Salivary 8-hydroxyguanosine levels in smokers and non-smokers with chronic periodontitis

Varghese, Jothi; Bhat, Vinutha; Chianeh, Yousef Rezaei; Kamath, Vinayak; Husain, N Al Haj; Özcan, Mutlu

doi:10.1007/s10266-020-00496-x

Cited by 13 publications

(10 citation statements)

References 42 publications

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“…In the study by Wolfram et al (2006), the concentration of 8-epi-PGF2α in the NWS of smokers with periodontitis was significantly higher compared to non-smokers with periodontitis. Varghese et al (2020) showed higher levels of salivary 8-OhdG in the group of smokers with chronic periodontitis compared to non-smoking controls with periodontitis. Salivary 8-OhdG levels correlated with clinical indicators of periodontal disease (plaque index, gingival index, pocket probing depth and clinical attachment levels).…”

Section: Cigarette-born Reactive Oxygen Species/reactive Nitrogen Species and Periodontal Diseasesmentioning

confidence: 77%

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

2022

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Alcohol abuse as well as smoking cigarettes has been proven to negatively affect the oral environment. The aim of this work was to provide a systematic review of the literature on the influence of ethanol and cigarette smoking on oral redox homeostasis. A search was performed for scientific articles indexed in the PubMed, Medline and Web of Science databases. We identified 32,300 articles, of which 54 were used for the final review, including the results from 2000 to 2021. Among the publications used to write this article, n = 14 were related to the influence of alcohol consumption (clinical studies n = 6, experimental studies n = 8) and n = 40 were related to the influence of smoking (clinical studies n = 33, experimental studies n = 7) on oral redox homeostasis. The reviewed literature indicates that alcohol abusers and smokers are more likely to suffer from salivary gland dysfunction, as well as develop precancerous lesions due to DNA damage. Compared to alcohol abstainers and non-smokers, alcohol drinkers and smokers are also characterized by a deterioration in periodontal health measured by various indicators of periodontal status. In summary, alcohol abuse and smoking are associated with disrupted oral redox homeostasis, which may lead not only to tooth loss, but also contribute to various adverse effects related to mental health, digestive processes and chronic inflammation throughout the human body.

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Section: Cigarette-born Reactive Oxygen Species/reactive Nitrogen Species and Periodontal Diseasesmentioning

confidence: 77%

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

2022

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“…All of the clinical measures in the CP group improved by the follow-up interval at the third month. However, the salivary levels of 8-OHdG in the CP smoker category were still higher values than the CPns [40]. Haswell et al (2014) analyzed the biomarkers of biological effect (BOBE) and demonstrated the difference between smokers, nonsmokers, and ex-smokers.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical periodontal markers (PI, GI, PD, and CLI) were assessed at the start of the study. SRP was performed on patients with CPs (CP smokers) and CPns (CP nonsmokers) [ 40 ]. In a three-month follow-up period, all of the clinical measures and salivary collections were repeated.…”

Section: Discussionmentioning

confidence: 99%

Smoking a Dangerous Addiction: A Systematic Review on an Underrated Risk Factor for Oral Diseases

Ahmed

Arshad

Basheer

et al. 2021

IJERPH

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Despite growing knowledge of the adverse effects of cigarette smoking on general health, smoking is one of the most widely prevalent addictions around the world. Globally, about 1.1 billion smokers and over 8 million people die each year because of cigarette smoking. Smoking acts as a source for a variety of oral and systemic diseases. Various periodontal issues such as increased pocket depth, loss of alveolar bone, tooth mobility, oral lesions, ulcerations, halitosis, and stained teeth are more common among smokers. This systematic review was conducted according to the guidelines from PRISMA, and research articles were retrieved from the Web database sources on 31 May 2021. The quality of research articles was ensured by the type of evidence from combined schema incorporating as schema-13 evidence type description, Cochrane health promotion and public health field (CHPPHF), and the health gains notation framework-14 screening question for quality assessment of qualitative and quantitative studies. Smokers have been found to have bleeding on probing, periodontal pockets, and clinical attachment loss compared to nonsmokers. Oral and respiratory cancers are among the most lethal known diseases caused by cigarette smoking and other commonly occurring sequelae such as stained teeth, periodontal diseases, etc.

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“…Several epidemiological studies have reported that periodontitis is related to arteriosclerotic events, and this association has been suggested due to the increase in serum levels of proinflammatory and pro-oxidant markers in both diseases, such as TNFα, IL-1, IL-6, and CRP [26][27][28][29], fibrinogen [30], MDA [18,25], and 8-OHdG [13,31]. Recently, a study has even shown that periodontitis-especially severe-is independently associated with a considerable increase in platelet count due to an increase in the systemic inflammation, which could be a new potential link with cardiovascular disease [32].…”

Section: Discussionmentioning

confidence: 99%

Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages

Andreu¹,

Santos-del-Riego²,

Payri³

2021

Healthcare

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Background: Periodontitis has been associated to systemic diseases and this association could be due to an increase in circulating inflammatory and oxidative stress biomarkers in the periodontal disease. This study aimed to evaluate the relationship between inflammatory and pro-oxidant markers according to different stages of periodontitis. Methods: This cross-sectional study included 70 subjects who were divided into three groups according to periodontitis stage: stage II (n = 22), stage III (n = 30), and stage IV (n = 18). We evaluated periodontal parameters and levels of high-sensitivity C-reactive protein (hsCRP), fibrinogen, and malondialdehyde (MDA) in serum, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine. Results: Serum hsCRP and fibrinogen levels were associated with periodontitis severity, which were higher in stage IV than in stages III and II of periodontitis (p = 0.003 and p = 0.025, respectively). We observed a slight yet insignificant increase in MDA levels related to periodontitis severity. Probing depth and clinical attachment loss were associated with serum fibrinogen and hsCRP levels. However, there were no significant associations between periodontal variables and MDA and 8-OHdG levels. Conclusion: Our data support an association between periodontitis and systemic inflammation, which increases with periodontal disease severity. This indicates the importance of the early diagnosis and treatment of periodontal disease to avoid the development or worsening of systemic inflammatory diseases.

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Salivary 8-hydroxyguanosine levels in smokers and non-smokers with chronic periodontitis

Cited by 13 publications

References 42 publications

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

Smoking a Dangerous Addiction: A Systematic Review on an Underrated Risk Factor for Oral Diseases

Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages

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