Citicolina: revisión farmacológica y clínica, actualización 2022

Ruiz, Julio J. Secades; Gareri, Pietro

doi:10.33588/rn.75s05.2022311

Cited by 38 publications

(5 citation statements)

References 463 publications

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“…Although acting at different cellular levels, both compounds represent to date some of the most promising neuroprotective supplements in ophthalmology with growing evidence demonstrating their efficacy against RGC degeneration (7)(8)(9)(10). In particular, niacin acts as a crucial regulator of mitochondrial metabolism and redox reactions (11) while citicoline stabilizes cell membranes through the synthesis of phospholipids (12) and the production of cardiolipin, thus inhibiting mitochondria-mediated apoptosis (13). In glaucoma models, diets supplemented with niacin have been demonstrated to protect RGCs from degeneration by supporting mitochondrial health and metabolism (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma

Melecchi,

Amato,

Dal Monte

et al. 2023

Front. Med.

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IntroductionMuch interest has been addressed to antioxidant dietary supplements that are known to lower the risk of developing glaucoma or delay its progression. Among them, niacin and citicoline protect retinal ganglion cells (RGCs) from degeneration by targeting mitochondria, though at different levels. A well-established mouse model of RGC degeneration induced by experimental intraocular pressure (IOP) elevation was used to investigate whether a novel combination of niacin/citicoline has better efficacy over each single component in preserving RGC health in response to IOP increase.MethodsOcular hypertension was induced by an intracameral injection of methylcellulose that clogs the trabecular meshwork. Electroretinography and immunohistochemistry were used to evaluate RGC function and density. Oxidative, inflammatory and apoptotic markers were evaluated by Western blot analysis.ResultsThe present results support an optimal efficacy of niacin with citicoline at their best dosage in preventing RGC loss. In fact, about 50% of RGCs were spared from death leading to improved electroretinographic responses to flash and pattern stimulation. Upregulated levels of oxidative stress and inflammatory markers were also consistently reduced by almost 50% after niacin with citicoline thus providing a significant strength to the validity of their combination.ConclusionNiacin combined with citicoline is highly effective in restoring RGC physiology but its therapeutic potential needs to be further explored. In fact, the translation of the present compound to humans is limited by several factors including the mouse modeling, the higher doses of the supplements that are necessary to demonstrate their efficacy over a short follow up period and the scarce knowledge of their transport to the bloodstream and to the eventual target tissues in the eye.

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Section: Introductionmentioning

confidence: 99%

Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma

Melecchi,

Amato,

Dal Monte

et al. 2023

Front. Med.

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“…барьера и уменьшению отека мозга, уменьшению размера ишемических очагов, ингибирует апоптоз нейронов [44]. Применение цитиколина уменьшало гибель и усиливало репарацию центральных нейронов и периферических нервов, предотвращая возникновение невропатической боли [44,45], усиливало раннюю увеличивало количество олигодендроцитов. Испытания влияния цитиколина предлагают провести у пациентов с рассеянным склерозом [46].…”

Section: Original Articleunclassified

“…Испытания влияния цитиколина предлагают провести у пациентов с рассеянным склерозом [46]. Его успешное использование отмечают при лечении лицевого неврита, эпилепсии, головокружения, тяжелого депрессивного расстройства, шизофрении [44]. Цитиколин улучшает зрительные функции у пациентов с глаукомой и с амблиопией [47].…”

Section: Original Articleunclassified

Changes in the electrical and viscoelastic parameters of erythrocytes in patients with manifestations of metabolic syndrome, COVID-19 convalescents, when exposed to citicoline in an in vitro experiment

