Role of Histammase (Diamine Oxidase) in Disappearance of Plasma Histamine in Anaphylaxis and after Histamine Injection

Hahn, F.; Kretzschmar, R; Teschendorf, H. J.; Mitze, R.

doi:10.1159/000230374

Cited by 13 publications

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“…The sham operated animals died several days after operation by unspecific infections or were killed after 7 days. elicited by released histamine, the inactivation of which was blocked by an inhibition of diamine oxidase [44][45][46]. Histamine at present is the most effective vasoactive substrate of this enzyme and among other vasoactive substances [47,48] responsible for the circulatory break-down after mesenteric artery occlusion [49].…”

Section: Tablementioning

confidence: 99%

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

et al. 1975

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From all mammals investigated so far only in rabbits diamine oxidase could not be detected in any tissue except the gut. Thus this species was chosen for studying the physiological and pathophysiological function of this enzyme in the gastrointestinal tract. By gel filtration on Sephadex G 50 and G 200 the enzyme was purified 100-fold, separated from a soluble monoamine oxidase, and the properties of the two enzymes were determined. Diamine oxidase from rabbit small intestine deaminated putrecine (Km = 1.3 times 10(-4) M, pH-optimum 6.4-6.9) and histamine (Km = 8 times 10(-5) M, pH-optimum 7.5), but not serotonin, and was inhibited by aminoguanidine, but not by pargyline. Soluble monoamine oxidase from rabbit small intestine catabolized serotonin (Km = 1.8 times 10(-4) M, pH-optimum 8.8) but not putrescine and histamine, and was inhibited by pargyline, but not by aminoguanidine. Based on its properties in vitro intestinal diamine oxidase could inactivate the vasoactive biogenic amine histamine in vivo. To confirm this hypothesis, in rabbits the small intestine was damaged severely by inducing total intestinal ischemia, which occurs as mesenteric infarction also in human subjects and is accompanied by histamine release. Treatment with aminoguanidine and ischemia killed the animals 3-times faster than ischemia alone, which supported our hypothesis on a protective role of intestinal diamine oxidase against histamine.

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Section: Tablementioning

confidence: 99%

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

et al. 1975

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“…The blood withdrawal started after the maximum histamine release which oc curs within 1.5 min of challenge [15,19], was over. The withdrawn blood volume was always measurably higher than the blood residue left behind inside the liver.…”

Section: Resultsmentioning

confidence: 99%

Liver Histamine and Zinc in Guinea Pig Anaphylaxis

Hahn¹,

Jobke²

1974

Int Arch Allergy Immunol

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The anaphylactic histamine release from guinea pig liver under amino-guanidine protection was studied in vivo by injecting antigen into the portal vein. No significant decrease of liver histamine could be observed 2 min after antigen, whereas a significant, though small increase of plasma histamine in the liver blood occurred indicating a histamine release of 1.2% of total liver histamine. When histamine was injected into the portal vein of normal guinea pigs at a dosage about 1.75 times the amount of total liver histamine, 48.8% or even more was retained by the liver. Since, on the basis of our previous studies on heparin release, the liver mast cell disintegration must be considered greater than is suggested by the extent of histamine output, much of the histamine released from the mast cells is probably taken up by the liver cells and metabolized. Zinc which is assumed to link histamine to heparin, was not increased in the liver blood plasma upon challenge with antigen. The guinea pig liver possibly acts as a buffer organ preventing histamine overload of the blood during anaphylaxis. It serves this function by binding hepatic as well as extrahepatic histamine, and in addition, by the heparin-mediated release and activation of liver histaminase which acts both locally and systemically.

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“…The clearance of exogenous and endogenous histamine from the peritoneal cavity of rats proceeded at a considerably slower rate than the reported clearance from the circulation [7][8][9][10][11]. The half life averaged 20 minutes with a range from 16 to 24 minutes.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies report on the removal of histamine from the circulation Correspondence: Prof. Dr E. Kownatzki, UniversitaetsHautklinik, Hauptstrasse 7, D-7800 Freiburg/Germany. in various species; the half life in these reports ranged from 20 seconds to 2 minutes [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Clearance of histamine from the peritoneal cavity of rats

Kownatzki

1984

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To study the clearance of histamine from the peritoneal cavity of rats, histamine was either injected i.p. or released locally by the injection of compound 48/80. At various intervals peritoneal fluid was removed and analysed for histamine concentration by a fluorometric assay. Exogenous and endogenous histamine were cleared from the peritoneal cavity at the same rate with a half life of 20 minutes. The rate was not altered by different histamine concentrations, by injection of heparin, and by the removal of peritoneal leukocytes. Repeated injections of large amounts of histamine resulted in a decreased clearance. The results suggest that histamine concentrations above the physiological level are quickly degraded. Activities of histamine as an inflammatory mediator are likely to be of short duration.

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Role of Histammase (Diamine Oxidase) in Disappearance of Plasma Histamine in Anaphylaxis and after Histamine Injection

Cited by 13 publications

References 0 publications

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

Diamine oxydase in rabbit small intestine: Separation from a soluble monoamine oxidase, properties and pathophysiological significance in intestinal ischemia

Liver Histamine and Zinc in Guinea Pig Anaphylaxis

Clearance of histamine from the peritoneal cavity of rats

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