Safety and toxicity concerns of graphene and its composites

Koyyada, Arun; Orsu, Prabhakar

doi:10.1016/bs.coac.2020.08.011

Cited by 6 publications

(4 citation statements)

References 115 publications

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“…Thus, the pre-treatment of the BMDMs with the ZnO-Ag-SWCNTs and ZnO-Au-SWCNTs nano-hybrids was inferred to cause the increase in NOX2 activity in response to enhanced ROS formation (a major mechanism of bacteria-killing clearance enhancement) 34 . Although other mechanisms, such as cell wall damage 35 and DNA/RNA destruction 36 , cannot be ruled out, they were not tested in the current study. Furthermore, bacteria trapping in aggregated nanomaterials (both ZnO-Ag and ZnO-Au nano-composites, as well as ZnO-Ag-SWCNTs and ZnO-Au-SWCNTs nano-hybrids), as well as cell wall damage caused by the sharp edges of the NPs, cannot be ruled out 37,38 .…”

Section: Nano-hybrids Increased the Phagocytosis Of Phrodo E Coli Bio...mentioning

confidence: 99%

Modification of SWCNTs with hybrid materials ZnO–Ag and ZnO–Au for enhancing bactericidal activity of phagocytic cells against Escherichia coli through NOX2 pathway

Rugaie

Jabir²,

Mohammed³

et al. 2022

Sci Rep

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Zinc oxide-silver (ZnO–Ag), and zinc oxide-gold (ZnO–Au) nano-composites were prepared through wet chemical process and laced into single-walled carbon nanotubes (SWCNTs) to yield ZnO–Ag-SWCNTs, and ZnO–Au-SWCNTs hybrids. These nano-composite-laced SWCNTs hybrids were characterized using Raman spectroscopic, X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analyses. The hybrids were evaluated for their effects on phagocytic cells and bactericidal activity against the gram-negative bacteria E. coli. Their phagocytic cell activities and intracellular killing actions were found to be significantly increased, as the ZnO–Ag-SWCNTs and ZnO–Au-SWCNTs nano-hybrids induced widespread clearance of Escherichia coli. An increase in the production of reactive oxygen species (ROS) also led to upregulated phagocytosis, which was determined mechanistically to involve the phagocyte NADPH oxidase (NOX2) pathway. The findings emphasized the roles of ZnO–Ag- and ZnO–Au-decorated SWCNTs in the prevention of bacterial infection by inhibiting biofilm formation, showing the potential to be utilized as catheter coatings in the clinic.

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Section: Nano-hybrids Increased the Phagocytosis Of Phrodo E Coli Bio...mentioning

confidence: 99%

Modification of SWCNTs with hybrid materials ZnO–Ag and ZnO–Au for enhancing bactericidal activity of phagocytic cells against Escherichia coli through NOX2 pathway

Rugaie

Jabir²,

Mohammed³

et al. 2022

Sci Rep

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“…General descriptions and example applications of nanomaterials for the detection of food spoilage, adulteration, and pathogens are well summarized in recent review articles. [388,389] Due to safety and cost concerns, several nanomaterials widely studied in biomedical fields, such as graphene [389,390] and gold nanoparticles, encounter regulation barriers when entering the food industry. Food-derived nanomaterials are promising candidates for developing cost-effective food contacting devices that circumvent these concerns.…”

Section: Nanomaterial-based Biosensorsmentioning

confidence: 99%

“…They are utilized as supporting media for biosensing or additives to fabricate composite materials with other biopolymer materials. [390,391] For example, bacterial nanocellulose (bottom-up approach) was used as a flexible substrate embedding gold nanorods for SERS analysis to detect E. coli. [392] Considering the safety, cost-benefit, and versatile applications with other materials, the demand for food-derived nanomaterials will keep increasing.…”

Section: Nanomaterial-based Biosensorsmentioning

confidence: 99%

Biomaterials Technology for AgroFood Resilience

Sun

Cao

Kim

et al. 2022

Adv Funct Materials

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This review article highlights recent advances in designing biomaterials to be interfaced with food and plants, with the goal of enhancing the resilience of the AgroFood infrastructure by boosting crop production, mitigating environmental impact, and reducing losses along the supply chain. Special attention is given to innovations in biomaterial-based approaches and platforms for 1) seed enhancement through encapsulation, preservation, and controlled release of payloads (e.g., plant growth-promoting microbes) to the seeds and their rhizosphere; 2) precision delivery of multi-scale payloads to targeted plant tissues, organelles, and vasculature; 3) edible food coatings that regulate gas exchanges and provide antimicrobial properties to extend the shelf life of perishable food; and 4) food spoilage detection based on different sensor/reporter systems. Within each domain, biomaterials design principles, emerging micro-/nanofabrication strategies, and the advantages and disadvantages of different delivery/preservation/sensing platforms are introduced and critically discussed. Views of future requirements, aims, and trends are also given based on the opportunities and challenges of applying biomaterials in the AgroFood system.

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“…Thus, the pretreatment of BMDMs with GNPs and GOFs was associated with increased NOX2 activity in response to improved ROS production, which is possibly one of the principal mechanisms leading to enhanced killing clearance of bacteria [61]. However, other mechanisms cannot be ruled out, since cell wall damage [62] and DNA/RNA destruction [63] was not monitored. In most probability, bacteria trappings in the aggregated GOFs and cell wall damage by the sharp edges of the GOFs pieces cannot be ruled out [64,65].…”

Section: Gnps and Gofs Induce Nox2 Function In Bmdmsmentioning

confidence: 99%

Gold Nanoparticles and Graphene Oxide Flakes Synergistic Partaking in Cytosolic Bactericidal Augmentation: Role of ROS and NOX2 Activity

et al. 2021

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Gold nanoparticles (GNPs) and graphene oxide flakes (GOFs) exerted significantly (p < 0.0001) supportive roles on the phagocytosis bioactivity of the immune cells of phagocytic nature against the Gram-positive and Gram-negative human pathogenic bacteria Staphylococcus aureus and Escherichia coli. Under experimental conditions, upon bacterial exposure, the combined GNPs and GOFs induced significant clearance of bacteria through phagosome maturation (p < 0.0001) from time-points of 6 to 30 min and production of reactive oxygen species (ROS, p < 0.0001) through the NADPH oxidase 2 (NOX2, p < 0.0001)-based feedback mechanism. The effects of the combined presence of GNPs and GOFs on phagocytosis (p < 0.0001) suggested a synergistic action underway, also achieved through elevated signal transduction activity in the bone-marrow-derived macrophages (BMDM, p < 0.0001). The current study demonstrated that GNPs’ and GOFs’ bactericidal assisting potentials could be considered an effective and alternative strategy for treating infections from both positive and negative bacterial strains.

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Safety and toxicity concerns of graphene and its composites

Cited by 6 publications

References 115 publications

Modification of SWCNTs with hybrid materials ZnO–Ag and ZnO–Au for enhancing bactericidal activity of phagocytic cells against Escherichia coli through NOX2 pathway

Modification of SWCNTs with hybrid materials ZnO–Ag and ZnO–Au for enhancing bactericidal activity of phagocytic cells against Escherichia coli through NOX2 pathway

Biomaterials Technology for AgroFood Resilience

Gold Nanoparticles and Graphene Oxide Flakes Synergistic Partaking in Cytosolic Bactericidal Augmentation: Role of ROS and NOX2 Activity

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