Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Yu, Ruirui; Wang, Zhoutian; Ma, Miaomiao; Xu, Ping; Liu, Longjian; Tinkov, Alexey A.; Lei, Xin Gen; Zhou, Jinchuan

doi:10.3390/antiox11071263

Cited by 12 publications

(3 citation statements)

References 125 publications

(202 reference statements)

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“…Besides Se transporter, SELENOP as extracellular glycoprotein found abundantly in plasma comparing to other selenoproteins and has various other functions such as antioxidant response and Se homeostasis [51]. SELENOP concentration found to be signi cantly higher in subjects with glucose and lipid metabolic diseases (GLMDs) and gestational diabetes (GD) [52]. Diverse relationship between plasma selenium level and SELENOP polymorphism with various metabolic syndrome (MetS) including obesity, hypertriglyceridemia and high density lipoprotein cholesterol has been found indicating GA + AA and GA genotype of SELENOP rs7579 variant signi cantly associated with increased risk of MetS [34].…”

Section: Discussionmentioning

confidence: 99%

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Sharma,

Khetarpal

2024

Biol Trace Elem Res

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Selenium is a trace element and its de ciency has been associated with the risk of PCOS, a multifactorial syndrome that affects a large number of women worldwide. Several databases and literature were searched to nd out genetic variants of the genes involved in selenium uptake, metabolism and regulation which may be signi cantly associated with risk of PCOS through Se related pathways. Genes whish require selenium for their biological actions to perform were also shortlisted. A total of eighteen signi cantly associated genes were identi ed which were shortlisted among forty-four variants that could play potential role in the PCOS risk among the study population. The genetic variant distribution data was available in-house and was obtained through GWAS study of the North India population. In silico tools were applied to understand the functional impact of these variants. Three variants namely LDLR(rs2228671), TNF (rs1041981), and SAA2 (rs2468844) are strongly associated with PCOS risk and have a functional impact on encoded protein. Certain variants of Se uptake genes such as DIO1, GPX2, TXNRD1, DIO2 GPX3 genes signi cantly increase or decrease risk of PCOS development. Se transporter gene SELENOP polymorphism rs9686343 with C allele signi cantly increased PCOS risk. Other potential genes that require selenium for their biological actions are involved in the in ammatory, antioxidant response, and energy homeostasis signaling pathways. Thus genetic variants of the population may affect the Se availability or Se de ciency may modulate the effect of Se-associated genes due to genetic polymorphism. This information may be helpful in dosage adjustment of Se supplementation for a population in order to have maximum bene ts.

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Section: Discussionmentioning

confidence: 99%

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Sharma,

Khetarpal

2024

Biol Trace Elem Res

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“…Although the data provide evidence for a positive relationship between selenium status and positive outcomes, the overall evidence is limited. In two recent systematic reviews and meta-analyses it was found that serum levels of selenium were lower in patients with gestational diabetes (109), and preeclampsia was associated with lower levels of selenium (110). The latter could not be confirmed in a Norwegian birth cohort (111).…”

