Salivary Lysozyme in Relation to Dental Caries among Thai Preschoolers

Lertsirivorakul, Jinda; Petsongkram, Bongkoch; Chaiyarit, Ponlatham; Klaynongsruang, Sompong; Pitiphat, Waranuch

doi:10.17796/1053-4628-39.4.343

Cited by 13 publications

(15 citation statements)

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“…Chereda (2012) suggests that there is a misbalance between the microbial load and local immunity reflected in changes of biofilm followed by shifting of the hydrogen index to the acid side and increases demineralization of the hard dental tissues. The obtained data regarding the reduction of lysozyme activity in case of caries progression is confirmed by other sources and can be used in the diagnosis of this disease (Lertsirivorakul et al 2015;Lertsirivorakul et al 2015).…”

Section: Discussionsupporting

confidence: 67%

Correction of disordered oral immunity in children affected by dental caries with herbal immune modulator “Esberitox”

Cherepyuk¹,

Oktysyuk²,

Bazalytska³

et al. 2020

PHAR

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Dental caries is the most prevalent pathological condition in the child population of Ukraine. Despite the achievements of medical science, dental caries in children remains one of the most actual problems nowadays. Epidemiological investigations conducted in different regions of Ukraine demonstrate that 62% of children have decay and in many parts of the country the statistic is even higher up to 96.5% when the intensity of carious damage fluctuates between 3.2 to 7.2 teeth. This article reflects the results of the study regarding correction of disordered oral immunity indexes by immune modulator “Esberitox” in children affected by different caries activity. We have confirmed the high efficiency of the recommended scheme of caries prophylaxis that is proved by positive dynamic of oral immunological indexes observed 24 month after the beginning of the research. There was a certain rise of lysozyme by about 21.1% and s-IgA has increased by 28% in children from prophylactic groups in comparison with control groups.

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Section: Discussionsupporting

confidence: 67%

Correction of disordered oral immunity in children affected by dental caries with herbal immune modulator “Esberitox”

Cherepyuk¹,

Oktysyuk²,

Bazalytska³

et al. 2020

PHAR

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“…Similarly, Letsirivorakul et.al. [49] obtained similar results, unstimulated saliva sample taken from 32 caries-free children and 32 children with caries showed the concentration and lysozyme activity in children with caries were higher than in caries-free children (p = 0.008). Different results reported by Felizardo et.al [50] that found lysozyme unrelated to the caries experience.…”

Section: Advances In Health Science Research Volumesupporting

confidence: 62%

sIgA and Lisozim as Biomarker of Early Childhood Caries Risk

Octiara¹,

Sutadi²,

Siregar³

et al. 2018

Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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Abstract-Caries in children under 6 years old (Early Childhood Caries) is still a major oral health problems in many countries. The high prevalence of ECC should be prevented immediately based on the cause of caries. Saliva is one of the factors that play role in dental caries process, also play a role as caries prevention. This article describes the relationship between sIgA and salivary lysozyme to the incidence of ECC and the development of that protein as one of the caries biomarkers. Several studies reported that sIgA in caries-free children had higher concentrations than in ECC children. Lysozyme concentrations in unstimulated saliva are also significantly higher in the caries-free group compared with the ECC group. Determination of lysozyme and sIgA level in saliva may be helpful in diagnosing caries diseases and infections. It is concluded that the development of sIgA and salivary lysozyme can be used as one of the biomarkers for dental caries detection, risk assessment, diagnosis, prognosis and disease monitoring, and evaluation in ECC.

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“…Thanks to the biological activity of lysozyme, the formation of biofilms by cariogenic bacteria and the adhesion of Streptococcus mutans to hydroxyapatite are reduced [28]. According to the available literature, studies were conducted to determine whether there is a relationship between the level of lysozyme and the activity of caries [49,50]. Jentsch et al, in a study of adults followed for caries over a period of 4 years, observed that a lower caries increment was associated with lower levels of lysozyme [49].…”

Section: Discussionmentioning

confidence: 99%

Composition and Properties of Saliva in Patients with Osteoporosis Taking Antiresorptive Drugs

Sobczak

Kochańska

Drogoszewska

2023

IJERPH

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The aim of this study was to examine how the composition and properties of saliva change in people with osteoporosis who have received antiresorptive (AR) treatment, compared to patients with osteoporosis who have not yet received this treatment. Methods: The study population consisted of 38 patients with osteoporosis using AR drugs (Group I) and 16 patients with osteoporosis who had never used AR drugs (Group II). The control group consisted of 32 people without osteoporosis. Laboratory tests included determination of pH and concentrations of Ca, PO4, total protein, lactoferrin, lysozyme, sIgA, IgA, cortisol, neopterin, activity of amylase at rest, and stimulated saliva. The buffering capacity of stimulated saliva was also determined. Results: There were no statistically significant differences between the saliva of Group I and Group II. No statistically significant correlation was found between the amount of time using AR therapy (Group I) and the tested parameters of the saliva. Significant differences were found between Group I and the control group. The concentrations of PO4, lysozyme, and cortisol were higher, while concentrations of Ca ions, sIgA, and neopterin were lower, in comparison to the control group. The significant differences between Group II and the control group were smaller, and they concerned only the concentrations of lysozyme, cortisol, and neopterin. Conclusions: The saliva of people with osteoporosis subjected to AR therapy and those not subjected to AR therapy did not show statistically significant differences in terms of the examined parameters of the saliva. However, the saliva of patients with osteoporosis taking and not taking AR drugs was significantly different compared to the saliva of the control group.

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Salivary Lysozyme in Relation to Dental Caries among Thai Preschoolers

Abstract: The up-regulated expression of salivary lysozyme and the increased lysozyme activity in S-ECC preschoolers suggests a possible connection between salivary lysozyme and oral immunity in response to early childhood dental caries.

Cited by 13 publications

References 0 publications

Correction of disordered oral immunity in children affected by dental caries with herbal immune modulator “Esberitox”

Correction of disordered oral immunity in children affected by dental caries with herbal immune modulator “Esberitox”

sIgA and Lisozim as Biomarker of Early Childhood Caries Risk

Composition and Properties of Saliva in Patients with Osteoporosis Taking Antiresorptive Drugs

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