Rotavirus Vaccination: Cost‐Effectiveness and Impact on Child Mortality in Developing Countries

Atherly, Deborah; Dreibelbis, Robert; Parashar, Umesh D.; Levin, Carol; Wecker, John; Rheingans, Richard

doi:10.1086/605033

Cited by 74 publications

(76 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Gn pig-adapted (passage 23) HRV Wa G1P [8] strain (virHRV) was administered orally to Gn pigs at a dose of 10 6 fluorescent focus units (FFU) in 3 ml of minimum essential medium (MEM; Thermo Fisher Scientific, Waltham, MA, USA), immediately after oral administration of 3 ml of 100 mM sodium bicarbonate to reduce gastric acidity as described previously (14).…”

Section: Methodsmentioning

confidence: 99%

Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant

Fischer

Kandasamy

Paim

et al. 2017

Clin Vaccine Immunol

View full text Add to dashboard Cite

Malnutrition leads to increased morbidity and is evident in almost half of all deaths in children under the age of 5 years. Mortality due to rotavirus diarrhea is common in developing countries where malnutrition is prevalent; however, the relationship between malnutrition and rotavirus infection remains unclear. In this study, gnotobiotic pigs transplanted with the fecal microbiota of a healthy 2-monthold infant were fed protein-sufficient or -deficient diets and infected with virulent human rotavirus (HRV). After human rotavirus infection, protein-deficient pigs had decreased human rotavirus antibody titers and total IgA concentrations, systemic T helper (CD3 ϩ CD4 ϩ ) and cytotoxic T (CD3 ϩ CD8 ϩ ) lymphocyte frequencies, and serum tryptophan and angiotensin I-converting enzyme 2. Additionally, deficientdiet pigs had impaired tryptophan catabolism postinfection compared with sufficient-diet pigs. Tryptophan supplementation was tested as an intervention in additional groups of fecal microbiota-transplanted, rotavirus-infected, sufficientand deficient-diet pigs. Tryptophan supplementation increased the frequencies of regulatory (CD4 ϩ or CD8 ϩ CD25 ϩ FoxP3 ϩ ) T cells in pigs on both the sufficient and the deficient diets. These results suggest that a protein-deficient diet impairs activation of the adaptive immune response following HRV infection and alters tryptophan homeostasis.

show abstract

Section: Methodsmentioning

confidence: 99%

Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant

Fischer

Kandasamy

Paim

et al. 2017

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…Two primary rotavirus vaccines have been certified (RotaTeq, Merck & Co, and Rotarix, GSK Biologicals) in major countries of the world and are slated to be incorporated across the developing world (Ruiz-Palacios et al, 2006;Vesikari et al, 2006). The vaccination is usually administered to children under 1 year of age and typically costs from $1 to $7 per dose (Atherly et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

Quantification of Rotavirus Diarrheal Risk Due to Hydroclimatic Extremes Over South Asia: Prospects of Satellite‐Based Observations in Detecting Outbreaks

et al. 2018

View full text Add to dashboard Cite

Rotavirus is the most common cause of diarrheal disease among children under 5. Especially in South Asia, rotavirus remains the leading cause of mortality in children due to diarrhea. As climatic extremes and safe water availability significantly influence diarrheal disease impacts in human populations, hydroclimatic information can be a potential tool for disease preparedness. In this study, we conducted a multivariate temporal and spatial assessment of 34 climate indices calculated from ground and satellite Earth observations to examine the role of temperature and rainfall extremes on the seasonality of rotavirus transmission in Bangladesh. We extracted rainfall data from the Global Precipitation Measurement and temperature data from the Moderate Resolution Imaging Spectroradiometer sensors to validate the analyses and explore the potential of a satellite‐based seasonal forecasting model. Our analyses found that the number of rainy days and nighttime temperature range from 16°C to 21°C are particularly influential on the winter transmission cycle of rotavirus. The lower number of wet days with suitable cold temperatures for an extended time accelerates the onset and intensity of the outbreaks. Temporal analysis over Dhaka also suggested that water logging during monsoon precipitation influences rotavirus outbreaks during a summer transmission cycle. The proposed model shows lag components, which allowed us to forecast the disease outbreaks 1 to 2 months in advance. The satellite data‐driven forecasts also effectively captured the increased vulnerability of dry‐cold regions of the country, compared to the wet‐warm regions.

show abstract

“…Успешное применение ротавирусных вакцин в стра-нах Латинской Америки также позволило подсчитать потенциальную эффективность рутинной иммунизации, которая к 2025 г. позволит предупредить 141 случай амбулаторных посещений по поводу РВГЭ и сохранит более 16 000 детских жизней на каждую 1000 вакцини-рованных младенцев [72].…”

Section: вопросы современной педиатрииunclassified

Vaccination Against Rotavirus Infection: 10-Year Global Experience of Successful Use

Намазова-баранова¹,

Федосеенко²,

Вишнева³

et al. 2017

Vopr. sovr. pediatr.

View full text Add to dashboard Cite

show abstract

Rotavirus Vaccination: Cost‐Effectiveness and Impact on Child Mortality in Developing Countries

Abstract: Introduction of rotavirus vaccines into the world's poorest countries is very cost-effective and is projected to substantially reduce childhood mortality.

Cited by 74 publications

References 56 publications

Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant

Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant

Quantification of Rotavirus Diarrheal Risk Due to Hydroclimatic Extremes Over South Asia: Prospects of Satellite‐Based Observations in Detecting Outbreaks

Vaccination Against Rotavirus Infection: 10-Year Global Experience of Successful Use

Contact Info

Product

Resources

About