Rosacea is Associated with Thyroid Autoimmunity: A Case Control Study

Hayta, Sibel Berksoy; Güner, Rukiye Yasak; Çam, Selim; Akyol, Melih

doi:10.4183/aeb.2018.248

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…However, the levels of CRP, anti-microsomal antibody (anti-M), and prolactin were increased in rosacea patients. 19 Artantaş et al reported acne rosacea in 3.6% of 220 patients with thyroid disease 20 In the present study, the rate of hypothyroidism was significantly higher in the rosacea group (14.3%) than in the control group (11.3%), even in both genders separately. However, since serum thyroid autoantibodies were not evaluated in all participants, laboratorial data confirming autoimmune thyroid disease were not demonstrated.…”

Section: Discussionsupporting

confidence: 43%

Assessment of thyroid disorders in patients with rosacea: a large case-control study

Belli

Alataş

Polat³

et al. 2021

Anais Brasileiros de Dermatologia

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Background The frequency of autoimmune diseases and thyroid cancer has been increasingly reported in association with rosacea. However, studies investigating thyroid diseases in rosacea are scarce with conflicting results. Objective To investigate the relationship between thyroid disorders and rosacea. Methods A large case-control study on age- and gender-matched 2091 rosacea patients and 9572 controls was conducted. Rosacea patients using the rosacea-specific ICD codes were compiled from the hospital records. Additionally, all participants were evaluated in terms of the presence of hypothyroidism and hyperthyroidism. Conditional logistic regression analysis was used to compute case-control odds ratios (OR) with 95% confidence intervals. Results The analysis comprehended 2091 rosacea patients (1546 female, 545 male; mean 48.73 ± 14.53 years) and 9572 controls (7009 female, 2563 male; mean 48.73 ± 15.1 years). Whereas the rate of hypothyroidism was significantly higher in rosacea patients (OR = 1.3, 95% CI 1.13–1.49, p < 0.001), there was no significant difference in the rate of hyperthyroidism between the groups (OR = 1.12, 95% CI 0.81–1.53, p = 0.497). Stratification for gender revealed a significant association between hypothyroidism and rosacea in females (OR = 1.27, 95% CI 1.1–1.47, p = 0.002) and males (OR = 1.58, 95% CI 1.04–2.4, p = 0.032). The frequency of hypothyroidism in rosacea patients increased towards the age range of 40–49 and then decreased, parallel with the hypothyroidism frequency of the study population. Study limitations Different subtypes and severities of rosacea were not distinguished. Conclusions Hypothyroidism may be a comorbidity of rosacea and investigation for hypothyroidism may be appropriate when evaluating rosacea patients.

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Section: Discussionsupporting

confidence: 43%

Assessment of thyroid disorders in patients with rosacea: a large case-control study

Belli

Alataş

Polat³

et al. 2021

Anais Brasileiros de Dermatologia

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Rosacea and associated medical disorders

Paley

2023

Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery

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Investigation of thyroid blood tests and thyroid ultrasound findings of patients with rosacea

Gönülal

Teker

Öztürk

et al. 2020

Dermatologic Therapy

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We aimed to investigate the relationship between rosacea and thyroid diseases by analyzing thyroid blood tests and ultrasound findings of our patients recently diagnosed with rosacea. This study was designed as a prospective, single‐center study. Dermatological examination findings, lesion locations were recorded, and rosacea clinical scores were calculated for all study group patients. The control group consisted of completely healthy women presented to our hospital during the study period for check‐up purposes. Serum‐free thyroxine, free triiodothyronine, thyroid‐stimulating hormone, antithyroglobulin antibody, antithyroid peroxidase antibody levels were measured, and thyroid ultrasound examinations were performed for all study participants. The entire study cohort consisted of 123 patients (63 cases and 60 controls). There was no significant difference between the groups in terms of mean patient age (P < .05). Cheek was the most common lesion location (96.8%). There was no difference between the groups in terms of thyroid‐related laboratory parameters. However, anti‐TPO levels differed significantly with increasing disease severity (ie, RCSs). There were significant relationships between cheek lesions and fT4 (P = .021), while nose and chin lesions were associated with fT3 (P = .01, P = .001). Thyroid ultrasound findings revealed that rosacea patients tended to have larger thyroid nodules and more heterogeneous thyroid parenchymas than controls. Our findings indicate that thyroid blood tests, including thyroid autoantibodies, should be tested and thyroid ultrasounds should be performed in patients diagnosed with rosacea. However, these findings need to be validated by prospective studies conducted in larger patient series with more extended follow‐up periods.

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Rosacea is Associated with Thyroid Autoimmunity: A Case Control Study

Cited by 3 publications

References 27 publications

Assessment of thyroid disorders in patients with rosacea: a large case-control study

Assessment of thyroid disorders in patients with rosacea: a large case-control study

Rosacea and associated medical disorders

Investigation of thyroid blood tests and thyroid ultrasound findings of patients with rosacea

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