Risks of interleukin‐1 genetic polymorphisms and Helicobacter pylori infection in the development of gastric cancer

Abstract

SUMMARYBackground: The host genetic factors that determine the clinical outcomes of Helicobacter pylori-infected individuals remain unclear. Aim: To elucidate the risks of host interleukin-1 (IL-1) genetic polymorphisms and H. pylori infection in the development of gastric cancer. Methods: In a case-control study of 164 controls and 142 patients with gastric cancer, the IL-1B-511 biallelic polymorphisms and the IL-1RN penta-allelic variable number of tandem repeats were genotyped. Results: The carriage of IL-1RN*2, male gender, old age and H. pylori infection independently increased the risk

Interleukin-1 and TNF-α polymorphisms and Helicobacter pylori in a Brazilian Amazon population

“…El-Omar et al [7] have described an association between IL-1RN*2 and hypochloridria, and both gastric ulcer and stomach cancer reduce the synthesis of chloridic acid. Other studies have also described the association between the IL-1RN*2 polymorphisms and stomach cancer [23,24,33] . In Brazil, Rocha et al [34] obtained similar results in relation to the association of allele IL-RN*2 and an increased risk of developing stomach cancer, as well as the absence of an association between the IL-1β-31, TNF-α-308 polymorphisms and the risk of developing stomach cancer.…”

“…This finding is important for our region, which has a high incidence of stomach cancer, high prevalence of infection by CagA+ The confidence interval was not calculated, since, n1p1q1 < 5 or n2p2q2 < 5. [23,29,33] . In conclusion, our results suggest that bacterial virulence and genetic factors in the host act synergistically in the development of gastric ulcers and adenocarcinoma.…”

IL1RN polymorphic gene and cagA‐positive status independently increase the risk of noncardia gastric carcinoma

“…8 In fact, recently IL1B and IL1RN (interleukin-1 receptor antagonist) proinflammatory genotypes have been associated with an increased risk for hypochlorhydria, severe gastric lesions and the development of gastric carcinoma in both Caucasian and Asian populations. [9][10][11][12][13][14][15] Carriers of the polymorphic allele with a C instead of a T at position À31 of a regulatory region of the IL1B gene are thought to overexpress gastric IL-1b in response to H. pylori infection that amplifies the inflammation and increases gastric lesion. Furthermore, IL-1b is a powerful gastric acid inhibitor and increased gastric levels of IL-1b may cause hypochlorhydria.…”

The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

“…Многими учеными было установлено, что полимор-физм генов ИЛ-1В и ИЛ-1RN обусловливает воспаление и атрофию слизистой оболочки желудка, способствует канцерогенезу [40][41][42][43][44][45][46][47]. Так, при обследовании родствен-ников больных раком желудка было выявлено, что с нали-чием полиморфных вариантов ИЛ-1В -511/-31, ИЛ-1RN 2/2 значительно возрастает риск гипохлоргидрии и желу-дочной атрофии в присутствии H. pylori.…”

“…Ассоциация между полиморфизмом генов цитокинов ИЛ-1 и раком желудка, предраковыми состояниями была независимо подтверждена многими исследователями в странах всех континентов мира [19,22,[40][41][42][43][44][45][46][47]. В то же время в ряде работ статистически значимой взаимосвязи между полиморфизмом генов цитокинов ИЛ-1 и раком желудка обнаружено не было [48,49].…”