Role of Streptococcus Pneumoniae in the Structure of Bacterial Infections in the Children Hospitalized to Inpatient Hospitals in Moscow in 2011–2012 World News of Vaccination

Баранов, А. А.; Намазова-баранова, Л. С.; Маянский, Н. А.; Куличенко, Т. В.; Полунина, Т. А.; Лазарева, А. В.; Алябьева, Н М; Катосова, Л. К.; Ponomarenko, Olga; Колтунов, И. Е.; Ivanenko, A M; Дегтярёва, Е. А.; Кондратенко, Н. В.; Корсунский, А. А.; Константинов, К. В.; Тулупов, Д. А.; Лазарева, М. А.

doi:10.15690/pf.v10i5.816

Cited by 12 publications

(5 citation statements)

References 22 publications

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“…населения [3]. В структуре внебольничных пневмоний бактериальной природы наиболее частым возбудителем (от 20 до 80 % всех случаев) является Streptococcus pneumoniae [4][5][6]. По данным Всемирной организации здравоохранения (ВОЗ), заболеваемость только инвазивными формами пневмококковой инфекции ежегодно варьирует от 10 до 23 случаев на 100 тыс.…”

Section: оригинальные статьиunclassified

The Effect of Selective and Mass Immunization Against Pneumococcal Infection on the Morbidity and Mortality due to Community-Acquired Pneumonia in Children Under 5 Years of Age

Семериков¹,

Зубова²,

Софронова³

2019

Pediatr. farmakol.

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Background. It is required to perform estimation of epidemiological and cost efficacy (regarding morbidity rate) of mass routine vaccination against pneumococcal infection in Russian children and carried out earlier selective vaccination of children from high-risk groups on the basis of four-year experience. It is also important to estimate the rate of hospital admissions in this patient group, long-term and annual cycles, morbidity age and etiology structure, and mortality due to community-acquired pneumonia as one of the most common form of pneumococcal disease. The aim is to study the effect of selective and mass immunization against pneumococcal infection on the morbidity and mortality due to community-acquired pneumonia in children under 5 years of age. Methods. The analysis of communityacquired pneumonia morbidity (in 2003–2018) and mortality due to pneumonias (in 2003–2018) in children under the 14 years old in Perm was carried out. Serotypes of circulating pneumococcus, etiology of community-acquired pneumonias and immunization cost efficacy (direct expense on health care) were further studied. The analysis of study indexes was carried out following selective (vaccination of at-risk children in 2011–2014) and mass (vaccination of infants in 2015–2018) immunization strategies. Results. The morbidity rate of community-acquired pneumonias decreased by 4.0 times (from 267.0 to 66.7 for 1000) after performing selective vaccination (2011–2014) in at-risk children (frequently and chronically ill children). The morbidity rate of community-acquired pneumonias in non vaccinated children of the same group increased by 2.0 times (from 40.0 to 80.0 for 1000 non-vaccinated). The prophylactic efficacy index was 46.0. Whereby the antibacterial index among vaccinated frequently and chronically ill children was 0.11 on one child. This index has decreased by 2.6 times (from 0.11 to 0.04 on one child) in a year within the framework of prospective controlled randomized clinical study. The antibacterial index among non-vaccinated children of this group remained slightly the same: 0.09 and 0.12 respectively. During the selective vaccination the mortality rate among infants decreased by 2 times: long-term average index was 17.9 (2011–2014) against 35.2 (2003-2010) on 100 thousand children. Mass vaccination of infants against pneumococcal infection has reduced the incidence of community-acquired pneumonias among children under 2 years of age and has led to absence of multiple sites of pneumococcal infection in children’s organizations. It also has reduced the number of hospitalized children and achieved zero mortality due to pneumonias in infants by the third year of this immunization strategy implementation. The obtained results were achieved mainly due to circulation of 7 pneumococcal serotypes (6A, 6B, 9V, 14, 19A, 19F, 23F) in children under 5 years of age. The threshold level of vaccination against pneumococcal infection advancing morbidity and mortality due to pneumonias in children was specified. The strategy of mass vaccination of infants was cost-effective. Conclusion. The new data on epidemiological and cost efficacy of various immunization strategies against pneumococcal infection in children was obtained.

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Section: оригинальные статьиunclassified

The Effect of Selective and Mass Immunization Against Pneumococcal Infection on the Morbidity and Mortality due to Community-Acquired Pneumonia in Children Under 5 Years of Age

Семериков¹,

Зубова²,

Софронова³

2019

Pediatr. farmakol.

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“…Streptococcus pneumoniae и Haemophilus influenzae типа b (Hib) -наиболее частые возбудители как острых, так и хронических воспалительных заболева-ний легких [4,5]. Около 40% детей в возрасте до 5 лет являются носителями Hib.…”

Section: обоснование первичный серологический статус детей с бронхолunclassified

“…Более того, респираторные инфекции способствуют возник-новению обострений БЛД, определяя таким образом тяжесть течения и исход основного заболевания [3]. В связи с отсутствием этиопатогенетической терапии БЛД усилия ученых и клиницистов направлены на про-филактику обострений, в том числе на предупреждение респираторно значимых инфекций.Streptococcus pneumoniae и Haemophilus influenzae типа b (Hib) -наиболее частые возбудители как острых, так и хронических воспалительных заболева-ний легких [4,5]. Около 40% детей в возрасте до 5 лет являются носителями Hib.…”

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“…Заболевания, вызванные гемо-фильной инфекцией и пневмококком, имеют затяжной характер и склонны к хроническому течению, формируя необратимые морфологические изменения бронхоле-гочной системы [4]. У пациентов младшего возраста в пяти педиатрических стационарах г. Москвы в когорт-ном исследовании 2011-12гг в 24% случаев в назофа-ренгиальных мазках был выделен S. pneumoniae [5,6]. Инфицирование Hib ассоциировано не только с высокой частотой тяжелых заболеваний респираторного трак-та, но и летальностью у детей в возрасте до 2 лет [6].…”

