Polysaccharide Electrospun Nanofibers for Wound Healing Applications

Tan, Guoxin; Wang, Lijie; Pan, Weisan; Chen, Kai

doi:10.2147/ijn.s371900

Cited by 44 publications

(15 citation statements)

References 149 publications

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“…Calcium ions help convert prothrombin to thrombin, accelerating the formation of blood clots and catalyzing many other coagulation-related reactions. It was observed that the highest coagulation rate was observed in polycaprolactone nanofibers with CaCO 3 content coated with β-chitosan [39].…”

Section: Discussionmentioning

confidence: 99%

Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect

et al. 2023

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Poly-ε-caprolactone (PCL) is a biodegradable aliphatic polyester that can be used in the field of biomaterials. Electrospinning is the name given to the process of producing micro and nanoscale fibers using electrostatically charged polymeric solutions under certain conditions. Almost all synthetic and naturally occurring polymers can undergo electrospinning using suitable solvents or mixtures prepared in certain proportions. In this study, silica aerogels were obtained by the sol-gel method. PCL-silica aerogel fibers were synthesized by adding 0.5, 1, 2, and 4% ratios in the PCL solution. Blood contact analysis was performed on the produced fibers with UV-VIS. According to the results obtained, 0.5, 1, 2, and 4% nano-silver were added to the fiber-containing 4% aerogel. Then, SEM-EDS and FTIR analyses were performed on all fibers produced. Antimicrobial tests were performed on fibers containing nano-silver. As a result, high-performance blood coagulation fibers were developed using PCL with aerogel, and an antimicrobial effect was achieved with nano-silver particles. It is thought that the designed surface will be preferred in wound dressing and biomaterial in tissue engineering, as it provides a high amount of cell adhesion with a small amount of blood and contains antimicrobial properties.

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Section: Discussionmentioning

confidence: 99%

Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect

et al. 2023

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“…Starch is a carbohydrate type of polymer that is explored in different biomedical applications, such as wound healing due to its biocompatibility, availability, and low cost. It has also been used for cell adhesion, proliferation, and regeneration, hence starch-based scaffolds have great therapeutic significance in wound healing applications [ 64 , 65 ]. Some undesirable properties of starch, such as its sensitivity to moisture and mechanical strength negatively, impact its application in tissue engineering, however, polyvinyl alcohol can be used as a plasticizer in its electrospinning process.…”

Section: Polymers Used In the Fabrication Of Nanofibrous Scaffoldsmentioning

confidence: 99%

Nanofibrous Scaffolds for Diabetic Wound Healing

Aliyu

Adeleke

2023

Pharmaceutics

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Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays in the wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining blood glucose concentration within normal ranges, but this can be quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care to prevent complications such as sepsis, amputation, and deformities, which often develop in these patients. Although several conventional wound dressings, such as hydrogels, gauze, films, and foams, are employed in the treatment of such chronic wounds, nanofibrous scaffolds have gained the attention of researchers because of their flexibility, ability to load a variety of bioactive compounds as single entities or combinations, and large surface area to volume ratio, which provides a biomimetic environment for cell proliferation relative to conventional dressings. Here, we present the current trends on the versatility of nanofibrous scaffolds as novel platforms for the incorporation of bioactive agents suitable for the enhancement of diabetic wound healing.

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“…At the same time, there are still large pores in these traditional dressings, which cannot avoid the contact between bacteria in the air and the wound ( Simões et al, 2018 ; Obagi et al, 2019 ). With the development of time, modern dressings represented by hydrogels, fiber dressings, foam dressings and film dressings are gradually applied in clinical practice ( Walker et al, 2017 ; Liang et al, 2021a ; Tan et al, 2022 ). These dressings can create a moist surface environment for the wound and prevent bacteria from passing through the dressing and entering the wound while ensuring gas exchange ( Francesko et al, 2018 ).…”

Section: Characteristics Of Wound Dressing In Skin Wound Healingmentioning

confidence: 99%

Applications of MXene and its modified materials in skin wound repair

Zhang

Kong

et al. 2023

Front. Bioeng. Biotechnol.

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The rapid healing and repair of skin wounds has been receiving much clinical attention. Covering the wound with wound dressing to promote wound healing is currently the main treatment for skin wound repair. However, the performance of wound dressing prepared by a single material is limited and cannot meet the requirements of complex conditions for wound healing. MXene is a new two-dimensional material with electrical conductivity, antibacterial and photothermal properties and other physical and biological properties, which has a wide range of applications in the field of biomedicine. Based on the pathophysiological process of wound healing and the properties of ideal wound dressing, this review will introduce the preparation and modification methods of MXene, systematically summarize and review the application status and mechanism of MXene in skin wound healing, and provide guidance for subsequent researchers to further apply MXene in the design of skin wound dressing.

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Polysaccharide Electrospun Nanofibers for Wound Healing Applications

Cited by 44 publications

References 149 publications

Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect

Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect

Nanofibrous Scaffolds for Diabetic Wound Healing

Applications of MXene and its modified materials in skin wound repair

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