Role of Corticosteroids in reducing Postoperative Swelling, Pain, and Trismus following Surgical Extraction of Impacted Mandibular Third Molars

Raakesh, Nambidiveetil; Veeraraghavan, Ravi; Puthalath, Ushass; Painatt, Jaeson Mohanan; Kumar, Manoj; Sasikumar, Prem; Subhash, Anil K; Navya, Purushothaman

doi:10.5005/jp-journals-10051-0112

Cited by 4 publications

(16 citation statements)

References 8 publications

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“…Reaksi radang ini lebih besar jika jumlah gigi yang dicabut semakin banyak dengan derajat nyeri sedang sampai berat. [2][3][4] Penggunaan adjuvan analgesia dapat meningkatkan derajat analgesia ketika diberikan bersamaan dengan analgesia yang lain sehingga mengurangi kebutuhan opiod pascaoperasi dan mempercepat masa pemulihan. Salah satu adjuvan yang sering diberikan adalah deksametason.…”

Section: Pendahuluanunclassified

“…Deksametason merupakan kortikosteroid dengan efek anti-inflamasi yang adekuat yang memiliki pengaruh menghambat proses nyeri. [2][3][4][5][6][7][8][9][10][11][12] Penggunaan deksametason sebagai adjuvan analgesia pascaoperasi odontektomi di luar negeri telah menjadi salah satu pilihan. Dosis deksametason sebagai adjuvan pascaoperasi dipergunakan dalam penelitian berkisar 0,11-0,21 mg/kgBB.…”

Section: Pendahuluanunclassified

“…Dosis deksametason sebagai adjuvan pascaoperasi dipergunakan dalam penelitian berkisar 0,11-0,21 mg/kgBB. [2][3][4][5][6][7][8][9][10][11][12] Tujuan penelitian ini adalah mengetahui efek pemberian deksametason sebagai adjuvan analgesia pada waktu kejadian nyeri pertama kali dengan NRS >3 pada pasien pascaoperasi odontektomi.…”

Section: Pendahuluanunclassified

“…Derajat nyeri pascaoperasi dipengaruhi oleh beberapa faktor di antaranya adalah usia, berat badan, BMI, dan lama operasi. 3,13 Respons nyeri pada usia muda lebih tinggi dibanding dengan usia tua karena pada usia muda lebih cepat mengekspresikan nyeri dibanding dengan orang tua yang lebih menerima respons terhadap nyeri dan kecenderungan untuk tidak melaporkan nyeri yang dirasakan. Keluhan nyeri juga semakin besar sesuai dengan peningkatan berat badan dan BMI.…”

Section: Pembahasanunclassified

“…Faktor lama operasi juga memengaruhi derajat nyeri pascaoperasi karena meningkatkan pelepasan mediator proinflamasi. 3,13,14 Penelitian ini melakukan pengukuran derajat nyeri dengan menggunakan numerical rating scale (NRS) yang dilakukan pada saat pertama kali pasien merasakan nyeri dengan NRS >3. Waktu Pertama kali pasien merasa nyeri dengan NRS >3 pada kelompok D lebih lama dibanding dengan kelompok K. Pada kelompok D rerata waktu pertama kali pasien merasa nyeri adalah pada jam ke-3 dan jam ke-4, sedangkan rerata waktu pertama kali pasien merasa nyeri pada kelompok K adalah pada jam ke-1 dan jam ke-2.…”

Section: Pembahasanunclassified

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Pengaruh Deksametason 0,2 mg/KgBB Sebagai Adjuvan Analgesia terhadap Waktu Kejadian Nyeri Pascaoperasi Odontektomi dengan Nrs >3

Alves

Suwarman²,

Kestriani³

2019

jap

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Deksametason merupakan kortikosteroid golongan glukokortikoid yang memiliki efek anti inflamasi yang adekuat. Penelitian ini bertujuan menilai waktu nyeri pertama kali dengan NRS >3 pada pasien pascaoperasi odontektomi. Penelitian ini merupakan uji acak terkontrol buta ganda pada 30 pasien dengan status fisik American Society of Anesthesiologist kelas 1 (ASA I) yang menjalani operasi odontektomi dalam anestesi umum di Rumah Sakit Dr. Hasan Sadikin Bandung periode Agustus-September 2019. Pasien dibagi menjadi dua kelompok, yaitu 15 pasien yang menerima deksametason (D) dan 15 pasien plasebo (K). Penilaian skala nyeri menggunakan nilai numeric rating scale pada NRS >3 pertama kali. Analisis statistika data hasil penelitian menggunakan chi square dan Mann-Whitney. Hasil penelitian menunjukkan waktu pertama kali terjadi nyeri dengan NRS >3 lebih lama pada kelompok D dibanding dengan kelompok plasebo dengan perbedaan bermakna (p<0,05). Simpulan penelitian ini adalah pemberian deksametason 0,2 mg/kgBB sebagai adjuvan analgesia terhadap waktu kejadian nyeri dengan NRS >3 pada pasien pascaoperasi odontektomi menghasilkan waktu yang lebih lama.

