Porous Silicon Carrier Endowed with Photothermal and Therapeutic Effects for Synergistic Wound Disinfection

Abstract

Drug carriers endowed with photothermal effects will allow the drug delivery system to release drugs in a thermal-stimuli manner. In addition, the photothermal therapy (PTT) will also interplay with therapeutic drugs loaded in the carrier to exhibit synergistic bioactivity for various disease treatment. However, endowing the drug carrier with photothermal and synergistic therapeutic effects still has challenge. Herein, we demonstrate that surface modification of porous silicon (PSi) with polydopamine (PDA) could endow the classical drug carrier with a significant photothermal effect for advanced antibacterial therapy and wound disinfection. Specifically, the PSi surface interacts with a Cu2+/PDA complex via a simple and fast surface reduction-induced deposition method, forming the unique CuPDA coated PSi microcarrier (CuPPSi) without blocking the mesoporous structure. The CuPPSi carrier generates a higher near-infrared (NIR) photothermal efficiency and improved drug loading capacity owing to the abundant functional groups of PDA. Stimuli-responsive release of antibacterial Cu2+ and loaded curcumin (Cur) from CuPPSi can be realized under multiple stimuli including pH, reactive oxygen species and NIR laser irradition. Benefited from the carrier’s intrinsic multimodal therapy, the CuPPSi-Cur platform exhibits amplified, broad-spectrum, and synergistic antibacterial effect, killing more than 98% for both Staphylococcus aureus and Escherichia coli at a mild PTT temperature (∼45 °C). Notably, the combined therapy promotes migration of fibroblasts with no significant cytotoxicity as revealed through cell experiments in vitro. In bacteria-infected mice model, efficient bacterial ablation and wound healing are further demonstrated with negligible side effects in vivo. Overall, the rational design of a drug carrier with photothermal and therapeutic effects provides a novel intervention for amplifing wound disinfection clinically.

A Bioresorbable and Conductive Scaffold Integrating Silicon Membranes for Peripheral Nerve Regeneration

“…Advanced micro-and nanofabrication techniques enable the fabrication of Si into devices of diverse forms and sizes. As Si has been extensively explored for neural sensing, [45] opto-thermal applications, [46] and optoelectronic stimulation, [47] the integration of functional Si devices with scaffold materials can potentially enable multifunctional devices that can maximize therapeutic outcomes. Overall, this work promotes the development of bioresorbable and conductive neural interfaces to create biomimetic microenvironments that are beneficial for regenerative medicine.…”

Applications of nanomaterials as treatments and diagnostic biosensors in microbial infections

“…PSi has also been modified to obtain many other unique properties. Surface modification of PSi with polydopamine results in more functional groups on the surface of the material, giving it the ability to produce photothermal effects 117 …”

Self-Assembled Nanoflowers Realizes Synergistic Sterilization with Photothermal and Chemical Kinetics Therapy

“…Photothermal therapy (PTT), which involves the use of suitable photothermal agents to convert laser energy into heat, has been well developed due to its noninvasive, remotely controllable, tissue-penetrating specificities, and minimal side-effects. − For example, heavy-atom-structured hypoxia-responsive probes for precise photoacoustic imaging and cancer therapy have been developed . In addition, heptacyanine nanodiagnostics with catalase-like activity can be used for synergistic phototherapy of cancer .…”