2008
DOI: 10.1002/ab.20253
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Abstract: Alpha-2 adrenoceptors (alpha(2)-ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons and play an important role in the regulation of awareness, arousal and vigilance. In our recent study, dexmedetomidine, a full alpha(2)-AR agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. The aim of this study was to ascertain antiaggressive effect of a novel drug naphthylmedetomidine, … Show more

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Cited by 4 publications
(8 citation statements)
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References 40 publications
(47 reference statements)
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“…This is the first report on the use of naphthylmedetomidine in rabbits. This and the recently published study (Votava et al. 2008), indicate that less sedation is induced by naphthylmedetomidine compared with medetomidine.…”
Section: Discussionsupporting
confidence: 80%
See 1 more Smart Citation
“…This is the first report on the use of naphthylmedetomidine in rabbits. This and the recently published study (Votava et al. 2008), indicate that less sedation is induced by naphthylmedetomidine compared with medetomidine.…”
Section: Discussionsupporting
confidence: 80%
“…1994). The sedative and anti‐aggressive effects of this drug have been reported (Votava et al. 2008).…”
Section: Introductionmentioning
confidence: 99%
“…, Lynch et al (2011), MacDonald et al (1991), Moore et al (1992), O'Dell et al (2000), Oduola et al (2004), Philibin et al (2005), Rasmussen and Fink-Jensen (2000),Redrobe and Bourin (1997),Simon et al (2000),Vanderwolf (1991),Vanover et al (2006),Votava et al (2008),Yan et al (2007),Zarnowski et al (1994), andZhu et al (2004).…”
mentioning
confidence: 99%
“…Because of the central sympatholytic effect, medetomidine causes a drop in blood pressure and bradycardia [6, 9]. The effect of naphthylmedetomidine has been described as qualitatively different from the effects of medetomidine or dexmedetomidine in mice, rabbits, or rhesus macaques [3, 10, 11]. Depending on the dose, naphthylmedetomidine reduces the frequency and length of aggression in aggressive mice, increasing their latency period from the first instance.…”
Section: Discussionmentioning
confidence: 99%
“…At comparable doses, naphthylmedetomidine is not expected to produce the large and widespread effects that are otherwise seen with full and highly specific α 2 ‐AR agonists, such as medetomidine or dexmedetomidine [4, 13]. Recently, its effects on behavioral profile in mice [10] and cardiorespiratory function in rabbits [3] and rhesus macaques [11] have been described. The experiments with mice found that naphthylmedetomidine, even in the smallest doses, considerably impacted aggression, while locomotor activities were retained.…”
Section: Introductionmentioning
confidence: 99%