Role of vitamin A in type 2 diabetes mellitus biology: Effects of intervention therapy in a deficient state

Iqbal, Saba; Naseem, Imrana

doi:10.1016/j.nut.2014.12.014

Cited by 51 publications

(43 citation statements)

References 53 publications

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“…Our finding is consistent with several studies which conducted among Type 2 diabetic patients [21,22]. There is link between diabetes and deficient of Vitamin A levels indicating Vitamin A supplementation may have a role in T2DM biology [23]. In general, antioxidant Vitamins A, C, and E are found decreased in diabetic subjects, possibly due to an increased need to control the excessive oxidative stress produced by abnormalities in glucose metabolism [24].…”

Section: Discussionsupporting

confidence: 91%

Correlation of Oxidative Stress Markers Malondialdehyde (Mda), Antioxidant Vitamins A, E, and C With Glycated Hemoglobin (Hba1c) Levels in Type 2 Diabetes Mellitus

Altoum

Osman

Babker

2018

Asian J Pharm Clin Res

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Objective: The purpose of this study was to understand the relationship between oxidative stress markers malondialdehyde (MDA), antioxidant Vitamins A, E, and C and the glycated hemoglobin levels with Type 2 diabetes mellitus. Methods:The current study is a cross-sectional study group, comprised no diabetic individuals (100 healthy) as control groups and diabetic patients (300) as cases groups, attending the Khartoum -Sudan for routine follow-up during 2013-2015. The data were collected with the help of structured questionnaire and direct interview to collect information. Blood specimens were collected from both groups, and plasma levels of MDA, serum zinc, antioxidant Vitamins (A, E, and C), and glycated hemoglobin (HbA1c) were determined. Odds ratio and the 95% confidence interval (95% CI) were calculated for the presence of mutation between cases and controls and analyzed by SPSS program, version 13. Results:The results of this study indicate a highly significant difference between the means of HbA1c% of the test group (n=300) and the control group (n=100). Mean ± SD: 7.5 ± 1.4 versus 4.9 ± 0.3, respectively (p=0.001). Significant positive correlation between HbA1c and MDA (p=0.003). Significant correlation between HbA1c% and plasma Vitamins A, E, and C of the test group, respectively (p=0.002), (p=0.0008), and (p=0.01).

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Section: Discussionsupporting

confidence: 91%

Correlation of Oxidative Stress Markers Malondialdehyde (Mda), Antioxidant Vitamins A, E, and C With Glycated Hemoglobin (Hba1c) Levels in Type 2 Diabetes Mellitus

Altoum

Osman

Babker

2018

Asian J Pharm Clin Res

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“…Some studies have also shown that Vitamin E can be a helpful addition to decreasing oxidative stress in Type 2 diabetes. This was confirmed by a previous study in which HbA1c and other proteins were reduced with each 600 or 1200 mg/day of Vitamin E for 2 months [21]. The previous studies have shown that Vitamin E is helpful in leading significantly reducing approximately 60% of plasma LDL oxidation in diabetic patients [18].…”

Section: Discussionsupporting

confidence: 68%

Antioxidant Effect of Vitamins Combined A, C, and E Dose on Type 2 Diabetic Patients

Omar¹,

Al-Arabi²,

Mehdi³

et al. 2019

Asian J Pharm Clin Res

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Objectives: This study is to investigate the effect of oral Vitamins combined (A, C, and E) with metformin on the levels of fasting blood sugar (FBS), postprandial blood sugar (PPBS), hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) in Type 2 diabetic patients. Methods: A total of 32 patients with Type 2 diabetes were divided randomly into A and B groups, i.e., 16 per each group. Group A received metformin only twice a day while Group B received one tablet of Antox and metformin twice a day for 3 months. FBS, PPBS, HbA1c, TC, TG, LDL, and HDL were measured before and after the dose, and the results were analyzed statistically. Results: A significant decreases in FBS, PPBS, HbA1c, TC, TG, and LDL whereas results showed increasing significance in HDL level that seen in the patients of Group B which received Antox and metformin compared to the group which received metformin only. In conclusion, the results indicate that daily consumption of supplementary vitamins with metformin leads to improving blood glucose and lipids in patients with Type 2 diabetes and reducing the risk of complications. Hence, the dose can be used combined Vitamins A, C, and E with metformin in the treatment of Type 2 diabetes by maintaining good glycemic control.

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“…Type 2 diabetes has a less-clear relation with serum retinol and carrier proteins, with some studies showing no change and others showing reductions in type 2 diabetes (172). …”

mentioning

confidence: 99%

Biomarkers of Nutrition for Development (BOND)—Vitamin A Review

Tanumihardjo

Russell

Stephensen

et al. 2016

The Journal of Nutrition

358

414

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The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-informed advice to anyone with an interest in the role of nutrition in health. The BOND program provides information with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect, which will be especially useful for readers who want to assess nutrient status. To accomplish this objective, expert panels are recruited to evaluate the literature and to draft comprehensive reports on the current state of the art with regard to specific nutrient biology and available biomarkers for assessing nutritional status at the individual and population levels. Phase I of the BOND project includes the evaluation of biomarkers for 6 nutrients: iodine, folate, zinc, iron, vitamin A, and vitamin B-12. This review of vitamin A is the current article in this series. Although the vitamin was discovered >100 y ago, vitamin A status assessment is not trivial. Serum retinol concentrations are under homeostatic control due in part to vitamin A’s use in the body for growth and cellular differentiation and because of its toxic properties at high concentrations. Furthermore, serum retinol concentrations are depressed during infection and inflammation because retinol-binding protein (RBP) is a negative acute-phase reactant, which makes status assessment challenging. Thus, this review describes the clinical and functional indicators related to eye health and biochemical biomarkers of vitamin A status (i.e., serum retinol, RBP, breast-milk retinol, dose-response tests, isotope dilution methodology, and serum retinyl esters). These biomarkers are then related to liver vitamin A concentrations, which are usually considered the gold standard for vitamin A status. With regard to biomarkers, future research questions and gaps in our current understanding as well as limitations of the methods are described.

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Role of vitamin A in type 2 diabetes mellitus biology: Effects of intervention therapy in a deficient state

Cited by 51 publications

References 53 publications

Correlation of Oxidative Stress Markers Malondialdehyde (Mda), Antioxidant Vitamins A, E, and C With Glycated Hemoglobin (Hba1c) Levels in Type 2 Diabetes Mellitus

Correlation of Oxidative Stress Markers Malondialdehyde (Mda), Antioxidant Vitamins A, E, and C With Glycated Hemoglobin (Hba1c) Levels in Type 2 Diabetes Mellitus

Antioxidant Effect of Vitamins Combined A, C, and E Dose on Type 2 Diabetic Patients

Biomarkers of Nutrition for Development (BOND)—Vitamin A Review

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