The effect of the novel alpha–2–adrenoceptor agonist naphthylmedetomidine on pulse rate, arterial blood pressure and sedation in rabbits

Experience with a naphthylmedetomidine – ketamine – hyaluronidase combination in inducing immobilization in anthropoid apes

“…Because of the central sympatholytic effect, medetomidine causes a drop in blood pressure and bradycardia [6, 9]. The effect of naphthylmedetomidine has been described as qualitatively different from the effects of medetomidine or dexmedetomidine in mice, rabbits, or rhesus macaques [3, 10, 11]. Depending on the dose, naphthylmedetomidine reduces the frequency and length of aggression in aggressive mice, increasing their latency period from the first instance.…”

“…At comparable doses, naphthylmedetomidine is not expected to produce the large and widespread effects that are otherwise seen with full and highly specific α 2 ‐AR agonists, such as medetomidine or dexmedetomidine [4, 13]. Recently, its effects on behavioral profile in mice [10] and cardiorespiratory function in rabbits [3] and rhesus macaques [11] have been described. The experiments with mice found that naphthylmedetomidine, even in the smallest doses, considerably impacted aggression, while locomotor activities were retained.…”