Root Extract of Purwoceng (Pimpinella pruatjan) Enhances Aggressiveness, but Not Libido, in Male Mice

Kanedi, Mohammad; Sutyarso,; Busman, Hendri; Nurcahyani, Nuning; Nurkhasanah, Wiwit

doi:10.9734/arrb/2017/36975

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…The ultrasound-assisted extraction (UAE) method yielded superior secondary metabolite extraction results than the NADES solvent with the maceration technique (Mansinhos et al, 2021). Therefore, UAE extraction procedures were performed for both methanol and NADES solvents (Kanedi et al, 2017;Ruesgas-Ramón et al, 2017;Vinatoru et al, 2017).…”

Section: Frontiers In Pharmacologymentioning

confidence: 99%

Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties

Syarifah

Suryadi²,

Hayun³

et al. 2023

Front. Pharmacol.

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Comfrey (Symphytum officinale L.) contains rosmarinic acid which has different pharmacological activities, such as antioxidant and anti-inflammatory activities. However, the medicinal use of comfrey is limited by the hepatotoxic effect of lycopsamine in comfrey, which overshadows the health benefits of rosmarinic acid. Natural deep eutectic solvents (NADES) have a wide range of extraction properties, that provides a new approach to the detoxification of comfrey. In the present study, betaine-based and choline chloride-based NADES were screened for selective extraction of rosmarinic acid over lycopsamine. Ultrasonication was used in conjunction with NADES extraction. The chemical profile of the NADES extracts on antioxidant, anti-inflammatory and hepatotoxic activities were investigated using some chemical reagents. Betaine-urea (1:2 molar ratio, 50% water) obtained the highest content of rosmarinic acid and a low level of lycopsamine (1.934 and 0.018 mg/g, respectively). Betaine-urea was also shown to be more effective to extract rosmarinic acid compared to methanol-UAE under the same conditions, which gave lower rosmarinic acid and higher lycopsamine levels (0.007 and 0.031 mg/g, respectively). Betaine-urea extracts showed higher antioxidant and anti-inflammatory properties as compared with other NADES extracts, however, had lower hepatotoxic profile. This study recommends the use of betaine-urea to detroxify comfrey to open wider opportunities for the development of comfrey for medicinal use.

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Section: Frontiers In Pharmacologymentioning

confidence: 99%

Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties

Syarifah

Suryadi²,

Hayun³

et al. 2023

Front. Pharmacol.

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“…zerumbet., mempunyai komponen utama 3-O-met.,hyl kaempferol yang memberikan aktivitas analgesik dan antiinflamasi yang berhubungan mengatasi nyeri haid (Zakaria et., al., 2010). Ekstrak akar P. pruatjan memberikan peningkatan agresifitas seksual pada mencit jantan (Kanedi et., al., 2017) yang dimungkinkan disebabkan oleh kandungan met.,abolit sekunder mayor dari tumbuhan tersebut yaitu (Z)-γ-bisabolene (Nurcahyanti et., al., 2016). Kravchenko et., al., (2019) mengungkapkan ekstrak rimpang Z. officinale yang mengandung gingerol, shogaol, dan capsaicin memberikan aktivitas analgesik tinggi yang berhubungan dengan penggunaannya untuk mengatasi keputihan, nyeri haid, dan nifas.…”

Section: Pengetahuan Tradisional Tumbuhan Obat Untuk Permasalahan Sek...unclassified

Pendekatan Etnobotani Tumbuhan Obat Untuk Permasalahan Seksual Suku Tengger Di Desa Argosari, Lumajang, Indonesia

