2019
DOI: 10.1007/s40005-019-00443-1
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Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

Abstract: Background Pulmonary route is an attractive target for both systemic and local drug delivery, with the advantages of a large surface area, rich blood supply, and absence of first-pass metabolism. Numerous polymeric micro/nanoparticles have been designed and studied for controlled and targeted drug delivery to the lung. Area covered Among the natural and synthetic polymers for polymeric particles, poly(lactic acid) (PLA) and poly(lacticco-glycolic acid) (PLGA) have been widely used for the delivery of anti-canc… Show more

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Cited by 84 publications
(49 citation statements)
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“…They present several advantages thanks to their properties, like biocompatibility, biodegradability and versatility of functionalization [ 12 ]. Also, PLA and PLGA NPs display a high structural integrity leading to highly stable drug delivery systems [ 13 , 14 ]. Their capacities to improve drug pharmacokinetics and bioavailability, by protecting drug against inactivation by enzymes, by targeting and penetrating biofilms or by favoring a sustained drug release while limiting side effects, make these systems an adapted strategy to treat biofilm infections [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…They present several advantages thanks to their properties, like biocompatibility, biodegradability and versatility of functionalization [ 12 ]. Also, PLA and PLGA NPs display a high structural integrity leading to highly stable drug delivery systems [ 13 , 14 ]. Their capacities to improve drug pharmacokinetics and bioavailability, by protecting drug against inactivation by enzymes, by targeting and penetrating biofilms or by favoring a sustained drug release while limiting side effects, make these systems an adapted strategy to treat biofilm infections [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…Pulmonary delivery of drugs exerts potential advantages compared to the oral or parenteral routes. The large surface area of the human lung with its rich blood supply provides ideal conditions for rapid drug absorption into the systemic circulation and ensures a fast onset of drug action [ 13 , 14 ]. In addition, targeted drug delivery to the lungs enhances the therapeutic ratio significantly by decreasing severe systemic side effects and increasing drug therapeutic efficacy [ 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…Biodegradable plastics are a promising replacement for conventional synthetic plastics. Poly(lactic acid) (PLA) is an attractive biopolymer for packaging engineering [ 1 ], biomedical fields [ 2 ], automobile engineering [ 3 , 4 ] and the electricity industry [ 5 ] because of its biodegradability, non-toxicity, high optical transparency and good mechanical, thermal and electrical properties [ 6 , 7 ]. However, PLA has some shortcomings such as high flammability and poor toughness, which can easily lead to fire accidents and limit its further applications.…”
Section: Introductionmentioning
confidence: 99%