Salivary oxidative analysis and periodontal status in children with atopy

Abstract

Background and aimsPrevalence of atopic diseases is progressively increasing in children with unclear clinical picture in oral cavity. This study aimed to find correlation between the total antioxidant and periodontal status in the saliva of periodontally compromised with atopy.Materials and methodsThe groups consisted of patients of atopic diseases and gingivitis (ADG), of atopic diseases without gingivitis (AD), and healthy controls (HC). The level of gingival inflammation was evaluated using the sulcus bleeding index (SBI) reported by Mühlemann and Son. Glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) were estimated in saliva.ResultsThe mean salivary MDA levels of group HC was significantly lower compared with group ADG and AD (P < 0.05). Similarly, in the case of salivary GSH, marker levels revealed a significant decrease (P < 0.05) when mean values in the control group (5.12 ± 0.66 µmol/L) were compared with the ADG (2.31 ± 0.44 µmol/L) and AD groups (2.69 ± 0.56 µmol/L). The SOD activity was significantly lower in the ADG and AD groups compared with HC.DiscussionAs there was no significant difference in the level of SOD concentration between groups, we suggest that antioxidant imbalance is primarily explained by atopic disease.ConclusionThe results showed changes in antioxidant balance in children with atopy.

Clinical Assessment of the Hyperbaric Oxygen Therapy Efficacy in Mild to Moderate Periodontal Affections: A Simple Randomised Trial

“…Criteria of SBI scoring are: 0-healthy aspect of papilla and of marginal gingiva, without bleeding on probing; 1-healthy gingival aspect, but bleeding on probing; 2-bleeding on probing, modified colour, without edema; 3-bleeding on probing, modified colour, slight edema; 4-bleeding on probing, modified colour, evident edema; 5-spontaneous bleeding, modified colour, pronounced edema. SBI scoring is effectuated on the eight upper and lower anterior teeth, and four gingival areas are included for each tooth: mesial-labial, mesial-lingual, oro-mesial, oro-distal [31]. Index interpretation of BSI scores in this study was: excellent = 0; very good = 1; good = 2; satisfactory = 3; and unsatisfactory = 4.…”

The Impact of Oxidative Stress on Dental Implants

“…One of the main targets of free radicals are cell membrane polyunsaturated fatty acids in which free radicals promote lipid peroxidation [28], [27]. This process generates numerous sub-products, such as malondialdehyde (MDA), which is a highly toxic molecule that disrupts the cell membrane and leads to cell damage and an increase in OS.…”

Peculiarities of vascular endothelial growth factor of oral cavity in atopic condition VEGF of oral cavity in atopic condition

“…But generalized microcirculatory disturbance which is typical for atopic condition could be realized in periodontal injuries [8] and as result, periodontal problems are often observed in child age as consequences of different processes [9] and atopic conditions also [10,11]. As result, research of the pathogenesis of atopic changes becomes is goal for allergists, internists, pediatricians, pathologists other specialists that realized in clinical and experimental investigation [12][13][14] searching of new methods of diagnostics and estimation severity [15,16] which are directed for detection of pathogenetical links for creation of effective prophylactic and therapeutical measure.…”