Screening and evaluation of variables in the formation of antibody particles by spray drying

Ramezani, Vahid; Vatanara, Alireza; Najafabadi, Abdolhossein Rouholamini; Gilani, Kambiz; Meybodi, Mohsen Nabi

doi:10.1016/j.powtec.2012.07.038

Cited by 21 publications

(15 citation statements)

References 30 publications

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“…The generation of polymeric droplet and subsequent dehydration are performed in a chamber with hot air flow. The dried powders are transferred into a cyclone (Faghihi et al 2014;Nandiyanto and Okuyama 2011;Ramezani et al 2013). Yamamoto et al prepared insulinloaded PLGA nanocomposite particles for inhalation by the spray-fluidized bed granulation method (Yamamoto et al 2007).…”

Section: Spray Dryingmentioning

confidence: 99%

Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

Emami

Yazdi

2019

J. Pharm. Investig.

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Background Pulmonary route is an attractive target for both systemic and local drug delivery, with the advantages of a large surface area, rich blood supply, and absence of first-pass metabolism. Numerous polymeric micro/nanoparticles have been designed and studied for controlled and targeted drug delivery to the lung. Area covered Among the natural and synthetic polymers for polymeric particles, poly(lactic acid) (PLA) and poly(lacticco-glycolic acid) (PLGA) have been widely used for the delivery of anti-cancer agents, anti-inflammatory drugs, vaccines, peptides, and proteins because of their highly biocompatible and biodegradable properties. This review focuses on the characteristics of PLA/PLGA particles as carriers of drugs for efficient delivery to the lung. Furthermore, the manufacturing techniques of the polymeric particles, and their applications for inhalation therapy were discussed. Expert opinion Compared to other carriers including liposomes, PLA/PLGA particles present a high structural integrity providing enhanced stability, higher drug loading, and prolonged drug release. Adequately designed and engineered polymeric particles can contribute to a desirable pulmonary drug delivery characterized by a sustained drug release, prolonged drug action, reduction in the therapeutic dose, and improved patient compliance.

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Section: Spray Dryingmentioning

confidence: 99%

Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

Emami

Yazdi

2019

J. Pharm. Investig.

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“…Кроме того, в работах коллектива показана возможность нагружения микрочастиц антибактериальными и цитостатическими препаратами с длительной кинетикой оттока препаратов in vitro (до 30 сут) (Murueva et al, 2013). Доказана биологическая безопасность и лекарственная эффективность ПГА микрочастиц, несущих цитостатический препарат, в культуре опухолевых клеток и на животных с модельной карциномой Эрлиха (Шишацкая и др., 2012;Murueva et al, 2013 (Daugherty et al, 2006;Vehring, 2008;Ramezani et al, 2013 (Anchordoquy et al, 2000).…”

Section: конструирование микрочастицunclassified

“…Недостатком данного метода считался довольно низкий выход микрочастиц, который составлял порядка 20-50 % от исходной массы вещества (Labrude et al, 1989;Johnson, 1997 (Brandenberger, 2003;Shoyele et al, 2006). (Ramezani et al, 2013); сополимера молочной и гликолевой кислот (ПМГК) (Jensen et al, 2010); ПМГК с содержанием препаратов (Bege et al, 2013); гибридов ПМГК с соевым лецитином (Wang et al, 2012); микрофибриллированной целлюлозы (Kolakovic et al, 2012); низкомолекулярного хитозана (Mohajel et al, 2012). Однако при анализе со-…”

Section: конструирование микрочастицunclassified

Construction of Microparticles Based on Resorbable Polymers Bioplastotan Using Spray Drying Method

Ekaterina¹

2014

J. Sib. Fed. Univ., Biol.

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The possibility of using the spray drying method for the construction of poly-3-hydroxybutyrate (P3HB) based microparticles was studied. The dependence of characteristics of microparticles (yield, average diameter, zeta-potential) from processing parameters (temperature at the inlet of the system, the feed rate of polymer solution and concentration of the polymer solution) was found. It is shown that zeta potential of microparticles was influenced by concentration of the polymer solution, and the average diameter was determined by temperature of the inlet. Also, conditions of obtaining P3HB microparticles were optimized to minimize polymer loss (approximately 10 %).

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“…Various excipients, such as polyols (mannitol, trehalose, sucrose) (8,(11)(12)(13)(14) and amino acids (15-16) are utilized to improve protein stability and particle properties. In this regard, cyclodextrins, as a novel class of excipients, are used to improve thermal stability, permeability and solubility.…”

Section: Introductionmentioning

confidence: 99%

Application of cyclodextrins in antibody microparticles: potentials for antibody protection in spray drying

Ramezani

Vatanara

Seyedabadi

et al. 2017

Drug Development and Industrial Pharmacy

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Screening and evaluation of variables in the formation of antibody particles by spray drying

Cited by 21 publications

References 30 publications

Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

Construction of Microparticles Based on Resorbable Polymers Bioplastotan Using Spray Drying Method

Application of cyclodextrins in antibody microparticles: potentials for antibody protection in spray drying

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