2009
DOI: 10.1111/j.1467-2995.2008.00442.x
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The effect of the novel alpha–2–adrenoceptor agonist naphthylmedetomidine on pulse rate, arterial blood pressure and sedation in rabbits

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Cited by 1 publication
(2 citation statements)
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“…Because of the central sympatholytic effect, medetomidine causes a drop in blood pressure and bradycardia [6, 9]. The effect of naphthylmedetomidine has been described as qualitatively different from the effects of medetomidine or dexmedetomidine in mice, rabbits, or rhesus macaques [3, 10, 11]. Depending on the dose, naphthylmedetomidine reduces the frequency and length of aggression in aggressive mice, increasing their latency period from the first instance.…”
Section: Discussionmentioning
confidence: 99%
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“…Because of the central sympatholytic effect, medetomidine causes a drop in blood pressure and bradycardia [6, 9]. The effect of naphthylmedetomidine has been described as qualitatively different from the effects of medetomidine or dexmedetomidine in mice, rabbits, or rhesus macaques [3, 10, 11]. Depending on the dose, naphthylmedetomidine reduces the frequency and length of aggression in aggressive mice, increasing their latency period from the first instance.…”
Section: Discussionmentioning
confidence: 99%
“…At comparable doses, naphthylmedetomidine is not expected to produce the large and widespread effects that are otherwise seen with full and highly specific α 2 ‐AR agonists, such as medetomidine or dexmedetomidine [4, 13]. Recently, its effects on behavioral profile in mice [10] and cardiorespiratory function in rabbits [3] and rhesus macaques [11] have been described. The experiments with mice found that naphthylmedetomidine, even in the smallest doses, considerably impacted aggression, while locomotor activities were retained.…”
Section: Introductionmentioning
confidence: 99%