Role of leutenising hormone LH and insulin resistance in polycystic ovarian syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most frequent endocrine disorder seen in pre-menopausal women, affecting 5-10% of this population. It is characterized by menstrual irregularities and clinical hyperandrogenism such as hirsutism, seborrhoea and acne. PCOS women have insulin resistance, which results in compensatory hyperinsulinemia. A number of findings suggest that hyperinsulinemia may play a central role in the development of hyperandrogenism. This study is under taken to measure insulin resistance and leutenising hormone (LH) in PCOS patients and to see the relationship of insulin resistance with leutenising hormone (LH).Methods: Case control study was done taking 60 women PCOS and 60 age matched healthy women as controls. In all the subjects, concentrations of fasting plasma glucose estimated using enzymatic methods in semiautoanalyser. Fasting serum insulin and leutenising hormone (LH) measured by CLIA using Lumax-CLIA microplate reader. HOMA IR was calculated from estimated parameters.Results: The concentration of fasting serum insulin,fasting plasma glucose,HOMA –IR and leutenising hormone(LH) in controls are 9.33±3.08 µIU/ml,94.38±10.36mg/dl,12.16±0.67and 4.67±1.94 mIU/ml respectively; in PCOS cases they are 24.50±10.03µIU/ml,114.20±30.38 mg/dl,7.29±4.08 and 15.75±7.51 mIU/ml respectively. The mean concentrations of all the parameters were significantly (p value<0.05) increased in women with polycystic ovarian syndrome when compared with healthy women.Conclusions: This study shows that 75% of pcos women were insulin resistant and HOMA IR shows a positive correlation (r value 0.48, p<0.05) with serum leutenising hormone(LH).

Omega-3 Ameliorates Effects of Letrozole-Induced Polycystic Ovary Syndrome in Adult Female Rats

“…This was evident in the present study by the increased serum TNFα in L group and this is compatible with other study of (35) . The IR is usually associated with hyperinsulinemia as a compensatory response as detected in the present study and by other study (36) . Hyperinsulinemia itself also appears to be a contributor to IR via downregulation of insulin receptors which acts as a kind of positive feedback, increasing the need for insulin (37) .…”

Pathophysiological changes in experimental polycystic ovary syndrome in female albino rats: Using either hemin or L‐arginine

“…The IR is usually associated with hyperinsulinemia as a compensatory response, as detected in the present study and by (Ambiger, Patil, Rekha, & Dhananjaya (). This hyperinsulinemia activates cytochrome p‐450‐c17α‐hydroxylase, the androgen synthesizing enzyme in ovarian theca cells, and decreases sex‐hormone‐binding globulin production by the liver (Yao et al, ).…”

Study the Extent of The Relationship Among Hormonal Disturbance, Vitamin D Deficiency and Age in Women with Polycystic Ovary Thi-Qar City, Southern Iraq

“…Hypothalamic dysfunction may be a primary or secondary cause of abnormal steroid feedback. In either case serum LH level, rises and increased levels are observed clinically in approximately 50% of PCOS women [19]. In roughly 60% of individuals with PCOS [20], the ratio between FSH and LH levels, which is ordinarily around 2 to 1, becomes reversed and occasionally even higher (2 or 3 to 1) as a result of this derangement [20], as shown in the current study.…”