Experience with a naphthylmedetomidine – ketamine – hyaluronidase combination in inducing immobilization in anthropoid apes

Abstract

Naphthylmedetomidine could replace medetomidine for inducing immobilization and sedation. A combination of naphthylmedetomidine-ketamine is suitable for relocating animals to other cages or for painless medical examinations.

Short term pharmacological immobilization in macaque monkeys

“…2004). Our previous results (Hess et al. 2010) and published studies in other species have shown that medetomidine alone induces a long period of sedation with a decrease in the respiratory rate and of arterial oxygen saturation (Sinclair 2003).…”

“…In primates the most commonly described immobilization protocols are based on the administration of dissociative anaesthetic agents including ketamine, often combined with medetomidine (Sun et al 2003) and the combination of tiletamine with zolazepam (Bentson et al 2003). In our laboratory we have described the combined immobilization effect of medetomidine or its derivative naphthylmedetomidine with midazolam and ketamine in anthropoid apes (Hess et al 2010) and rhesus monkeys (Votava et al 2009). However, the dissociative anaesthetic agents are known to cause many adverse reactions, among which salivation and hypertonic reactions are the most disturbing.…”

“…2003). In our laboratory we have described the combined immobilization effect of medetomidine or its derivative naphthylmedetomidine with midazolam and ketamine in anthropoid apes (Hess et al. 2010) and rhesus monkeys (Votava et al.…”

Chemical immobilization of chimpanzees (Pan troglodytes) using a combination of detomidine and ketamine

“…(2004a,b) describe the use of dexmedetomidine in primates, but the currently available commercial formulation offers no volume reduction compared to standard preparations of medetomidine (1 mg mL −1 ). Hess et al. (2010) describe the use of naphthylmedetomidine in a 10 mg mL −1 formulation, resulting in a low volume, with promising cardiovascular and behavioural effects of for non‐painful procedures in primates.…”

“…1982) and, more recently, medetomidine (Adams et al. 2003; Lewis 1993) and naphthylmedetomidine (Hess et al. 2010).…”