Construction of Microparticles Based on Resorbable Polymers Bioplastotan Using Spray Drying Method

Ekaterina, I Shishatskaya

doi:10.17516/1997-1389-0087

J. Sib. Fed. Univ., Biol.

2014

DOI: 10.17516/1997-1389-0087

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Construction of Microparticles Based on Resorbable Polymers Bioplastotan Using Spray Drying Method

I Shishatskaya Ekaterina¹

Abstract: The possibility of using the spray drying method for the construction of poly-3-hydroxybutyrate (P3HB) based microparticles was studied. The dependence of characteristics of microparticles (yield, average diameter, zeta-potential) from processing parameters (temperature at the inlet of the system, the feed rate of polymer solution and concentration of the polymer solution) was found. It is shown that zeta potential of microparticles was influenced by concentration of the polymer solution, and the average diame… Show more

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Cited by 2 publications

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Novel spray-dried PHA microparticles for antitumor drug release

et al. 2017

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The production of poly-3-hydroxybutyrate and poly-3-hydroxybutyrate/polyethylene glycol-based microparticles, loaded with antitumor drugs Paclitaxel (PTX) and 5-Fluorouracil (5-FU) by spray-drying technique was investigated. The average diameter of microparticles was found to be 3.4 ± 0.5 µm and zeta potential was about-44 mV. The addition of surfactant (PEG) did not show any effect on the morphological characteristics of the particles. But the chemical structure of drug influenced on the properties. Microparticles had heterogeneous pores on the surface when the hydrophobic PTX was encapsulated. For 5-FU loading microparticles, were established that the addition of surfactant positively influenced on the properties of particles and led to the loading of drug directly into the matrix. This is confirmed by the results of electron microscopy and dynamics of drug release in vitro. As a whole, the release profiles of PTX and 5-FU from composite P3HB/PEG-microparticles were less than from P3HBmicroparticles. The results of the morphological evaluation of Hela cells demonstrated that the use of cytostatic drugs loaded in P3HB microparticles induces morphological changes associated with apoptosis (chromatin condensation, core fragmentation, margination of nucleus). Thus, the obtained results can serve as the basis for the development of new antitumor drugs of prolonged action, intended for various modes of administration.

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Novel spray-dried PHA microparticles for antitumor drug release

et al. 2017

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Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery

et al. 2018

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In this study, polymer-based microparticles are used to improve the therapeutic properties of ceftriaxone (CEF) and render them safer. Poly-3-hydroxybutyrate (P3HB) and poly-3-hydroxybutyrate/polyethylene glycol (P3HB-PEG)based microparticles were prepared by two methods: a double emulsification technique and spray-drying. The microparticles were characterized in terms of size and zeta potential, morphology, total drug loading and drug release. The microparticles had spherical shapes with diameters of a size range from 0.74 to 1.55 m (emulsification technique) and from 3.84 to 6.51 m (spray-drying); CEF encapsulation efficiency was around 63% and 49% for these methods respectively. The CEF release from microparticles obtained by spray-drying reached 100% after 150h, while for microparticles obtained by emulsification technique the total release of CEF did not exceed 34% after 312 h. The release profiles could be best explained by Zero order kinetics model, Higuchi and Korsmeyer-Peppas models, as the plots showed high linearity. Antibacterial activity of the microparticles was evaluated against gram-positive and gram-negative bacterial strains. In general, CEF encapsulation in polymeric microparticles preserves the therapeutic efficacy of the CEF and provides its prolonged effect.

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Construction of Microparticles Based on Resorbable Polymers Bioplastotan Using Spray Drying Method

Cited by 2 publications

References 13 publications

Novel spray-dried PHA microparticles for antitumor drug release

Novel spray-dried PHA microparticles for antitumor drug release

Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery

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