A novel therapeutic approach for reducing postoperative inflammatory complications after impacted mandibular third molar removal

Abstract

Background: This study was designed to compare effect of combined use of dexamethasone and honey versus each agent alone in controlling complications associated with removal of impacted mandibular third molar. Methods: This randomized clinical study included patients suffering from impacted mandibular wisdom teeth. Patients were divided randomly into 4 groups. Group I, control, group II, received dexamethasone injection preoperatively, group III, received honey locally in the wound after extraction, and group IV, received dexamethasone injection preoperatively and topical honey application. All patients were evaluated preoperatively and postoperatively to assess facial edema, interincisal distance, pain, and total analgesic dose used. Results: Significant edema developed in group I than other groups and improved significantly in group II and III on seventh postoperative day, and tenth postoperative day in group I. Insignificant edema developed in group IV. Significant decrease in interincisal distance occurred in all groups on third postoperative day that improved significantly on seventh postoperative days in all groups except group I, it improved on tenth postoperative day. Pain was significantly minimum in group IV than other groups and its maximum degree was in group I. Conclusion: Both dexamethasone and honey are an effective way of minimizing swelling, pain, and trismus after removal of impacted lower third molars. Both agents either alone or in combination provide simple, safe, painless, and cost-effective method to eliminate postoperative discomfort. However, dexamethasone or honey can decrease complications related to surgical extraction of mandibular third molar, the simultaneous application of both agents is more effective method in this regard.

Geographical Origin Authentication—A Mandatory Step in the Efficient Involvement of Honey in Medical Treatment

“…This distribution is shown in Figure 3. For this classification, 156 studies were taken into consideration, including wound treatment (33 studies) , metabolic disorders (33 studies) , oncology (17 studies) [108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124], respiratory conditions (13 studies) [125][126][127][128][129][130][131][132][133][134][135][136][137], oral health (14 studies) [138][139][140][141][142][143][144][145][146][147][148][149][150][151], surgery (11 studies) [152][153][154]…”

Cyanoacrylate versus suture as flap closure methods in mandibular third molar surgery: a split-mouth randomized controlled clinical study

“…M3M surgery is invariably related with post-operative complications, including pain, swelling and trismus ( 1 ). Therefore, numerous studies ( 15 - 17 ) have been carried out in an attempt to improve the post-operative outcomes of this procedure, including the method of flap closure, which remains a challenge ( 6 - 8 , 18 - 21 ).…”

“…Mandibular third molar (M3M) surgery is the most frequent surgical procedure performed by oral and maxillofacial surgeons. Its most prevalent post-operative complications include pain, swelling, trismus and, to a lesser extent, alveolar osteitis ( 1 ).…”