Abstract:The anaphylactic histamine release from guinea pig liver under amino-guanidine protection was studied in vivo by injecting antigen into the portal vein. No significant decrease of liver histamine could be observed 2 min after antigen, whereas a significant, though small increase of plasma histamine in the liver blood occurred indicating a histamine release of 1.2% of total liver histamine. When histamine was injected into the portal vein of normal guinea pigs at a dosage about 1.75 times the amount of total li… Show more
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