Section: Other Health Related Outcomesmentioning

confidence: 95%

Selenium – a scoping review for Nordic Nutrition Recommendations 2023

Alexander,

Olsen

2023

Food & Nutrition Research

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Selenium is an essential trace element in humans, critical to the normal physiology in all animal species. The main form of selenium in food is selenomethionine, selenocysteine and a variety of organic compounds, while inorganic salts mainly occur in food supplements. In animals and humans, selenium occurs as selenocysteine in selenoproteins encoded by 25 genes (specific selenium pool). Several selenoproteins are part of the antioxidant enzyme system and serve as oxido-reductases and in thyroid hormone regulation. SelenoproteinP (SELENOP) transports selenium to peripheral tissues, is the main plasma selenoprotein, and has been used as biomarker of selenium status and intake. SELENOP in plasma represents a saturable pool of selenium and is maximised at a selenium concentration in plasma of about 110 µg/L or an intake of selenomethionine at about 1.2 µg/kg body weight in adults. In Finland, with an estimated selenium intake of 88 µg/day in men and 68 µg/day in women, the average selenium concentration in plasma is about 110 µg/L. Imported wheat from selenium rich areas is an important dietary source in Norway. Dietary intakes in the Nordic and Baltic area vary from 39 to 88 µg/day in men and 22 to 68 µg/day in women, the highest levels were from Finland. Most intervention trials on the effect of selenium supplementation on health outcomes have been carried out in ‘selenium-replete’-populations and show no beneficial effect, which from a nutritional point of view would rather not be expected. Some intervention studies conducted in populations low in selenium have showed a beneficial effect. Observational studies suggest an inverse relationship between selenium status and risk of cardiovascular diseases (CVDs), cancer and all-cause mortality, and some other outcomes at low levels of intake (<55 µg/day) or in plasma or serum (<100 µg/L). However, a lack of quantitative data and inconsistencies between studies precludes these studies to be used to derive dietary reference values. At high intakes above 330 to 450 µg/day selenium may cause toxic effects affecting liver, peripheral nerves, skin, nails, and hair. An upper tolerable level (UL) of 255 µg selenium/day in adults was established by EFSA.

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“… 8 Selenoprotein P (SELENOP) is a plasma protein that functions as a selenium transport protein, delivering selenium to target tissues and organs. 9 Higher SELENOP concentrations have been associated with higher Hb concentrations, 10 suggesting a positive influence on erythropoiesis. 11 , 12 Further, higher levels of selenium have been demonstrated to be associated with lower risk of the development of HF, 13 and low levels of selenium and SELENOP are associated with poorer prognosis in patients with existing HF.…”

Section: Introductionmentioning

confidence: 99%

Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients

Jujić,

Molvin,

Holm Isholth

et al. 2024

ESC Heart Failure

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AimsHeart failure (HF) patients with anaemia tend to have a worse outcome, with increased hospitalization rates, decreased exercise tolerance, and higher mortality compared to those without anaemia. Limited research exists on the association between selenium deficiency and anaemia specifically in HF patients, despite previous findings of a correlation in different populations. The BIOSTAT‐CHF study demonstrated that higher selenium levels in HF patients were associated to a lower risk of anaemia and iron deficiency. This study investigates the relationship between selenoprotein P (SELENOP) concentrations, a major contributor and functional biomarker of selenium transport, and anaemia, Hb levels, and iron status in hospitalized HF patients.Methods and resultsSELENOP was analysed in 320 hospitalized HF subjects, with complete data available for 310 subjects. The relationships between continuous SELENOP concentrations and 1) Hb concentrations, 2) anaemia (Hb < 115 g/L (women), <130 g/L (men)), and 3) iron status (as measured by transferrin receptor 1 (TfR1) which increases in iron deficiency) were evaluated using multivariable logistic and linear regression models. Additionally, SELENOP concentrations in the lowest quartile were related to anaemia, haemoglobin, and iron state in multivariable logistic and linear models. The mean age of the study population was 75.0 ± 11.6 years, and 30% were women. Anaemia was present in 133 subjects (42.9%). SELENOP concentrations were positively correlated with haemoglobin concentrations (0.238; P < 0.001) and negatively with TfR1 concentrations (−0.238, P < 0.001). In multivariable regression models, higher SELENOP concentrations were associated with higher Hb concentrations (B = 3.23; P = 0.002) and lower TfR1 concentrations (B = −0.20; P < 0.001). Furthermore, SELENOP deficiency was associated with lower Hb concentrations (B = −7.64: P = 0.001), higher TfR1 concentrations (B = 0.31; P = 0.003), and higher odds of anaemia in HF patients (odds ratio 2.17; 95% confidence interval 1.23–3.82; P = 0.008).ConclusionsIn hospitalized heart failure patients, lower concentrations of SELENOP were associated with higher prevalence of anaemia.

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Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis

Cited by 12 publications

References 125 publications

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Genetic Determinants of Selenium Availability, Selenium-Response, and Risk of Polycystic Ovary Syndrome

Selenium – a scoping review for Nordic Nutrition Recommendations 2023

Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients

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