S100 proteins in oral squamous cell carcinoma

Raffat, Muhammad Arsalan; Hadi, Naila Irum; Hosein, Mervyn; Mirza, Sana; Ikram, Salma; Akram, Zohaib

doi:10.1016/j.cca.2018.02.013

Cited by 24 publications

(21 citation statements)

References 28 publications

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“…These effects result in increased inflammatory response in OSF (Pitiyage et al, 2011). In addition, overexpression of S100A7 is reported in numerous cancers including OSCC (Zhou et al, 2008, Kesting et al, 2009, Raffat et al, 2018). Research indicates that S100A7 directly binds with receptors of advanced glycated end products (RAGEs) which are involved in inflammatory processes.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of salivary S100A7 in oral submucous fibrosis

Raffat

Hadi

Hosein

et al. 2019

The Saudi Dental Journal

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AimTo investigate the expression of salivary S100A7 levels among patients with oral submucous fibrosis (OSF) and healthy controls.MethodA total number of 60 participants were included in the study (30 OSF cases and 30 healthy controls). Demographic data was collected using a structured baseline questionnaire. Salivary S100A7 levels were quantified using enzyme-linked immunosorbent assay. Data was analyzed using Student t-test. Pearson correlation test was used to evaluate correlation between S100A7 levels and independent variables such as frequency and duration of areca nut use, gutka use, and mouth opening.ResultsThe mean value of salivary S100A7 for OSF group was 0.275 ng/ml, whereas mean value of salivary S100A7 for healthy controls was 0.195 ng/ml. Student t-test indicated that there was statistically significantly higher levels of S100A7 in OSF group as compared to healthy controls (p < .001). When the clinical variables of individual groups were analysed, a significant negative correlation was found between salivary S100A7 and duration of areca nut (p = .009) and gutka chewing (p = .03), whereas a significant positive correlation was found for mouth opening (p = .04).ConclusionOSF presented higher levels of salivary S100A7 levels as compared with healthy individuals and may be used as surrogate measure to identify subjects at risk for OSF.

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Section: Discussionmentioning

confidence: 99%

Differential expression of salivary S100A7 in oral submucous fibrosis

Raffat

Hadi

Hosein

et al. 2019

The Saudi Dental Journal

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“…The expression of S100 proteins in oral squamous cell cancer (OSCC) remains controversial, as expression profiles vary from study to study, and further investigation is needed to identify reliable biomarkers among the S100 family members in this context [200]. Nevertheless, S100A14 seems to have tumour-suppressing properties in oral cancer, as overexpression of S100A14 in OSCC cell lines resulted in suppression of invasion, associated with the downregulation of MMP1 and MMP9, as well as decreased proliferation, correlating with upregulation of p21 and G 1 cell cycle arrest [201,202].…”

Section: S100 Proteins In Other Cancer Typesmentioning

confidence: 99%

Friend or Foe: S100 Proteins in Cancer

Allgöwer

Kretz

Karstedt

et al. 2020

Cancers

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S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis, proliferation, apoptosis, differentiation, and inflammation. Although the complex network of S100 signalling is by far not fully deciphered, several S100 family members could be linked to a variety of diseases, such as inflammatory disorders, neurological diseases, and also cancer. The research of the past decades revealed that S100 proteins play a crucial role in the development and progression of many cancer types, such as breast cancer, lung cancer, and melanoma. Hence, S100 family members have also been shown to be promising diagnostic markers and possible novel targets for therapy. However, the current knowledge of S100 proteins is limited and more attention to this unique group of proteins is needed. Therefore, this review article summarises S100 proteins and their relation in different cancer types, while also providing an overview of novel therapeutic strategies for targeting S100 proteins for cancer treatment.

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“…OSF demonstrates epithelial reduction and atrophy, inflammation in the juxta-epithelial section, absence of vascularization of the connective tissues, and weakened collagen activity, resulting in an increased inflammatory change (Pitiyage et al, 2011). S100A7 overexpression has been reported in several cancers, including OSCC (Zhou et al, 2008;Kesting et al, 2009;Raffat et al, 2018). Previous studies have shown that S100A7 binds directly to the advanced glycated end products receptors (RAGEs) and participate in proinflammation.…”

Section: Discussionmentioning

confidence: 99%