Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation

Özcan, Erkan; Saygun, N; Serdar, Muhittin; Kurt, Nezahat

doi:10.1007/s00784-014-1308-0

Cited by 51 publications

(65 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In agreement with a recent report (13), chemerin was found in saliva from healthy donors, in the concentration of 1.3 ± 0.5 ng/mg total protein (mean ± SD, n = 15). Next, we determined chemerin RNA and protein levels in gingiva samples from patients suffering from periodontal inflammation.…”

Section: Resultssupporting

confidence: 93%

“…Previous studies reported significantly higher levels of chemerin in saliva from periodontitis patients compared with gingivitis patients and healthy controls (13), and in GCF samples from periodontitis patients compared with healthy controls (14). Although in our studies we did not directly compare chemerin levels in saliva or GCF samples within the same groups of patients, chemerin levels were similar in GCF samples from periodontitis and gingivitis patients, with a trend for highler levels in the periodontitis group (Table 2).…”

Section: Discussionmentioning

confidence: 94%

“…In common with other AMPs, chemerin in saliva or the GCF samples was found in less-than-effective concentrations to exert bactericidal effect on its own [Table 2; Figure 2; (13, 14, 24)]. Since chemerin levels at oral infection sites are likely to be higher than in CGF wash outs, local chemerin may be present in sufficient quantities to control oral microbiota by itself.…”

Section: Discussionmentioning

confidence: 99%

“…An internal 20-amino acid peptide V 66 –P 85 embodies most of the antimicrobial activity of active chemerin, and is comparable in potency to other antimicrobial peptides (AMPs) (9). Chemerin was recently reported to be present in the oral cavity, and the levels of chemerin in saliva and gingival crevicular fluid were increased in patients suffering from periodontitis (13, 14). Since periodontitis is associated with an imbalance of oral microbiota (15, 16), these findings together suggest that chemerin might influence disease processes through controlling bacteria burden and/or composition in the oral cavity and by regulating immune cell infiltration.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease

et al. 2017

View full text Add to dashboard Cite

Periodontal inflammation is one of the most common chronic inflammatory conditions in humans. Despite recent advances in identifying and characterizing oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors maintain a healthy homeostatic oral microbial community or prevent the development of a pathogenic oral microbiota remains poorly understood. An important determinant of microbiota fate is local antimicrobial proteins. Here, we report that chemoattractant protein chemerin, which we recently identified as a potent endogenous antimicrobial agent in body barriers such as the skin, is present in the oral cavity under homeostatic and inflammatory conditions. Chemerin and a chemerin-derived antimicrobial peptide are bactericidal against select bacteria strategically positioned in dental biofilm. Gingival crevicular samples from patients with gingivitis but not periodontitis contain abundant bioactive chemerin capable of inducing CMKLR1-dependent leukocyte migration. Gingipains secreted by the periodontopathogen P. gingivalis inactivate chemerin. Together, these data suggest that as an antimicrobial agent and leukocyte chemoattractant, chemerin likely contributes to antimicrobial immune defense in the oral cavity.

show abstract

Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Mohamed et al reported a positive correlation between PD and GCF visfatin levels (34). Visfatin levels were also increased in the saliva following periodontal inflammation (35,36). These findings support our results that visfatin levels correlated positively with the severity of periodontitis.…”

Section: Discussionsupporting

confidence: 90%

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

et al. 2016

View full text Add to dashboard Cite

The purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group 1 comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzymelinked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels.

show abstract

Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice

Ramos-Junior

Leite

Carmo-Silva

et al. 2016

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Chemerin is an adipokine that regulates adipogenesis and metabolic functions of mature adipocytes mainly through the activation of chemokine‐like receptor 1 (CMKLR1). Elevated levels of chemerin have been found in individuals with obesity, type 2 diabetes, and osteoporosis. This adipokine was identified as an inflammatory and metabolic syndrome marker. Considering that the association between metabolic syndrome and bone health remains unclear, the present study aimed to clarify the role of chemerin in the pathophysiology of bone loss induced by dyslipidemia, particularly modulating osteoclastogenesis. In vitro analyses showed a downregulation of CMKLR1 at the early stage of differentiation and a gradual increase at late stages. Strikingly, chemerin did not modify osteoclast differentiation markers or osteoclast formation; however, it increased the actin‐ring formation and bone resorption activity in mature osteoclasts. The increased bone resorption activity induced by chemerin was effectively inhibited by CMKLR1 antagonist (CCX832). Chemerin boosting mature osteoclast activity involves ERK5 phosphorylation. Moreover, two models of dyslipidemia (high‐fat diet [HFD]‐treated C57/BL6 and db/db mice) exhibited significantly increased level of chemerin in the serum and gingival tissue. Morphometric analysis showed that HFD‐treated and db/db mice exhibited increased alveolar bone loss compared to respective control mice, which was associated with an up‐regulation of chemerin, CMKLR1 and cathepsin K mRNA expression in the gingival tissue. The treatment of db/db mice with CCX832 effectively inhibited bone loss. Antagonism of chemerin receptor also inhibited the expression of cathepsin K in the gingival tissue. Our results show that chemerin not only increases osteoclasts activity in vitro, but also that increased level of chemerin in dyslipidemic mice plays a critical role in bone homeostasis. © 2016 American Society for Bone and Mineral Research.

show abstract

Evaluation of the salivary levels of visfatin, chemerin, and progranulin in periodontal inflammation

Abstract: Chemerin may be a novel biomarker in saliva to determine the severity of periodontal disease.

Cited by 51 publications

References 39 publications

Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease

Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice

Contact Info

Product

Resources

About