Secretory Fluid‐Aggregated Janus Electrospun Short Fiber Scaffold for Wound Healing

Abstract

Exudate management is critical to improve chronic wound healing. Herein, inspired by a Janus‐structured lotus leaf with asymmetric wettability, a Janus electrospun short fiber scaffold is fabricated via electrospinning technologies and short fiber modeling. This scaffold is composed of hydrophilic 2D curcumin‐loaded electrospun fiber and hydrophobic 3D short fiber via layer‐by‐layer assembly and electrostatic interactions which can aggregate the wound exudate by pumping from the hydrophobic layer to the hydrophilic via multiple contact points between hydrophilic and hydrophobic fibers, and simultaneously trigger the cascade release of curcumin in the upper 2D electrospun fiber. The 3D short fiber with high porosity and hydrophobicity can quickly aggregate exudate within 30 s after compounding with hydrophilic 2D electrospun fiber via a spontaneous pump. In vitro experiments show that Janus electrospun short fiber has good biocompatibility, and the cascade release of curcumin can significantly promote the proliferation and migration of fibroblasts. In vivo experiments show that it can trigger cascade release of curcumin by aggregating wound exudate, so as to accelerate wound healing process and promote collagen deposition and vascularization. Hence, this unique biometric Janus scaffold provides an alternative for chronic wound healing.

Porous Silicon Carrier Endowed with Photothermal and Therapeutic Effects for Synergistic Wound Disinfection

“…As shown in Figure d,e, the CuPPSi showed faster scratch healing with an approximately 2.7-fold migration rate in comparison to the control group. The results might be attributed to the promotion effect of released Cu and Si ions on NIH3T3 cells migration. , In addition, the scratch region treated with CuPPSi-Cur was narrower than that of CuPPSi due to the effect of the Cur payload. − Notably, the cells treated with CuPPSi-Cur + NIR showed the highest migration capability because NIR light triggered the release of more therapeutic agents including Cur (1.84% of initial amount of payload) and Cu 2+ (6.92 ppm). These results reveal that the NIR-irradiated CuPPSi-Cur not only has negligible cytotoxicity but also promotes the function of cell migrating.…”

Polysaccharide Electrospun Nanofibers for Wound Healing Applications

“…Therefore, the development of wound dressings with specific functions such as antibacterial, anti-inflammatory, promotion of cell proliferation and migration, and promotion of angiogenesis can correct the disrupted stages of wound healing and guide the wound to follow an orderly healing procedure. 96,97 https://doi.org/10.2147/IJN.S371900…”

Recent advancements in wound management: Tailoring superwettable bio-interfaces

“…After the coverage of hydrophobic curcumin-loaded PCL, the hybrid dressing was utilized for diabetic wound therapy by virtue of antibacterial, antioxidant, and fluid gating characteristics. From another perspective, Qian et al raised the management of exudate by the collection of wound exudate in the early stage, followed by the cascade release of drug (curcumin) from the hydrophilic substrates ( Qian et al, 2022 ). The inverse effects of the hydrophilic layers in above two works might be attributed to diverse absorption capabilities of hydrophilic substrates and different blocking ability of hydrophobic layer.…”