19 , 43 , 44 , 56 ] showed that the SELENOP concentrations in T2D were similar to those without T2D, which was inconsistent with the results of the previous meta-analysis studies on the relationship between Se and T2D [ 27 , 28 , 88 , 89 ], suggesting disparity between Se and SELENOP in their associations with diseases. In previous studies, the investigators suggested that there was a U-shaped relationship between Se and T2D.…”

Section: Discussioncontrasting

confidence: 96%

“…In the first step of searching for published studies, 1967 articles were selected from the proposed search databases, and 1 [ 43 ] from the listed references in 1 of those articles [ 44 ]. After careful review, we excluded 607 duplicate articles and 1220 articles that did not meet the inclusion criteria (assessed by their study titles and abstracts).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 141 articles, we further excluded 114 articles without detail or eligible data for meta-analysis due to unsearchable full-texts ( n = 11), animal or cellular studies ( n = 13), reviews ( n = 48), and others ( n = 42). Finally, 27 articles [ 15 , 17 , 18 , 19 , 22 , 23 , 24 , 25 , 26 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ] were included in the meta-analysis ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Either a significantly decreased or elevated Se level, lower or higher than the normal physiological range, should be considered as a risk factor for T2D [ 90 , 91 , 92 , 93 ]. Of the two included studies for our meta-analysis that simultaneously measured the concentrations of Se and SELENOP [ 43 , 44 ], both Se and SELENOP did not differ between the patients and controls when the mean plasma Se was about 80 µg/L [ 43 ], but both were significantly higher in patients than in the controls when the mean serum Se was > 94 µg/L [ 44 ]. However, in another recently published cohort study that did not meet our inclusion criteria, the serum Se (with median value at 80 µg/L), but not SELENOP, was associated with increased risk of developing T2D in the final adjustment model [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

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Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Wang

et al. 2022

Antioxidants

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Selenoprotein P (SELENOP) is an extracellular antioxidant, selenium transporter, and hepatokine interfering with glucose and lipid metabolism. To study the association between the circulating SELENOP concentration and glucose and lipid metabolic diseases (GLMDs), including gestational diabetes (GD), metabolic syndrome (MetS), non-alcoholic fatty liver disease, obesity, and type 2 diabetes, as well as the individual markers, a meta-analysis was conducted by searching multiple databases from their establishment through March 2022 and including 27 articles published between October 2010 and May 2021, involving 4033 participants. Participants with GLMDs had higher levels of SELENOP than those without GLMDs (standardized mean difference = 0.84, 95% CI: 0.16 to 1.51), and the SELENOP levels were positively correlated with the markers of GLMDs (pooled effect size = 0.09, 95% CI: 0.02 to 0.15). Subgroup analyses showed that the SELENOP concentrations were higher in women with GD and lower in individuals with MetS than their counterparts, respectively. Moreover, SELENOP was positively correlated with low-density lipoprotein cholesterol, but not with the other markers of GLMDs. Thus, the heterogenicity derived from diseases or disease markers should be carefully considered while interpreting the overall positive association between SELENOP and GLMDs. Studies with a larger sample size and advanced design are warranted to confirm these findings.

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Section: Discussioncontrasting

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Wang

et al. 2022

Antioxidants

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“…Alguns estudos têm mostrado alterações corporais de selênio em indivíduos com doenças crônicas degenerativas, como diabetes mellitus tipo 2, hipotireoidismo congênito e câncer Zhang et al (2019); Khan, Bule, Rahman, Asif, Niaz et al (2019); Rostami, Fathollahpour, Abdi, Naderi (2018). Também têm sido observado a deficiência de Se em múltiplas perturbações metabólicas, como na hiperglicemia, na hiperlipidemia e na hiperfenilalaninemia e, além disso, a suplementação deste pode contribuir com a melhora de parâmetros de biomarcadores relacionados à aterosclerose, hipercolesterolemia, diabetes mellitus tipo 1 e fenilcetonúria Wang et al (2017), além de melhorar as defesas antioxidantes em pacientes renais crônicos, a depender da quantidade ingerida Freitas et al (2020).…”

Section: Introductionunclassified

Determinação de selênio em leite bovino in natura provenientes do Ceará - Brasil

Assis

Nogueira

Pinheiro

et al. 2021

RSD

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O selênio é essencial para a saúde humana. Dentre os alimentos considerados fonte de selênio, estão as castanhas brasileiras, carnes, ovos, leites e outros, variando conforme a área geográfica de plantio ou criação do animal. Dados de Se em alimentos cultivados, industrializados e comercializados no Brasil são ausentes em tabelas de composição de alimentos brasileiras. O objetivo do estudo foi determinar a concentração de selênio em leite bovino in natura produzido no Ceará, região Nordeste do Brasil. Trata-se de uma pesquisa experimental, onde as amostras foram coletadas em municípios das principais bacias leiteiras do Ceará. As concentrações de selênio foram determinadas por Espectrofotometria de Absorção Atômica por Geração de Hidretos acoplado a cela de quartzo. Os teores de umidade, cinzas e proteína foram analisados segundo a metodologia da Association of Official Analytical Chemists (1980), o teor de lipídios por método de Soxhlet e a quantidade de carboidratos foi calculada por diferença. A média das concentrações de selênio, umidade, cinza, proteína, lipídio e carboidrato do leite bovino in natura foi de 2.9 µg/100mL, 89.0 mg/100 mL, 0.6 mg/100mL, 2.9 mg/100mL, 3.6 mg/100mL e 4.0 mg/100mL, respectivamente. A concentração de selênio no leite bovino in natura variou de 0.1-9.0 µg/100ml, sendo em algumas localidades superior em relação a outras localidades do Brasil e do mundo, podendo contribuir para o consumo deste mineral pela população do estado.

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Factors Influencing Selenium Concentration in Community-Dwelling Patients with Type 2 Diabetes Mellitus

Zhang

Wang

et al. 2020

Biol Trace Elem Res

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Selenium Levels in Community Dwellers with Type 2 Diabetes Mellitus

Cited by 15 publications

References 40 publications

Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Determinação de selênio em leite bovino in natura provenientes do Ceará - Brasil

Factors Influencing Selenium Concentration in Community-Dwelling Patients with Type 2 Diabetes Mellitus

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