The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

Матвеева, Л. В.; Мосина, Л. М.

doi:10.15690/vramn.v67i11.473

Cited by 5 publications

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“…Превалирование сывороточного уровня МСР-1 у обследованных больных на фоне активного воспалительного процесса в желудке над значениями здоровых лиц подтверждает его функциональную активность как провоспалительного цитокина [1,5,6,8,9].…”

Section: Discussionunclassified

Changes Monocyte Chemoattractants Protein-1 in Helicobacter Pyloriassociated Gastroduodenal Diseases

Матвеева

Капкаева

Чудайкин

et al. 2018

Russian Journal of Infection and Immunity

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Chemoattractants monocyte protein-1 (MCP-1) is a low molecular weight cytokine, secreted by many cells of the body. The synthesis of MCP-1 can induce the lipopolysaccharides of bacteria, a range of cytokines. It is believed that MCP-1 regulates the migration and infiltration of tissue by monocytes, T-lymphocytes memory, natural killer cells, is involved in differentiation of naive T-helper cells. There is evidence oncogenic and antitumor activity of MCP-1 at different stages of tumor progression. The aim of this work was the determination and comparison of serum level of MCP-1 by infection with Helicobacter (H.) pylori in precancerous conditions and gastric cancer.Material and methods.Surveyed with the informed consent 204 patients with precancerous diseases of the stomach, 40 patients with gastric cancer and 40 healthy volunteers. Patients at esophagogastroduodenoscopy conducted the fence of material for target biopsy for histological and microbiological studies. Blood on the immunoassay climbed in the morning on an empty stomach from the cubital vein in a volume of 5 ml in a vial without preserving agent, the serum was separated by centrifugation for 10 minutes. By ELISA in the serum of patients determined the level of MCP-1, titer of total antibodies to the cytotoxin-associated protein of H. pylori. The obtained data statistically processed.Results. The amount of MCP-1 in serum of the patients significantly exceeded the data of healthy individuals in all groups of comparison. Values of MCP-1 during exacerbation of gastric ulcer was higher than patients with exacerbation of chronic not atrophic and focal atrophic gastritis. The concentration of MCP-1 > 280 pg/ml was detected in 17.6% of patients with pre-cancerous conditions of the stomach. When ulceration process there was a strong direct correlation of the severity of its course and the number of MCP-1 in serum. Serum level of MCP-1 in 5.0% of patients with gastric cancer was at the upper limit of normal values, and 77.5% of patients exceeded it. Indicator in gastric cancer significantly prevailed over the values in precancerous conditions, was correlated with the tumor stage. The level of MCP-1 in serum of the examined healthy volunteers, patients with exacerbation of chronic gastritis, gastric ulcer disease, polyposis, gastric cancer was correlated with the titers of total antibodies to the cytotoxin-associated protein of H. pylori.Conclusion. Determination of serum level of MCP-1 in precancerous conditions and gastric cancer is diagnostically valuable. Comparison of indicator values with the titers of total antibodies to the cytotoxin- associated protein of H. pylori prognostically significant, as it allows to assess the intensity of the induction signal to production of a cytokine.

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Section: Discussionunclassified

Changes Monocyte Chemoattractants Protein-1 in Helicobacter Pyloriassociated Gastroduodenal Diseases

Матвеева

Капкаева

Чудайкин

et al. 2018

Russian Journal of Infection and Immunity

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Soluble IL-1 decoy receptor is associated with gastric adenocarcinoma

