Salivary Visfatin Concentrations in Patients With Chronic Periodontitis

Tabari, Zahra Alizadeh; Azadmehr, Abbas; Nohekhan, Ali; Naddafpour, Nima; Ghaedi, Fatemeh Baharak

doi:10.1902/jop.2013.130388

Cited by 37 publications

(38 citation statements)

References 31 publications

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“…Mohamed et al reported a positive correlation between PD and GCF visfatin levels (34). Visfatin levels were also increased in the saliva following periodontal inflammation (35,36). These findings support our results that visfatin levels correlated positively with the severity of periodontitis.…”

Section: Discussionsupporting

confidence: 91%

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

et al. 2016

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The purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group 1 comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzymelinked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels.

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Section: Discussionsupporting

confidence: 91%

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

et al. 2016

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“…Tabari et al [17] reported that the rise in the visfatin levels was associated with CAL, but not with the other periodontal parameters. However, this finding was limited to the patients with periodontitis.…”

Section: Discussionmentioning

confidence: 98%

“…In their study with 50 healthy individuals, Mamali et al [32] reported that visfatin is an adipokine which can be identified and measured in the saliva. Tabari et al [17] evaluated the salivary visfatin levels in healthy individuals and in patients with periodontal disease together with the clinical periodontal parameters. They also concluded that visfatin levels can be measured in saliva and the levels are higher in chronic periodontitis compared to those of the healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation

Özcan¹,

Saygun²,

Serdar

et al. 2014

Clin Oral Invest

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“…Patient was classified as having hyposalivation if the saliva quantity was below 5 mL at end of 20-minute period. 3 Periodontal examination was done by a single examiner expert in periodontia to eliminate inter-examiner variability. Periodontal examination was conducted with all aseptic measures.…”

Section: Inclusion and Exclusionmentioning

confidence: 99%

An Analytical Approach to Explore Clinico-Biochemical Relationship Between Type 2 Diabetes Mellitus (T2dm) and Oro-Dental Diseases Including Chronic Periodontitis

Deshmukh¹,

Sengupta²,

Goswami³

et al. 2016

jemds

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CONTEXTT2DM is associated with concomitant oral and dental manifestations that necessitate dental evaluation. AIMSThe aim of this study was to analyse oro-dental conditions particularly chronic periodontitis and their correlation with glycaemic status and with other complications in patients with T2DM. SETTINGS AND DESIGNComparative cross-sectional study. MATERIALS AND METHODSOne hundred subjects with T2DM were studied for oral manifestations and underwent comprehensive periodontal examination. RESULTSHyposalivation (58%) was the most common oral manifestation followed by periodontitis (50%), halitosis (45%), burning mouth sensation (25%), taste impairment (23%), stomatitis (18%), and oral candidiasis (8%) among 100 subjects with T2DM. T2DM patients with chronic periodontitis had significantly higher glycaemic indices including FPG, PPPG, HbA1C as compared to those without chronic periodontitis (p<0.05). T2DM patients with chronic periodontitis had more prevalent diabetes specific microvascular complications like neuropathy, diabetic kidney disease, retinopathy, as well as macrovascular disease as compared to those without chronic periodontitis. (p<0.05) There was statistically significant direct correlation between HbA1C and clinical attachment level and number of gingival sites with bleeding on probing. This association remained significant even after adjustment for serum creatinine, body mass index, plaque index, OHI-S. (r=0.29 p=0.048). CONCLUSIONSOur results suggest that glycaemic impairment is associated with increased severity of periodontitis. Also, periodontitis is associated with increased risk for diabetic complications. Further rigorous systematic studies with larger sample size are required to establish bidirectional relationship between chronic periodontitis and glycaemic status.

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Salivary Visfatin Concentrations in Patients With Chronic Periodontitis

Abstract: These results indicate that there is a relationship between salivary visfatin and CP; however, further studies are needed to confirm this finding.

Cited by 37 publications

References 31 publications

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation

An Analytical Approach to Explore Clinico-Biochemical Relationship Between Type 2 Diabetes Mellitus (T2dm) and Oro-Dental Diseases Including Chronic Periodontitis

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