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Section: Pendahuluanunclassified

Section: Pembahasanunclassified

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Pengaruh Deksametason 0,2 mg/KgBB Sebagai Adjuvan Analgesia terhadap Waktu Kejadian Nyeri Pascaoperasi Odontektomi dengan Nrs >3

Alves

Suwarman²,

Kestriani³

2019

jap

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A novel therapeutic approach for reducing postoperative inflammatory complications after impacted mandibular third molar removal

et al. 2022

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Background: This study was designed to compare effect of combined use of dexamethasone and honey versus each agent alone in controlling complications associated with removal of impacted mandibular third molar. Methods: This randomized clinical study included patients suffering from impacted mandibular wisdom teeth. Patients were divided randomly into 4 groups. Group I, control, group II, received dexamethasone injection preoperatively, group III, received honey locally in the wound after extraction, and group IV, received dexamethasone injection preoperatively and topical honey application. All patients were evaluated preoperatively and postoperatively to assess facial edema, interincisal distance, pain, and total analgesic dose used. Results: Significant edema developed in group I than other groups and improved significantly in group II and III on seventh postoperative day, and tenth postoperative day in group I. Insignificant edema developed in group IV. Significant decrease in interincisal distance occurred in all groups on third postoperative day that improved significantly on seventh postoperative days in all groups except group I, it improved on tenth postoperative day. Pain was significantly minimum in group IV than other groups and its maximum degree was in group I. Conclusion: Both dexamethasone and honey are an effective way of minimizing swelling, pain, and trismus after removal of impacted lower third molars. Both agents either alone or in combination provide simple, safe, painless, and cost-effective method to eliminate postoperative discomfort. However, dexamethasone or honey can decrease complications related to surgical extraction of mandibular third molar, the simultaneous application of both agents is more effective method in this regard.

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Methylprednisolone and Hyaluronic Acid versus Each Agent Alone to Control Complication of Impacted Wisdom Removal

Altaweel

Gaber

Alnaffar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. Extraction of impacted molars is commonest operation in oral cavity and associated with complications disturbing patient’s quality of life. Hyaluronic acid is a nontoxic agent recommended for wound management due to its anti-inflammatory effects. Also, methylprednisolone sodium is used to reduce pain and edema. The aim this study was to compare the effect of combined use of corticosteroid and hyaluronic acid versus each agent alone in controlling postextraction complications of impacted mandibular third molars. Materials and Methods. This prospective randomized trial included patients suffering from impacted mandibular third molar. Patients were divided into four groups. Group I, control, and group II received methylprednisolone sodium succinate injection preoperatively, group III received hyaluronic acid applied in extraction socket, and group IV received preoperative methylprednisolone sodium succinate injection and topical hyaluronic acid in the socket. All patients were evaluated preoperatively and postoperative day to assess swelling, pain, mouth opening, and total analgesic dose. Results. Group IV showed insignificant edema along the study period, and other groups showed significant edema on third postoperative day that improved on seventh postoperative in group II and III and tenth postoperative day in group I. Significant decreased mouth opening occurred on second postoperative day in group I, while in other groups, it occurred in third postoperative day. Significant improvement occurred on seventh postoperative day in all groups except in group I which occurred on tenth postoperative day. There was less pain and analgesic dose reported in group IV than other groups. Conclusion. Combined use of methylprednisolone sodium succinate and hyaluronic acid significantly decrease postoperative complications than using each agent alone.

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Role of Corticosteroids in reducing Postoperative Swelling, Pain, and Trismus following Surgical Extraction of Impacted Mandibular Third Molars

Cited by 4 publications

References 8 publications

Pengaruh Deksametason 0,2 mg/KgBB Sebagai Adjuvan Analgesia terhadap Waktu Kejadian Nyeri Pascaoperasi Odontektomi dengan Nrs >3

Pengaruh Deksametason 0,2 mg/KgBB Sebagai Adjuvan Analgesia terhadap Waktu Kejadian Nyeri Pascaoperasi Odontektomi dengan Nrs >3

A novel therapeutic approach for reducing postoperative inflammatory complications after impacted mandibular third molar removal

Methylprednisolone and Hyaluronic Acid versus Each Agent Alone to Control Complication of Impacted Wisdom Removal

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