Çakir¹,

Kilic²,

Coşkun³

et al. 2017

Turkish Journal of Biochemistry

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Background:In recent years, studies on gastric cancer include changes in cancer associated immune system activation and the levels of immune system markers. It has been demonstrated that TNF-α (tumor necrosis factor-alpha) and IL-6 (interleukin-6) play a role in inflammatory associated carcinogenesis.Objective:Our aim was to investigate serum soluble IL-1 decoy receptor (sIL- 1RII), TNF-α and IL-6 levels in gastric adenocarcinoma patients.Materials and methods:Male gastric adenocarcinoma patients and dyspeptic participants, in total 55 cases were included. Serum sIL-1RII, TNF-α and IL-6 concentrations were measured.Results:The median sIL-1RII levels of the patients were statistically significantly lower than the median of the control group (3111 ng/mL; 3601 ng/mL, respectively) (p=0.003). But the median TNF-α and IL-6 levels (58.17 ng/mL; 10.22 ng/mL, respectively) were both numerically higher than those of control group levels (16.62 ng/mL; 5.74 ng/mL, respectively). Also, patients’ median TNF-α levels were found statistically significantly higher (p=0.034).Conclusion:This study showed the increase of TNF-α, IL-6 levels and for the first time the decrease of sIL-1RII in gastric cancer patients. We propose that negative regulation of gastric cancer using sIL-1RII could be a new anti-cancer strategy.General significance:Our study provides target pathways for further studies in the pathophysiology of gastric cancer.

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Effect of epidural blockade on immune parameters in the perioperative period: randomized controlled study

Avetisian

Ezugbaia

Корячкин

et al. 2023

Regional Anesthesia and Acute Pain Management

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BACKGROUND: The potential benefits of anaesthesia techniques in the parameters of cellular immunity and prevention of metastasis in various types of cancer are attracting increasing attention. OBJECTIVE: Our aim was to estimate the influence of the epidural blockade as a component of the anesthesia support on the immunity indexes in the patients operated for gastric cancer. MATERIALS AND METHODS: 89 patients operated on for gastric cancer, divided into two groups were investigated: in the 1st group (n=27) there was general anesthesia (GA) in combination with extended epidural blockade; in the 2nd group (n=24) GA with postoperative intravenous administration of analgesics. T-cell counts (CD3+, CD4+ CD8+, CD4+/CD8+) and cytokines (IL-4, IL-6, IL-10, INF-y and TNF-a) were determined. RESULTS: The CD3+ T-cell levels in both groups were significantly (р 0.05) reduced immediately after surgery. On the 2nd and 3rd day the decrease in CD3+ T-cells was more pronounced (р 0.05) in the 2nd group compared to the 1st group. The content of CD4+ T-cells decreased by the 1st day of the postoperative period (р 0,05) but then gradually increased, the CD4+ level in the 1st group was significantly (р 0.05) higher than in the 2nd group. The changes of CD8+ content between the studied groups were not statistically significant. The immunoregulatory index in both groups decreased by1st day (р 0.05). On the 9th day the index in the 1st group returned to the basic values, while in the 2nd group it remained significantly lower. On the 1st and 3rd day, the levels of IL-4 and IL-6 significantly (р 0.05) increased, while in the 2nd group the levels were higher than in the 1st group (р 0.05). On the 9th day IL-4 and IL-6 indices returned to their initial values. The changes of IL-10 level had a similar pattern, while in the 1st group the rate was significantly higher (р 0.05). At all stages of investigation, the level of IFN- was significantly (р 0.05) higher in the 2nd group, the level of TNF- was higher in the 1st group (р 0.05). CONCLUSION: The use of postoperative epidural analgesia during gastric resection for malignant neoplasm is associated with a less suppressive effect on the content of subpopulations of T-lymphocytes and cytokines in comparison with intravenous administration of analgesics and may contribute to the activation of antitumor immune response. Prospective long-term studies are needed to evaluate physician epidural analgesia for oncological outcomes after surgery for gastric cancer.

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The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

Cited by 5 publications

References 31 publications

Changes Monocyte Chemoattractants Protein-1 in Helicobacter Pyloriassociated Gastroduodenal Diseases

Changes Monocyte Chemoattractants Protein-1 in Helicobacter Pyloriassociated Gastroduodenal Diseases

Soluble IL-1 decoy receptor is associated with gastric adenocarcinoma

Effect of epidural blockade on immune parameters in the perioperative period: randomized controlled study

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