Bhagawan

Barsyaif

Hidayat

2021

J. Tumbuhan Obat Indonesia

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ABSTRACT The people of Tengger in Argosari village receive their knowledge of traditional medicine from their ancestors. This traditional knowledge is inherited and subsequently preserved across generations. This ethnobotanical medicinal plant study began with the participation observatory method and interviewed 28 local Tenggerese people who were selected by purposive and snowball sampling. Ethnobotanical data were analyzed to understand the proportion of cited plants. The analysis was calculated to obtain species use-value (SUV), family use-value (FUV), and fidelity level (FL). We have inventoried 16 species of plants belonging to 9 families to treat five types of sexual problems. The result showed that Piper betle L. had the highest SUV (1.21). Zingiberaceae was recorded as the largest family (6 plant species) with high FUV (0.69). Rhizome (47,06%) and leaves (41.18%) are the most dominant parts used as ingredients in traditional medicine. The majority of Argosari villagers prepare medicinal plants by decoction techniques (94.12%), then use them orally (94.12%). Pimpinella pruatjan Molkenb. (purwoceng) that is used for aphrodisiac has the highest FL value (78.57%). So it has the potential to be developed related to its pharmacological effects and the content of its active secondary metabolites. Since P. pruatjan is categorized as rare and protected species, so it requires a policy on its use as raw material for traditional medicines. Keywords: Ethnobotany, Medicinal plants, Sexual problems, Tengger tribe, Argosari Village. ABSTRAK Masyarakat suku Tengger di desa Argosari mendapatkan ilmu pengobatan tradisional dari nenek moyang mereka. Pengetahuan tumbuhan obat ini diwariskan dan selanjutnya dilestarikan dari generasi ke generasi. Pendekatan etnobotani tumbuhan obat ini dimulai dengan metode participation observatory dan mewawancarai 28 masyarakat lokal suku Tengger yang diseleksi secara purposive dan snowball sampling. Analisis data etnobotani digunakan untuk memahami proposi tumbuhan yang tersitasi, yaitu: species use-value (SUV), family use-value (FUV), dan fidelity level (FL). Studi ini telah berhasil menginventarisasi 16 spesies tumbuhan yang termasuk dalam 9 famili untuk pengobatan 5 jenis penyakit permasalahan seksual. Sirih (Piper betle L.) memiliki SUV tertinggi yaitu 1,21, sedangkan Zingiberaceae terdata sebagai famili terbanyak (6 spesies tumbuhan) dengan FUV tertinggi (0,69). Rimpang (47,06%) dan daun (41,18%) merupakan bagian yang dominan digunakan sebagai bahan obat tradisional. Mayoritas masyarakat desa Argosari mempreparasi tumbuhan obat tersebut dengan tehnik dekokta (94,12%), selanjutnya menggunakannya secara oral (94,12%). Pimpinella pruatjan Molkenb. (purwoceng) yang berfungsi sebagai tumbuhan afrodisiak memiliki nilai FL tertinggi (78,57%), sehingga sangat berpotensi dikembangkan terkait efek farmakologis dan kandungan metabolit sekunder aktifnya. P. pruatjan termasuk dalam spesies langka dan dilindungi sehingga memerlukan kebijakan dalam pemanfaatannya sebagai bahan baku ramuan obat tradisional. Kata kunci: Etnobotani, Tumbuhan obat, Permasalahan seksual, Suku Tengger, Desa Argosari.

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“…This plant is often found in mountainous areas such as the Dieng Plateau and Mount Lawu in Central Java, Mount Pangrango and Mount Galunggung in West Java, as well as in the Tengger and Iyang Mountains in East Java. The plant has medicinal properties as an aphrodisiac, diuretic and tonic [5].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Purwoceng Extract on the Etawa Crossbreed Bucks Mating

Yahya,

Sitepu,

Negara

2024

AJRiZ

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Aims: This research aims to determine the effect of purwoceng extract on Etawa crossbreed bucks Study Design: Completely randomized non-factorial design with 4 treatments given to bucks (ethawa crossbreeds), namely Purwoceng (Pimpinella alpina KDS or Pimpinella pruatjan Molk.) extract Place and Duration of Study: Ikhsan Farm, Sei Glugur Village, Pancur Batu District, Indonesia, between December 2023 and March 2024. Methodology: The research was carried out by administering various doses of purwoceng extract to Etawa crossbreed bucks and then observing mating with Etawa crossbreed doe. The treatment given was administration of purwoceng extract in amounts P0 (0 mg), P1 (400 mg), P2 (800 mg), and P3 (1400 mg). The research parameters were the frequency of mounting does, the frequency of penetration, the number of doe mounted and the number of doe penetrated. Results: There was an increase in the values of all parameters. The lowest frequency of mounting doe is P0, namely 17 and the highest is P3, namely 32. The lowest frequency of penetration is P0, namely 12 and the highest is 20. The lowest number of doe mounted is P0 and P1, namely 5 and the highest is P3, namely 7. The lowest number of doe penetrations is P0 and P1 are 5 and the highest are P2 and P3, namely 6. Conclusion: The best treatment is the addition of 800 mg of purwoceng extract (P2), Because the highest number of penetrating doe has the same value between P2 and P3, it will be more efficient if the treatment used is P2.

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Root Extract of Purwoceng (Pimpinella pruatjan) Enhances Aggressiveness, but Not Libido, in Male Mice

Cited by 4 publications

References 6 publications

Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties

Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties

Pendekatan Etnobotani Tumbuhan Obat Untuk Permasalahan Seksual Suku Tengger Di Desa Argosari, Lumajang, Indonesia

The Effect of Purwoceng Extract on the Etawa Crossbreed Bucks Mating

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