Kruchinina,

Gromov,

Kruchinina

et al. 2024

Consilium Medicum

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Aim. To study changes in the electrical and viscoelastic parameters of erythrocytes using the method of dielectrophoresis in patients with manifestations of the metabolic syndrome who underwent COVID-19, when exposed to the drug citicoline in an in vitro experiment to reduce the severity of microcirculatory disorders. Materials and methods. 31 men were examined with manifestations of metabolic syndrome (50.6±9.9 years), COVID-19 convalescences, within 8 to 12 months after the disease, the diagnosis was confirmed by PCR, ELISA. The electrical and viscoelastic parameters of erythrocytes were studied by dielectrophoresis twice: the initial levels of indicators were determined and after 30 minutes of exposure with after 30 minutes of exposure to a solution of the drug Ronocyte (oral solution with the active substance citicoline sodium – 104.50 mg., which is equivalent to 100.00 mg citicoline at a concentration of 0.01 µl per 0.3 µl of red blood cell suspension in 0.3M sucrose solution (pH 7.36). Results. Exposure of erythrocyte suspension of patients with Ronocyte solution led to change in the levels of electrical, viscoelastic parameters: an increase in the average cell diameter (p=0.0003), the proportion of discocytes (p=0.0004), the amplitude of cell deformation at high frequencies of the electric field (p=0.000002), cell capacity (p=0.000007), the velocity of erythrocytes to the electrodes (p=0.003), dipole moment (p=0.002), polarizability at 106 and 0.5×106 Hz (p=0.000019 and p=0.0015, respectively), relative polarizability (p0.05) and, conversely, to reduce summarized rigidity (p=0.000003), viscosity (p=0.000002), electrical conductivity (p0.000001), aggregation indices (p=0.00003), destruction at frequencies of 106 Hz (p=0.003), 0.5x106 Hz (p=0.00002), 0.1×106 Hz (p0.00001), polarizability at low frequencies of the electric field (p=0.02). Under the influence of the drug, the equilibrium frequency of erythrocytes shifted to the low-frequency range compared to the initial values (p0.0000001). The revealed changes indicate an increase in the surface charge of erythrocytes, their ability to deform, and cell resistance under the action of citicoline. Conclusion. For the first time, the effect of the drug with the active substance citicoline, improving the rheological properties of erythrocytes, was discovered. Preparations with the active substance - citicoline should be considered promising for conducting a full-fledged clinical study to study the reduction of circulatory disorders at the microcirculatory level in patients with manifestations of metabolic syndrome who have undergone COVID-19 coronavirus infection.

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“…Perbedaan nebulizer dengan inhaler. [19][20][21] Citicoline dikenal dengan efek neuroprotektifnya yang bekerja pada regulasi homeostasis dan proses penuaan neuron, meningkatkan kadar neurotransmiter sinaps seperti dopamine dan norepinephrine yang melindungi neuron dari hipoksia, serta acetylcholine, mempreservasi cardiolipin dan sphingomyelin, proteksi dari eksotoksisitas glutamat, dan mempertahankan fungsi mitokondria. 21 Citicoline juga berperan menghambat inflamasi yang disebabkan oleh iskemia dengan menginhibisi fosfolipase A2.…”

Section: Metodeunclassified

“…Efek anti-apoptotiknya diketahui berefek positif terhadap glaukoma dan ambliopia. [19][20][21] Glaukoma merupakan penyakit degeneratif yang melibatkan nervus optikus dan sel ganglion retina, berakibat pada gangguan lapang pandang yang dapat berlanjut kebutaan. Studi menunjukkan degenerasi neuron tidak hanya terjadi pada kedua situs tersebut, melainkan juga sepanjang jaras visual dan otak.…”

Section: Metodeunclassified

Efektivitas Tetes Mata Citicoline terhadap Perbaikan Lapang Pandang dan Ketebalan Lapisan Serabut Saraf Retina pada Glaukoma Primer Sudut Terbuka

Dewi,

Soetedjo

2024

Cermin Dunia Kedokteran

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Primary open-angle glaucoma (POAG) is the second leading cause of irreversible blindness worldwide with increasing prevalence. Oral citicoline has been shown to have a role in glaucoma; however, studies regarding citicoline eye drops for glaucoma are still limited. This is a critical appraisal of the literature on the effectiveness of citicoline in improving the mean deviation (MD) of the visual field and thickness of the retinal nerve fiber layer (RNFL) in POAG. A literature search was done on 4 databases: PubMed, Cochrane, Embase, and Scopus. From the 165 studies initially identified, 3 studies were qualified for critical review. Rossetti demonstrated significant MD (p=0.02) and RNFL (p=0.04) differences after 3 years of citicoline eye drops compared to placebo. Mirachtsis showed that after citicoline administration for 3 months there was a significant difference in RNFL (p=0.029), but no significant improvement in MD (p>0.05). Parisi showed an improvement in MD after 4 months (+0.56 dB) and 6 months (+0.18 dB) of citicoline administration. Citicoline eye drops have the potential to inhibit glaucoma progression by inhibiting RNFL loss, but further research is needed on visual field improvement.

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Citicolina: revisión farmacológica y clínica, actualización 2022

Cited by 38 publications

References 463 publications

Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma

Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma

Changes in the electrical and viscoelastic parameters of erythrocytes in patients with manifestations of metabolic syndrome, COVID-19 convalescents, when exposed to citicoline in an in vitro experiment

Efektivitas Tetes Mata Citicoline terhadap Perbaikan Lapang Pandang dan Ketebalan Lapisan Serabut Saraf Retina pada Glaukoma Primer Sudut Terbuka

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