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Primary Serological Status and Immunological Efficacy of Vaccination against Streptococcus Pneumoniae and Haemophilus Influenzae Type b in Children with Bronchopulmonary Dysplasia: a Cohort Study

et al. 2018

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Обоснование. Первичный серологический статус детей с бронхолегочной дисплазией (БЛД) в отношении респи-раторно значимых патогенов остается неизученным. При этом эффективность вакцинации детей с БЛД против Streptococcus pneumoniae и Haemophilus influenzae типа b (HibПервичный серологический статус и иммунологическая эффективность вакцинации против Streptococcus pneumoniae и Haemophilus influenzae типа b у детей с бронхолегочной дисплазией: когортное исследование ОБОСНОВАНИЕ По современным представлениям, дети с бронхоле-гочной дисплазией (БЛД) относятся к группе высокого риска по респираторным заболеваниям [1,2]. Более того, респираторные инфекции способствуют возник-новению обострений БЛД, определяя таким образом тяжесть течения и исход основного заболевания [3]. В связи с отсутствием этиопатогенетической терапии БЛД усилия ученых и клиницистов направлены на про-филактику обострений, в том числе на предупреждение респираторно значимых инфекций.Streptococcus pneumoniae и Haemophilus influenzae типа b (Hib) -наиболее частые возбудители как острых, так и хронических воспалительных заболева-ний легких [4,5]. Около 40% детей в возрасте до 5 лет являются носителями Hib. Среди детей с хронически-ми бронхолегочными заболеваниями Hib выделяется в монокультуре 41% пациентов, в ассоциации с S. pneumoniae -у 30% [4]. Заболевания, вызванные гемо-фильной инфекцией и пневмококком, имеют затяжной характер и склонны к хроническому течению, формируя необратимые морфологические изменения бронхоле-гочной системы [4]. У пациентов младшего возраста в пяти педиатрических стационарах г. Москвы в когорт-ном исследовании 2011-12гг в 24% случаев в назофа-ренгиальных мазках был выделен S. pneumoniae [5,6].

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“…населения. Самые незащищенные группы населения перед пневмококко вой инфекцией -это дети дошкольного возраста и по жилые люди [3]. Носительство пневмококка является важным этапом в развитии инфекционного процесса, протекаю щего в большинстве случаев бессимптомно.…”

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Nasopharyngeal carriage of Streptococcus pneumoniae in children from day-care centers in Smolensk

Zharkova

Кречикова

Chagaryan

et al. 2020

CMAC

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Objective. To investigate a nasopharyngeal carriage and serotypes of S. pneumoniae in children aged 3 to 6 years from day-care centers in Smolensk. Materials and Methods. A total of 245 isolates of S. pneumoniae from 1027 nasopharyngeal swabs from healthy children attending day-care centers was tested. Identification of S. pneumoniae was performed according morphological, cultural and antigenic characteristics (Slidex pneumo-Kit, bioMeriеux, France), susceptibility to optohin and bile. Extraction of S. pneumoniae DNA (338) from nasopharyngeal specimens and cultures was performed using nucleic acids extraction kit AmpliSens® DNA-sorb-В (Interlabservice, Russia). Molecular typing was performed using CDC-recommended PCR method with 22 pairs of primers. Results. Children without signs of infection diseases from 14 day-care centers were examined, whose parents have signed an informed consent. There were 245 (24.0%) isolates of S. pneumoniae from 1027 specimens of nasopharynx’s swabs. The partly vaccinated with PCV13 were children aged 3–4 years – 311 (30.3%), in 95 children were healthy carriage (38.2%) of S. pneumoniae. The majority of children under 4 years (716⁄69.7%) were non vaccinated, healthy carriage of S. pneumoniae were 216 (29.3%). The predominant serotypes of S. pneumoniae in partly vaccinated children were: 3 (9.8%), 6AB (17.9%), 19F (13.8%), 11AD (12.2%), 23F (5.3%), 19A (2%), 18ABCF (1.6%), 14 (2%), 9AV (1.2%), 6CD (0.8%). The coincidence of S. pneumoniae serotypes in vaccinated children and included in PCV13 were 54%. The most common serotypes of S. pneumoniae in non-vaccinated children were: 11AD (12.2%), 15A/F (2%), 23A (2%), 22AF (0.4%), 19A (1.3%), 33FA/37 (1.6%) and non-typeable serotypes (27.8%). Conclusions. The low coverage of pneumococcal vaccine in children under 6 years shows the initial process of its implementation in Health Care. We detect the reduction of vaccine serotypes in children with incomplete immunization (54%) and notable increase in non-typeable serotypes (27.8%) in nonvaccinated children.

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Role of Streptococcus Pneumoniae in the Structure of Bacterial Infections in the Children Hospitalized to Inpatient Hospitals in Moscow in 2011–2012 World News of Vaccination

Cited by 12 publications

References 22 publications

The Effect of Selective and Mass Immunization Against Pneumococcal Infection on the Morbidity and Mortality due to Community-Acquired Pneumonia in Children Under 5 Years of Age

The Effect of Selective and Mass Immunization Against Pneumococcal Infection on the Morbidity and Mortality due to Community-Acquired Pneumonia in Children Under 5 Years of Age

Primary Serological Status and Immunological Efficacy of Vaccination against Streptococcus Pneumoniae and Haemophilus Influenzae Type b in Children with Bronchopulmonary Dysplasia: a Cohort Study

Nasopharyngeal carriage of Streptococcus pneumoniae in children from day-care centers in Smolensk

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