Role of citicoline in improvement of cognition, memory and post stroke disability in stroke patients

Abstract

Background: Citicoline has emerged as a potential neuroprotectant in experimental models in stroke patients. Citicoline has shown some beneficial effects in human ischaemic stroke and with an excellent safety profile while in haemorrhagic stroke data is limited. Authors conducted this study to test role of citicoline in stroke patients in terms of cognition, memory and post stroke disability.Methods: In this prospective study, patients had to be previously independent, aged >18 years of age, presented within 24 hours of onset of symptoms of stroke diagnosed by neuroimaging (CT or MRI). Patients received either a placebo or 500 mg/12 h citicoline for 12 weeks (orally or intravenously). The primary aim was to evaluate improvement in cognition, memory and post stroke disability after 12 weeks. The efficacy endpoint was the percentage of subjects with MMSE and DRS at 12 weeks.Results: Total 75 stroke patients were enrolled, 40 in control group and 35 in citicoline group were allotted randomly. Patients in citicoline group were given intravenous citicoline 500 mg/12 hour during hospital stay and orally 500 mg/12 hour after discharge for up to 12 weeks. Control Group was given Placebo. cognition, memory and post stroke disability show positive improvement in citicoline group.Conclusions: Citicoline shows beneficial effects in stroke in terms of cognition, memory and post stroke disability.

Citicolina: revisión farmacológica y clínica, actualización 2022

“…Szelenberger et al [ 594 ] postulate citicoline among the pharmacological interventions for enhancing brain self-repair and stroke recovery. Singh et al [ 595 ] did a prospective study to test the role of citicoline in stroke patients in terms of cognition, memory and post stroke disability. Patients received either a placebo ( n = 40) or 500 mg/12 hours citicoline ( n = 35) for 12 weeks (orally or intravenously).…”

“…Szelenberger et al [ 594 ] postulan la citicolina entre las intervenciones farmacológicas para mejorar la autorreparación del cerebro y la recuperación del accidente cerebrovascular. Singh et al [ 595 ] realizaron un estudio prospectivo para probar el papel de la citicolina en pacientes con accidente cerebrovascular en términos de cognición, memoria y discapacidad posterior al accidente cerebrovascular. Los pacientes recibieron un placebo ( n = 40) o 500 mg/12 horas de citicolina ( n = 35) durante 12 semanas (por vía oral o intravenosa).…”

Experience with citicoline in patients with post-stroke cognitive impairment

“…Помимо этого цитиколин выступает в качестве донора холина, участвуя в синтезе ацетилхолина и тем самым оказывая значительное влияние на холинергическую нейротрансмиттерную систему, что приводит к значительному улучшению когнитивных функций [9,12]. Кокрейновский обзор эффективности цитиколина у пациентов с хронической цереброваскулярной патологией подтвердил улучшение памяти и внимания, уменьшение выраженности поведенческих нарушений и улучшение общего состояния больных на фоне терапии [13].…”