Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus

Yılmaz, Doğukan; Topçu, Ali; Akçay, Emine Ülkü; Altındiş, Mustafa; Gürsoy, Ulvi Kahraman

doi:10.1080/00016357.2020.1715471

Cited by 20 publications

(29 citation statements)

References 28 publications

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“…Like others, we found that several salivary biomolecules are differentially expressed in DWoP and DWP compared with periodontally healthier patients (Arreguin‐Cano et al, 2019; Costa et al, 2010; Gupta et al, 2016; Ribeiro et al, 2011; Yilmaz et al, 2020). The greatest differences between DWoP and NP in our study were observed with salivary concentrations of IL‐1β and MMP‐8.…”

Section: Discussionsupporting

confidence: 83%

Salivary biomarkers for discriminating periodontitis in the presence of diabetes

Miller

Ding

Dawson

et al. 2020

J Clinic Periodontology

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AimSalivary biomarkers can help in assessment of periodontitis; however, concentrations may be altered in the presence of diabetes. Hence, the ability of salivary biomarkers to discriminate periodontally healthy type II diabetics (T2DM) from T2DM who have periodontitis was examined.MethodsNinety‐two participants (29 with T2DM with chronic periodontitis, DWP; 32 T2DM without chronic periodontitis, DWoP; and 31 Not Periodontitis, NP) provided saliva and clinical parameters of periodontal health were recorded. Salivary concentrations of interleukin (IL)‐1β, IL‐6, matrix metalloproteinase‐8 (MMP‐8), macrophage inflammatory protein‐1α (MIP‐1α), adiponectin and resistin were measured by immunoassay.ResultsSalivary analyte concentrations for IL‐1β, MMP‐8 and resistin correlated with clinical parameters of periodontitis, with MMP‐8 demonstrating the strongest positive correlation with PD ≥5 mm (p < 0.0001). Periodontal health was reflected in salivary analyte concentrations by group, with concentrations of IL‐1β and MMP‐8 showing significant associations with periodontitis (p ≤ 0.04) that increased in concentration from health to DWoP to DWP. Odds ratio (OR) analyses showed that MMP‐8 discriminated periodontitis from NP (OR of 8.12; 95% CI: 1.01–65.33; p = 0.03) and in the presence of T2DM (DWP vs DWoP, OR = 5.09; 95% CI: 1.24–20.92; p = 0.03).ConclusionSalivary MMP‐8 and IL‐1β discriminate periodontitis in T2DM.

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Section: Discussionsupporting

confidence: 83%

Salivary biomarkers for discriminating periodontitis in the presence of diabetes

Miller

Ding

Dawson

et al. 2020

J Clinic Periodontology

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“…From a total of 12 studies, 10 were observational studies (6 cross-sectional [ 30 , 31 , 32 , 33 , 34 , 35 ] and four case-control [ 36 , 37 , 38 , 39 ]), 1 was an animal study [ 40 ], and 1 was an in vitro study [ 41 ]. Different fluids/tissues were used for the HDPs’ analysis, including GCF [ 30 , 31 , 34 , 36 , 37 , 38 ], saliva [ 33 , 35 , 39 ], GT [ 32 ], and human oral epithelial cells [ 41 ]. However, one study [ 40 ] used both blood and GT for the analysis.…”

Section: Resultsmentioning

confidence: 99%

“…However, one study [ 40 ] used both blood and GT for the analysis. Three studies investigated adrenomedullin [ 30 , 36 , 38 ], two studies investigated HBD 1 [ 33 , 34 ], and study each investigated hBD 1 and hBD 3 [ 31 ], hBD 2, hBD 3 and hCAP18/LL-37 [ 32 ], hBD 2 [ 35 ], hCAP18/LL-37 [ 37 ], hBD 1, hBD 2, hBD 3 and hCAP18/LL-37 [ 39 ], and hBD 3 [ 40 ] and lipocalin 2 [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…In one study, the healthy control group showed more increased levels of HDP than the DM2 group with PD [ 34 , 37 ]. Interestingly, one study showed greater levels of hCAP18/LL-37 and decreased hBD 1, hBD 2, and hBD 3 levels in DM2 with the PD group than the CP group [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…All the studies [ 36 , 37 , 38 , 39 ] evaluated by NOS for cross-sectional studies scored more than 7, suggesting high quality of the studies ( Figure 2 ). For studies assessed by the NOS modified for cross-sectional studies, 1 study [ 30 ] scored 9 points (very good study), 4 studies [ 31 , 32 , 33 , 34 ] scored 8 points (good studies), and 1 study [ 35 ] scored 6 points (satisfactory study) ( Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Host Defence Peptides in Diabetes Mellitus Type 2 Patients with Periodontal Disease. A Systematic Review

et al. 2021

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The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case-control, 6 cross-sectional, 1 animal, and 1 in vitro) fulfilled the selection criteria and were included. The majority of research found that HDPs were upregulated in DM2 patients with PD. Three investigations, however, found that HDPs were downregulated in DM2 patients with PD. HDPs play a part in the pathophysiology of PD and DM2. Nonetheless, more human, animal and laboratory investigations are needed to fully understand validation of the link, as the evidence is limited. Understanding HDPs as common moderators is critical, aimed at unlocking their potential as therapeutic and diagnostic agents.

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Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis

et al. 2022

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Salivary human beta-defensins and cathelicidin levels in relation to periodontitis and type 2 diabetes mellitus

Cited by 20 publications

References 28 publications

Salivary biomarkers for discriminating periodontitis in the presence of diabetes

Salivary biomarkers for discriminating periodontitis in the presence of diabetes

Host Defence Peptides in Diabetes Mellitus Type 2 Patients with Periodontal Disease. A Systematic Review

Salivary levels of hBDs in children and adolescents with type 1 diabetes mellitus and gingivitis

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